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An Integrated District Mapping Strategy for Loiasis to Enable Safe Mass Treatment for Onchocerciasis in Gabon

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An Integrated District Mapping Strategy for Loiasis to Enable Safe Mass Treatment for Onchocerciasis in Gabon. / Ella, Sylvie Ntsame; Ogoussan, Kisito; Gass, Katherine et al.
In: The American Journal of Tropical Medicine and Hygiene, Vol. 106, No. 2, 15.11.2021, p. 732-739.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Ella, SN, Ogoussan, K, Gass, K, Hundley, L, Diggle, PJ, Johnson, O, Biamonte, M & Atsame, J 2021, 'An Integrated District Mapping Strategy for Loiasis to Enable Safe Mass Treatment for Onchocerciasis in Gabon', The American Journal of Tropical Medicine and Hygiene, vol. 106, no. 2, pp. 732-739. https://doi.org/10.4269/ajtmh.21-0799

APA

Ella, S. N., Ogoussan, K., Gass, K., Hundley, L., Diggle, P. J., Johnson, O., Biamonte, M., & Atsame, J. (2021). An Integrated District Mapping Strategy for Loiasis to Enable Safe Mass Treatment for Onchocerciasis in Gabon. The American Journal of Tropical Medicine and Hygiene, 106(2), 732-739. https://doi.org/10.4269/ajtmh.21-0799

Vancouver

Ella SN, Ogoussan K, Gass K, Hundley L, Diggle PJ, Johnson O et al. An Integrated District Mapping Strategy for Loiasis to Enable Safe Mass Treatment for Onchocerciasis in Gabon. The American Journal of Tropical Medicine and Hygiene. 2021 Nov 15;106(2):732-739. doi: 10.4269/ajtmh.21-0799

Author

Ella, Sylvie Ntsame ; Ogoussan, Kisito ; Gass, Katherine et al. / An Integrated District Mapping Strategy for Loiasis to Enable Safe Mass Treatment for Onchocerciasis in Gabon. In: The American Journal of Tropical Medicine and Hygiene. 2021 ; Vol. 106, No. 2. pp. 732-739.

Bibtex

@article{cae0186bef8749dd822972c0deb78f0f,
title = "An Integrated District Mapping Strategy for Loiasis to Enable Safe Mass Treatment for Onchocerciasis in Gabon",
abstract = "The lack of a WHO-recommended strategy for onchocerciasis treatment with ivermectin in hypo-endemic areas co-endemic with loiasis is an impediment to global onchocerciasis elimination. New loiasis diagnostics (LoaScope; Loa antibody rapid test) and risk prediction tools may enable safe mass treatment decisions in co-endemic areas. In 2017–2018, an integrated mapping strategy for onchocerciasis, lymphatic filariasis (LF), and loiasis, aimed at enabling safe ivermectin treatment decisions, was piloted in Gabon. Three ivermectin-na{\"i}ve departments suspected to be hypo-endemic were selected and up to 100 adults per village across 30 villages in each of the three departments underwent testing for indicators of onchocerciasis, LF, and loiasis. An additional 67 communities in five adjoining departments were tested for loiasis to extend the prevalence and intensity predictions and possibly expand the boundaries of areas deemed safe for ivermectin treatment. Integrated testing in the three departments revealed within-department heterogeneity for all the three diseases, highlighting the value of a mapping approach that relies on cluster-based sampling rather than sentinel sites. These results suggest that safe mass treatment of onchocerciasis may be possible at the subdepartment level, even in departments where loiasis is present. Beyond valuable epidemiologic data, the study generated insight into the performance of various diagnostics and the feasibility of an integrated mapping approach utilizing new diagnostic and modeling tools. Further research should explore how programs can combine these diagnostic and risk prediction tools into a feasible programmatic strategy to enable safe treatment decisions where loiasis and onchocerciasis are co-endemic.",
keywords = "Virology, Infectious Diseases, Parasitology",
author = "Ella, {Sylvie Ntsame} and Kisito Ogoussan and Katherine Gass and Lee Hundley and Diggle, {Peter J.} and Olatunji Johnson and Marco Biamonte and Julienne Atsame",
year = "2021",
month = nov,
day = "15",
doi = "10.4269/ajtmh.21-0799",
language = "English",
volume = "106",
pages = "732--739",
journal = "The American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "2",

}

RIS

TY - JOUR

T1 - An Integrated District Mapping Strategy for Loiasis to Enable Safe Mass Treatment for Onchocerciasis in Gabon

AU - Ella, Sylvie Ntsame

AU - Ogoussan, Kisito

AU - Gass, Katherine

AU - Hundley, Lee

AU - Diggle, Peter J.

