Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease. / Stamatelopoulos, Kimon; Sibbing, Dirk; Rallidis, Loukianos S et al.
In: Journal of the American College of Cardiology, Vol. 65, No. 9, 10.03.2015, p. 904-916.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Stamatelopoulos, K, Sibbing, D, Rallidis, LS, Georgiopoulos, G, Stakos, D, Braun, S, Gatsiou, A, Sopova, K, Kotakos, C, Varounis, C, Tellis, CC, Kastritis, E, Alevizaki, M, Tselepis, AD, Alexopoulos, P, Laske, C, Keller, T, Kastrati, A, Dimmeler, S, Zeiher, AM & Stellos, K 2015, 'Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease', Journal of the American College of Cardiology, vol. 65, no. 9, pp. 904-916. https://doi.org/10.1016/j.jacc.2014.12.035

APA

Stamatelopoulos, K., Sibbing, D., Rallidis, L. S., Georgiopoulos, G., Stakos, D., Braun, S., Gatsiou, A., Sopova, K., Kotakos, C., Varounis, C., Tellis, C. C., Kastritis, E., Alevizaki, M., Tselepis, A. D., Alexopoulos, P., Laske, C., Keller, T., Kastrati, A., Dimmeler, S., ... Stellos, K. (2015). Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease. Journal of the American College of Cardiology, 65(9), 904-916. https://doi.org/10.1016/j.jacc.2014.12.035

Vancouver

Stamatelopoulos K, Sibbing D, Rallidis LS, Georgiopoulos G, Stakos D, Braun S et al. Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease. Journal of the American College of Cardiology. 2015 Mar 10;65(9):904-916. doi: 10.1016/j.jacc.2014.12.035

Author

Stamatelopoulos, Kimon ; Sibbing, Dirk ; Rallidis, Loukianos S et al. / Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease. In: Journal of the American College of Cardiology. 2015 ; Vol. 65, No. 9. pp. 904-916.

Bibtex

@article{91e47bd397fb4d62a64356d16697885a,

title = "Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease",

abstract = "BACKGROUND: The amyloid beta peptide is the major protein constituent of neuritic plaques in Alzheimer disease and appears to play a central role in vascular inflammation pathophysiology.OBJECTIVES: This study sought to determine the clinical value of amyloid-beta 1-40 (Abeta40) measurement in predicting cardiovascular (CV) mortality in patients with coronary heart disease (CHD) and arterial stiffness progression in young healthy subjects.METHODS: Abeta40 was retrospectively measured in blood samples collected from 3 independent prospective cohorts and 2 case-control cohorts (total N = 1,464). Major adverse cardiac events (MACE) were assessed in the 2 prospective cohorts (n = 877) followed for a median of 4.4 years. To look at effects on subclinical disease, arterial stiffness was evaluated at baseline and after 5-year follow-up (n = 107) in young healthy subjects. The primary endpoint was the predictive value of Abeta40 for CV mortality and outcomes in patients with CHD.RESULTS: In Cox proportional hazards models adjusted for age, sex, estimated glomerular filtration rate, left ventricular ejection fraction, high-sensitivity C-reactive protein, and high-sensitivity troponin T, Abeta40 independently predicted CV death and MACE in patients with CHD (p < 0.05 for all). After multivariate adjustment, Abeta40 levels conferred a substantial enhancement of net reclassification index and integrated discrimination improvement of individuals at risk in the total combined CHD cohort over the best predictive model. Further cohort-based analysis revealed that Abeta40 levels were significantly and independently associated with arterial stiffness progression, incident subclinical atherosclerosis, and incident CHD.CONCLUSIONS: Measuring blood levels of Abeta40 identified patients at high risk for CV death.",

keywords = "Age Factors, Aged, Amyloid beta-Peptides/blood, Ankle Brachial Index, Biomarkers/blood, C-Reactive Protein/analysis, Carotid Intima-Media Thickness, Cause of Death, Coronary Disease/blood, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Male, Middle Aged, Myocardial Infarction/blood, Peptide Fragments/blood, Plaque, Atherosclerotic, Proportional Hazards Models, Retrospective Studies, Stroke Volume, Troponin T/blood, Vascular Stiffness",

author = "Kimon Stamatelopoulos and Dirk Sibbing and Rallidis, {Loukianos S} and Georgios Georgiopoulos and Dimitrios Stakos and Siegmund Braun and Aikaterini Gatsiou and Kateryna Sopova and Christos Kotakos and Christos Varounis and Tellis, {Constantinos C} and Efstathios Kastritis and Maria Alevizaki and Tselepis, {Alexandros D} and Panagiotis Alexopoulos and Christoph Laske and Till Keller and Adnan Kastrati and Stefanie Dimmeler and Zeiher, {Andreas M} and Konstantinos Stellos",

