Final published version
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
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TY - CHAP
T1 - Airborne Magnetite- And Iron-Rich Pollution Nanoparticles
T2 - Potential Neurotoxicants and Environmental Risk Factors for Neurodegenerative Disease, including Alzheimer's Disease
AU - Maher, Barbara A.
N1 - Publisher Copyright: © 2021 The authors and IOS Press. All rights reserved.
PY - 2021/5/31
Y1 - 2021/5/31
N2 - Fewer than 5% of Alzheimer's disease (AD) cases are demonstrably directly inherited, indicating that environmental factors may be important in initiating and/or promoting the disease. Excess iron is toxic to cells; iron overload in the AD brain may aggressively accelerate AD. Magnetite nanoparticles, capable of catalyzing formation of reactive oxygen species, occur in AD plaques and tangles; they are thought to form in situ, from pathological iron dysfunction. A recent study has identified in frontal cortex samples the abundant presence of magnetite nanoparticles consistent with high-temperature formation; identifying therefore their external, not internal source. These magnetite particles range from 1/410 to 150 nm in size, and are often associated with other, non-endogenous metals (including platinum, cadmium, cerium). Some display rounded crystal morphologies and fused surface textures, reflecting cooling and crystallization from an initially heated, iron-bearing source material. Precisely-matching magnetite € nanospheres' occur abundantly in roadside air pollution, arising from vehicle combustion and, especially, frictional brake-wear. Airborne magnetite pollution particles
AB - Fewer than 5% of Alzheimer's disease (AD) cases are demonstrably directly inherited, indicating that environmental factors may be important in initiating and/or promoting the disease. Excess iron is toxic to cells; iron overload in the AD brain may aggressively accelerate AD. Magnetite nanoparticles, capable of catalyzing formation of reactive oxygen species, occur in AD plaques and tangles; they are thought to form in situ, from pathological iron dysfunction. A recent study has identified in frontal cortex samples the abundant presence of magnetite nanoparticles consistent with high-temperature formation; identifying therefore their external, not internal source. These magnetite particles range from 1/410 to 150 nm in size, and are often associated with other, non-endogenous metals (including platinum, cadmium, cerium). Some display rounded crystal morphologies and fused surface textures, reflecting cooling and crystallization from an initially heated, iron-bearing source material. Precisely-matching magnetite € nanospheres' occur abundantly in roadside air pollution, arising from vehicle combustion and, especially, frictional brake-wear. Airborne magnetite pollution particles
KW - Air pollution
KW - Alzheimer's disease
KW - inhalation exposure
KW - iron overload
KW - magnetite nanoparticles
KW - metal nanoparticles
U2 - 10.3233/AIAD210006
DO - 10.3233/AIAD210006
M3 - Chapter
AN - SCOPUS:85105067312
SN - 9781643681580
T3 - Advances in Alzheimer's Disease
SP - 69
EP - 83
BT - Alzheimer's Disease and Air Pollution
A2 - Calderon-Garciduenas, Lilian
PB - IOS Press BV
ER -