AU - Johnson, Olatunji

AU - Biamonte, Marco

AU - Atsame, Julienne

PY - 2021/11/15

Y1 - 2021/11/15

N2 - The lack of a WHO-recommended strategy for onchocerciasis treatment with ivermectin in hypo-endemic areas co-endemic with loiasis is an impediment to global onchocerciasis elimination. New loiasis diagnostics (LoaScope; Loa antibody rapid test) and risk prediction tools may enable safe mass treatment decisions in co-endemic areas. In 2017–2018, an integrated mapping strategy for onchocerciasis, lymphatic filariasis (LF), and loiasis, aimed at enabling safe ivermectin treatment decisions, was piloted in Gabon. Three ivermectin-naïve departments suspected to be hypo-endemic were selected and up to 100 adults per village across 30 villages in each of the three departments underwent testing for indicators of onchocerciasis, LF, and loiasis. An additional 67 communities in five adjoining departments were tested for loiasis to extend the prevalence and intensity predictions and possibly expand the boundaries of areas deemed safe for ivermectin treatment. Integrated testing in the three departments revealed within-department heterogeneity for all the three diseases, highlighting the value of a mapping approach that relies on cluster-based sampling rather than sentinel sites. These results suggest that safe mass treatment of onchocerciasis may be possible at the subdepartment level, even in departments where loiasis is present. Beyond valuable epidemiologic data, the study generated insight into the performance of various diagnostics and the feasibility of an integrated mapping approach utilizing new diagnostic and modeling tools. Further research should explore how programs can combine these diagnostic and risk prediction tools into a feasible programmatic strategy to enable safe treatment decisions where loiasis and onchocerciasis are co-endemic.

AB - The lack of a WHO-recommended strategy for onchocerciasis treatment with ivermectin in hypo-endemic areas co-endemic with loiasis is an impediment to global onchocerciasis elimination. New loiasis diagnostics (LoaScope; Loa antibody rapid test) and risk prediction tools may enable safe mass treatment decisions in co-endemic areas. In 2017–2018, an integrated mapping strategy for onchocerciasis, lymphatic filariasis (LF), and loiasis, aimed at enabling safe ivermectin treatment decisions, was piloted in Gabon. Three ivermectin-naïve departments suspected to be hypo-endemic were selected and up to 100 adults per village across 30 villages in each of the three departments underwent testing for indicators of onchocerciasis, LF, and loiasis. An additional 67 communities in five adjoining departments were tested for loiasis to extend the prevalence and intensity predictions and possibly expand the boundaries of areas deemed safe for ivermectin treatment. Integrated testing in the three departments revealed within-department heterogeneity for all the three diseases, highlighting the value of a mapping approach that relies on cluster-based sampling rather than sentinel sites. These results suggest that safe mass treatment of onchocerciasis may be possible at the subdepartment level, even in departments where loiasis is present. Beyond valuable epidemiologic data, the study generated insight into the performance of various diagnostics and the feasibility of an integrated mapping approach utilizing new diagnostic and modeling tools. Further research should explore how programs can combine these diagnostic and risk prediction tools into a feasible programmatic strategy to enable safe treatment decisions where loiasis and onchocerciasis are co-endemic.

KW - Virology

KW - Infectious Diseases

KW - Parasitology

U2 - 10.4269/ajtmh.21-0799

DO - 10.4269/ajtmh.21-0799

M3 - Journal article

VL - 106

SP - 732

EP - 739

JO - The American Journal of Tropical Medicine and Hygiene

JF - The American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 2

ER -