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Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm.

Research output: Contribution to Journal/MagazineJournal article

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Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm. / Pritchard, D. I.; Quinnell, R. J.; McKean, Paul G. et al.
In: Transactions of The Royal Society of Tropical Medicine and Hygiene, Vol. 85, No. 4, 07.1991, p. 511-514.

Research output: Contribution to Journal/MagazineJournal article

Harvard

Pritchard, DI, Quinnell, RJ, McKean, PG, Walsh, L, Leggett, KV, Slater, AF, Raiko, A, Dale, DD & Keymer, AE 1991, 'Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm.', Transactions of The Royal Society of Tropical Medicine and Hygiene, vol. 85, no. 4, pp. 511-514. https://doi.org/10.1016/0035-9203(91)90239-U

APA

Pritchard, D. I., Quinnell, R. J., McKean, P. G., Walsh, L., Leggett, K. V., Slater, A. F., Raiko, A., Dale, D. D., & Keymer, A. E. (1991). Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm. Transactions of The Royal Society of Tropical Medicine and Hygiene, 85(4), 511-514. https://doi.org/10.1016/0035-9203(91)90239-U

Vancouver

Pritchard DI, Quinnell RJ, McKean PG, Walsh L, Leggett KV, Slater AF et al. Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm. Transactions of The Royal Society of Tropical Medicine and Hygiene. 1991 Jul;85(4):511-514. doi: 10.1016/0035-9203(91)90239-U

Author

Pritchard, D. I. ; Quinnell, R. J. ; McKean, Paul G. et al. / Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm. In: Transactions of The Royal Society of Tropical Medicine and Hygiene. 1991 ; Vol. 85, No. 4. pp. 511-514.

Bibtex

@article{6f73116aa5b84516a6e58ab387077aba,
title = "Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm.",
abstract = "Sero-epidemiological data are presented in which antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides has been investigated in a community in Papua New Guinea infected predominantly with N. americanus. It is our contention that the antigenic cross-reactivity which undoubtedly exists between these species accounted for (i) a peak in antibody levels against N. americanus in 10-13 years old children (driven by infection with A. lumbricoides), and (ii) the maintenance of apparent antibody levels against A. lumbricoides in older age groups (driven by infection with N. americanus in the absence of overt infection with A. lumbricoides). Cross-reactivity was analysed further, and apparently N. americanus-specific epitopes identified, by immunoblotting. These observations could have considerable bearing on the interpretation of data from sero-epidemiological studies which failed to take account of concurrent infection with these parasites.",
author = "Pritchard, {D. I.} and Quinnell, {R. J.} and McKean, {Paul G.} and L. Walsh and Leggett, {K. V.} and Slater, {A. F.} and A. Raiko and Dale, {D. D.} and Keymer, {A. E.}",
year = "1991",
month = jul,
doi = "10.1016/0035-9203(91)90239-U",
language = "English",
volume = "85",
pages = "511--514",
journal = "Transactions of The Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
publisher = "Oxford University Press Inc",
number = "4",

}

RIS

TY - JOUR

T1 - Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm.

AU - Pritchard, D. I.

AU - Quinnell, R. J.

AU - McKean, Paul G.

AU - Walsh, L.

AU - Leggett, K. V.

AU - Slater, A. F.

AU - Raiko, A.

AU - Dale, D. D.

AU - Keymer, A. E.

PY - 1991/7

Y1 - 1991/7

N2 - Sero-epidemiological data are presented in which antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides has been investigated in a community in Papua New Guinea infected predominantly with N. americanus. It is our contention that the antigenic cross-reactivity which undoubtedly exists between these species accounted for (i) a peak in antibody levels against N. americanus in 10-13 years old children (driven by infection with A. lumbricoides), and (ii) the maintenance of apparent antibody levels against A. lumbricoides in older age groups (driven by infection with N. americanus in the absence of overt infection with A. lumbricoides). Cross-reactivity was analysed further, and apparently N. americanus-specific epitopes identified, by immunoblotting. These observations could have considerable bearing on the interpretation of data from sero-epidemiological studies which failed to take account of concurrent infection with these parasites.

AB - Sero-epidemiological data are presented in which antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides has been investigated in a community in Papua New Guinea infected predominantly with N. americanus. It is our contention that the antigenic cross-reactivity which undoubtedly exists between these species accounted for (i) a peak in antibody levels against N. americanus in 10-13 years old children (driven by infection with A. lumbricoides), and (ii) the maintenance of apparent antibody levels against A. lumbricoides in older age groups (driven by infection with N. americanus in the absence of overt infection with A. lumbricoides). Cross-reactivity was analysed further, and apparently N. americanus-specific epitopes identified, by immunoblotting. These observations could have considerable bearing on the interpretation of data from sero-epidemiological studies which failed to take account of concurrent infection with these parasites.

U2 - 10.1016/0035-9203(91)90239-U

DO - 10.1016/0035-9203(91)90239-U

M3 - Journal article

VL - 85

SP - 511

EP - 514

JO - Transactions of The Royal Society of Tropical Medicine and Hygiene

JF - Transactions of The Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 4

ER -