Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - An electrokinetic bioreactor: using direct electric current for enhanced lactic acid fermentation and product recovery.
AU - Li, Hong
AU - Mustacchi, Roberta
AU - Knowles, Christopher J.
AU - Skibar, Wolfgang
AU - Sunderland, Garry
AU - Dalrymple, Ian
AU - Jackman, Simon A.
PY - 2004/1/12
Y1 - 2004/1/12
N2 - The microbiological production of organic acids by fermentation processes is growing in commercial importance. However, the removal of product and pH control are two main issues that limit the technical and commercial viability of such processes. A laboratory scale bioreactor combining conventional electrodialysis and bipolar membrane electrodialysis has been developed for in situ product removal and pH control in lactic acid fermentation. The electrokinetic process enabled removal of the biocatalytic product (lactic acid) directly from the bioreactor system, in a concentrated form, as well as enabling good pH control without generation of troublesome salts. Moreover, end-product inhibition of glucose catabolism was reduced, resulting in a greater generation of the end-product lactic acid. An automatic pH sensor and current application system was developed and successfully implemented for lactic acid fermentation in the electrokinetic bioreactor.
AB - The microbiological production of organic acids by fermentation processes is growing in commercial importance. However, the removal of product and pH control are two main issues that limit the technical and commercial viability of such processes. A laboratory scale bioreactor combining conventional electrodialysis and bipolar membrane electrodialysis has been developed for in situ product removal and pH control in lactic acid fermentation. The electrokinetic process enabled removal of the biocatalytic product (lactic acid) directly from the bioreactor system, in a concentrated form, as well as enabling good pH control without generation of troublesome salts. Moreover, end-product inhibition of glucose catabolism was reduced, resulting in a greater generation of the end-product lactic acid. An automatic pH sensor and current application system was developed and successfully implemented for lactic acid fermentation in the electrokinetic bioreactor.
U2 - 10.1016/j.tet.2003.10.110
DO - 10.1016/j.tet.2003.10.110
M3 - Journal article
VL - 60
SP - 655
EP - 661
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 3
ER -