Angiotensin-converting enzyme as a target for the development of novel insect growth regulators.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Angiotensin-converting enzyme as a target for the development of novel insect growth regulators. / Isaac, R. Elwyn; Lamango, Nazarius S.; Ekbote, Uma et al.
In: Peptides, Vol. 28, No. 1, 01.2007, p. 153-162.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Isaac, RE, Lamango, NS, Ekbote, U, Taylor, CA , Hurst, D, Weaver, RJ, Carhan, A, Burnham, S & Shirras, AD 2007, 'Angiotensin-converting enzyme as a target for the development of novel insect growth regulators.', Peptides, vol. 28, no. 1, pp. 153-162. https://doi.org/10.1016/j.peptides.2006.08.029

APA

Isaac, R. E., Lamango, N. S., Ekbote, U., Taylor, C. A., Hurst, D., Weaver, R. J., Carhan, A., Burnham, S., & Shirras, A. D. (2007). Angiotensin-converting enzyme as a target for the development of novel insect growth regulators. Peptides, 28(1), 153-162. https://doi.org/10.1016/j.peptides.2006.08.029

Vancouver

Isaac RE, Lamango NS, Ekbote U, Taylor CA , Hurst D, Weaver RJ et al. Angiotensin-converting enzyme as a target for the development of novel insect growth regulators. Peptides. 2007 Jan;28(1):153-162. doi: 10.1016/j.peptides.2006.08.029

Author

Isaac, R. Elwyn ; Lamango, Nazarius S. ; Ekbote, Uma et al. / Angiotensin-converting enzyme as a target for the development of novel insect growth regulators. In: Peptides. 2007 ; Vol. 28, No. 1. pp. 153-162.

Bibtex

@article{38e4808354aa46208b69efdfc7d96f24,

title = "Angiotensin-converting enzyme as a target for the development of novel insect growth regulators.",

abstract = "Insect angiotensin converting enzyme (ACE) is a zinc metallopeptidase capable of inactivating a variety of small to medium size peptide hormones by cleavage of C-terminal dipeptides and dipeptideamides. High levels of ACE activity are found in the hemolymph and in reproductive tissues of insects, where the enzyme is considered to have an important role in the metabolism of bioactive peptides. Therefore, inhibiting ACE activity is expected to interfere with the peptidergic endocrine system and to have detrimental effects on growth, development and reproduction. We will review the studies showing that ACE inhibitors do indeed disrupt growth and reproduction in various insect species. We will also present some new genetic and pharmacological data that strengthens our conclusion that ACE should be considered as a potential target for the development of new insect growth regulators.",

keywords = "Insect control, Angiotensin-converting enzyme, Reproduction, Peptidase, ANCE, ACE inhibitors",

author = "Isaac, {R. Elwyn} and Lamango, {Nazarius S.} and Uma Ekbote and Taylor, {C. A.} and Debra Hurst and Weaver, {Robert J.} and Ahmet Carhan and Susan Burnham and Shirras, {Alan D.}",

year = "2007",

month = jan,

doi = "10.1016/j.peptides.2006.08.029",

language = "English",

volume = "28",

pages = "153--162",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "1",

}

RIS

TY - JOUR

T1 - Angiotensin-converting enzyme as a target for the development of novel insect growth regulators.

AU - Isaac, R. Elwyn

AU - Lamango, Nazarius S.

AU - Ekbote, Uma

AU - Taylor, C. A.

AU - Hurst, Debra

AU - Weaver, Robert J.

AU - Carhan, Ahmet

AU - Burnham, Susan

AU - Shirras, Alan D.

PY - 2007/1

Y1 - 2007/1

N2 - Insect angiotensin converting enzyme (ACE) is a zinc metallopeptidase capable of inactivating a variety of small to medium size peptide hormones by cleavage of C-terminal dipeptides and dipeptideamides. High levels of ACE activity are found in the hemolymph and in reproductive tissues of insects, where the enzyme is considered to have an important role in the metabolism of bioactive peptides. Therefore, inhibiting ACE activity is expected to interfere with the peptidergic endocrine system and to have detrimental effects on growth, development and reproduction. We will review the studies showing that ACE inhibitors do indeed disrupt growth and reproduction in various insect species. We will also present some new genetic and pharmacological data that strengthens our conclusion that ACE should be considered as a potential target for the development of new insect growth regulators.

AB - Insect angiotensin converting enzyme (ACE) is a zinc metallopeptidase capable of inactivating a variety of small to medium size peptide hormones by cleavage of C-terminal dipeptides and dipeptideamides. High levels of ACE activity are found in the hemolymph and in reproductive tissues of insects, where the enzyme is considered to have an important role in the metabolism of bioactive peptides. Therefore, inhibiting ACE activity is expected to interfere with the peptidergic endocrine system and to have detrimental effects on growth, development and reproduction. We will review the studies showing that ACE inhibitors do indeed disrupt growth and reproduction in various insect species. We will also present some new genetic and pharmacological data that strengthens our conclusion that ACE should be considered as a potential target for the development of new insect growth regulators.

KW - Insect control

KW - Angiotensin-converting enzyme

KW - Reproduction

KW - Peptidase

KW - ANCE

KW - ACE inhibitors

U2 - 10.1016/j.peptides.2006.08.029

DO - 10.1016/j.peptides.2006.08.029

M3 - Journal article

VL - 28

SP - 153

EP - 162

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 1

ER -

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