It is already well understood that unbinding materials and energy from their lithic reservoirs impacts upon Earth systems. But that is just the first stage of a cycle of ‘Anthropocene trouble’. This paper tracks the multiple ways in which subsequent Earth system change reacts back upon the social infrastructures of subsurface exploitation and the landscapes they produce. Shifting fire regimes, intensifying hydro- meteorological events and sea level rise impact upon the infrastructures of hydrocarbon extraction, hydroclimatic change impacts upon infrastructures and landscapes of mineral extraction, and both pyroclimatic and hydroclimatic change impact upon nuclear infrastructures and on landscapes already contaminated by radioactive materials. To make sense of these ‘negative synergies’ we draw upon social science diagnoses of late modern hazards as well Anthropocene science’s deepening collaboration between ‘hard rock’ geology and Earth system science.