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An amide hydrogen bond templated [1]rotaxane displaying a peptide motif - demonstrating an expedient route to synthetic mimics of lasso peptides

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Published
<mark>Journal publication date</mark>21/07/2020
<mark>Journal</mark>Organic and Biomolecular Chemistry
Issue number27
Volume18
Number of pages7
Pages (from-to)5203-5209
Publication StatusPublished
Early online date24/06/20
<mark>Original language</mark>English

Abstract

The rapid synthesis of an amide hydrogen bond templated [1]rotaxane is reported - demonstrating a potential pathway to synthetic analogues of lasso peptides. The structures of the [1]rotaxane and its unthreaded isomer have been characterized by NMR spectroscopy and modelled using DFT calculations.