year = "2015",

month = mar,

day = "10",

doi = "10.1016/j.jacc.2014.12.035",

language = "English",

volume = "65",

pages = "904--916",

journal = "Journal of the American College of Cardiology",

issn = "1558-3597",

publisher = "Elsevier USA",

number = "9",

}

RIS

TY - JOUR

T1 - Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease

AU - Stamatelopoulos, Kimon

AU - Sibbing, Dirk

AU - Rallidis, Loukianos S

AU - Georgiopoulos, Georgios

AU - Stakos, Dimitrios

AU - Braun, Siegmund

AU - Gatsiou, Aikaterini

AU - Sopova, Kateryna

AU - Kotakos, Christos

AU - Varounis, Christos

AU - Tellis, Constantinos C

AU - Kastritis, Efstathios

AU - Alevizaki, Maria

AU - Tselepis, Alexandros D

AU - Alexopoulos, Panagiotis

AU - Laske, Christoph

AU - Keller, Till

AU - Kastrati, Adnan

AU - Dimmeler, Stefanie

AU - Zeiher, Andreas M

AU - Stellos, Konstantinos

PY - 2015/3/10

Y1 - 2015/3/10

N2 - BACKGROUND: The amyloid beta peptide is the major protein constituent of neuritic plaques in Alzheimer disease and appears to play a central role in vascular inflammation pathophysiology.OBJECTIVES: This study sought to determine the clinical value of amyloid-beta 1-40 (Abeta40) measurement in predicting cardiovascular (CV) mortality in patients with coronary heart disease (CHD) and arterial stiffness progression in young healthy subjects.METHODS: Abeta40 was retrospectively measured in blood samples collected from 3 independent prospective cohorts and 2 case-control cohorts (total N = 1,464). Major adverse cardiac events (MACE) were assessed in the 2 prospective cohorts (n = 877) followed for a median of 4.4 years. To look at effects on subclinical disease, arterial stiffness was evaluated at baseline and after 5-year follow-up (n = 107) in young healthy subjects. The primary endpoint was the predictive value of Abeta40 for CV mortality and outcomes in patients with CHD.RESULTS: In Cox proportional hazards models adjusted for age, sex, estimated glomerular filtration rate, left ventricular ejection fraction, high-sensitivity C-reactive protein, and high-sensitivity troponin T, Abeta40 independently predicted CV death and MACE in patients with CHD (p < 0.05 for all). After multivariate adjustment, Abeta40 levels conferred a substantial enhancement of net reclassification index and integrated discrimination improvement of individuals at risk in the total combined CHD cohort over the best predictive model. Further cohort-based analysis revealed that Abeta40 levels were significantly and independently associated with arterial stiffness progression, incident subclinical atherosclerosis, and incident CHD.CONCLUSIONS: Measuring blood levels of Abeta40 identified patients at high risk for CV death.

AB - BACKGROUND: The amyloid beta peptide is the major protein constituent of neuritic plaques in Alzheimer disease and appears to play a central role in vascular inflammation pathophysiology.OBJECTIVES: This study sought to determine the clinical value of amyloid-beta 1-40 (Abeta40) measurement in predicting cardiovascular (CV) mortality in patients with coronary heart disease (CHD) and arterial stiffness progression in young healthy subjects.METHODS: Abeta40 was retrospectively measured in blood samples collected from 3 independent prospective cohorts and 2 case-control cohorts (total N = 1,464). Major adverse cardiac events (MACE) were assessed in the 2 prospective cohorts (n = 877) followed for a median of 4.4 years. To look at effects on subclinical disease, arterial stiffness was evaluated at baseline and after 5-year follow-up (n = 107) in young healthy subjects. The primary endpoint was the predictive value of Abeta40 for CV mortality and outcomes in patients with CHD.RESULTS: In Cox proportional hazards models adjusted for age, sex, estimated glomerular filtration rate, left ventricular ejection fraction, high-sensitivity C-reactive protein, and high-sensitivity troponin T, Abeta40 independently predicted CV death and MACE in patients with CHD (p < 0.05 for all). After multivariate adjustment, Abeta40 levels conferred a substantial enhancement of net reclassification index and integrated discrimination improvement of individuals at risk in the total combined CHD cohort over the best predictive model. Further cohort-based analysis revealed that Abeta40 levels were significantly and independently associated with arterial stiffness progression, incident subclinical atherosclerosis, and incident CHD.CONCLUSIONS: Measuring blood levels of Abeta40 identified patients at high risk for CV death.

KW - Age Factors

KW - Aged

KW - Amyloid beta-Peptides/blood

KW - Ankle Brachial Index

KW - Biomarkers/blood

KW - C-Reactive Protein/analysis

KW - Carotid Intima-Media Thickness

KW - Cause of Death

KW - Coronary Disease/blood

KW - Female

KW - Follow-Up Studies

KW - Glomerular Filtration Rate

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/blood

KW - Peptide Fragments/blood

KW - Plaque, Atherosclerotic

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Stroke Volume

KW - Troponin T/blood

KW - Vascular Stiffness

U2 - 10.1016/j.jacc.2014.12.035

DO - 10.1016/j.jacc.2014.12.035

M3 - Journal article

C2 - 25744007

VL - 65

SP - 904

EP - 916

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 1558-3597

IS - 9

ER -

Research

Links

Text available via DOI:

Keywords