Home > Research > Publications & Outputs > Alginate/Chitosan Particle-Based Drug Delivery ...

Electronic data


Text available via DOI:

View graph of relations

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Marcus Hill
  • Matthew Twigg
  • Emer Sheridan
  • John Hardy
  • Joseph Elborn
  • Clifford Taggart
  • Christopher Scott
  • Marie Migaud
Article number379
<mark>Journal publication date</mark>2/08/2019
Issue number8
Number of pages12
Publication StatusPublished
<mark>Original language</mark>English


Cystic fibrosis (CF) is a complex, potentially life-threatening disease that is most effectively treated through the administration of antibiotics (e.g., colistimethate sodium). Chronic infection with Pseudomonas aeruginosa is one of the most significant events in the pathogenesis of cystic fibrosis, and tobramycin is the treatment of choice for those patients with chronic P. aeruginosa infection who are deteriorating despite regular administration of colistimethate sodium. Effective treatment can be challenging due to the accumulation of thickened mucus in the pulmonary environment, and here we describe the results of our investigation into the development of alginate/chitosan particles prepared via precipitation for such environments. Tobramycin loading and release from the alginate/chitosan particles was investigated, with evidence of both uptake and release of sufficient tobramycin to inhibit P. aeruginosa in vitro. Functionalisation of the alginate/chitosan particles with secretory leukocyte protease inhibitor (SLPI) was shown to help inhibit the inflammatory response associated with lung infections (via inhibition of neutrophil elastase activity) and enhance their interaction with cystic fibrosis mucus (assayed via reduction of the depth of particle penetration into the mucus) in vitro, which have prospects to enhance their efficacy in vivo.