Home > Research > Publications & Outputs > APOE-ε4 associates with hippocampal volume, lea...

Associated organisational unit

Electronic data

  • Manuscript_revised_2_FINAL_marked

    Rights statement: This is the author’s version of a work that was accepted for publication in Alzheimer's & Dementia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Alzheimer's & Dementia, 14, 9, 2018 DOI: 10.1016/j.jalz.2018.04.005

    Accepted author manuscript, 533 KB, PDF document

    Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Links

Text available via DOI:

View graph of relations

APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies

Research output: Contribution to journalJournal articlepeer-review

Published

Standard

APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies. / Saeed, Usman; Mirza, Saira S.; MacIntosh, Bradley J.; Herrmann, Nathan; Keith, Julia; Ramirez, Joel; Nestor, Sean M.; Yu, Qinggang; Knight, Jo; Swardfager, Walter; Potkin, Steven G.; Rogaeva, Ekaterina; George-Hyslop, Peter St.; Black, Sandra E.; Masellis, Mario.

In: Alzheimer's and Dementia, Vol. 14, No. 9, 09.2018, p. 1137-1147.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Saeed, U, Mirza, SS, MacIntosh, BJ, Herrmann, N, Keith, J, Ramirez, J, Nestor, SM, Yu, Q, Knight, J, Swardfager, W, Potkin, SG, Rogaeva, E, George-Hyslop, PS, Black, SE & Masellis, M 2018, 'APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies', Alzheimer's and Dementia, vol. 14, no. 9, pp. 1137-1147. https://doi.org/10.1016/j.jalz.2018.04.005

APA

Saeed, U., Mirza, S. S., MacIntosh, B. J., Herrmann, N., Keith, J., Ramirez, J., Nestor, S. M., Yu, Q., Knight, J., Swardfager, W., Potkin, S. G., Rogaeva, E., George-Hyslop, P. S., Black, S. E., & Masellis, M. (2018). APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies. Alzheimer's and Dementia, 14(9), 1137-1147. https://doi.org/10.1016/j.jalz.2018.04.005

Vancouver

Saeed U, Mirza SS, MacIntosh BJ, Herrmann N, Keith J, Ramirez J et al. APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies. Alzheimer's and Dementia. 2018 Sep;14(9):1137-1147. https://doi.org/10.1016/j.jalz.2018.04.005

Author

Saeed, Usman ; Mirza, Saira S. ; MacIntosh, Bradley J. ; Herrmann, Nathan ; Keith, Julia ; Ramirez, Joel ; Nestor, Sean M. ; Yu, Qinggang ; Knight, Jo ; Swardfager, Walter ; Potkin, Steven G. ; Rogaeva, Ekaterina ; George-Hyslop, Peter St. ; Black, Sandra E. ; Masellis, Mario. / APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies. In: Alzheimer's and Dementia. 2018 ; Vol. 14, No. 9. pp. 1137-1147.

Bibtex

@article{b2373ff178c349a280c6d678075bd5cf,
title = "APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies",
abstract = "Introduction Although the apolipoprotein E ε4-allele (APOE-ε4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. Methods We studied 298 patients (AD = 250, DLB = 48; 38 autopsy confirmed; NCT01800214) using neuropsychological testing, volumetric magnetic resonance imaging, and APOE genotyping to investigate the association of APOE-ε4 with hippocampal volume and learning/memory phenotypes, irrespective of diagnosis. Results Across the AD/DLB spectrum: (1) hippocampal volumes were smaller with increasing APOE-ε4 dosage (no genotype × diagnosis interaction observed), (2) learning performance as assessed by total recall scores was associated with hippocampal volumes only among APOE-ε4 carriers, and (3) APOE-ε4 carriers performed worse on long-delay free word recall. Discussion These findings provide evidence that APOE-ε4 is linked to hippocampal atrophy and learning/memory phenotypes across the AD/DLB spectrum, which could be useful as biomarkers of disease progression in therapeutic trials of mixed disease.",
keywords = "APOE, MRI, Hippocampus, Alzheimer's disease, Dementia with Lewy bodies, Learning, Memory, Endophenotype",
author = "Usman Saeed and Mirza, {Saira S.} and MacIntosh, {Bradley J.} and Nathan Herrmann and Julia Keith and Joel Ramirez and Nestor, {Sean M.} and Qinggang Yu and Jo Knight and Walter Swardfager and Potkin, {Steven G.} and Ekaterina Rogaeva and George-Hyslop, {Peter St.} and Black, {Sandra E.} and Mario Masellis",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Alzheimer's & Dementia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Alzheimer's & Dementia, 14, 9, 2018 DOI: 10.1016/j.jalz.2018.04.005",
year = "2018",
month = sep,
doi = "10.1016/j.jalz.2018.04.005",
language = "English",
volume = "14",
pages = "1137--1147",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies

AU - Saeed, Usman

AU - Mirza, Saira S.

AU - MacIntosh, Bradley J.

AU - Herrmann, Nathan

AU - Keith, Julia

AU - Ramirez, Joel

AU - Nestor, Sean M.

AU - Yu, Qinggang

AU - Knight, Jo

AU - Swardfager, Walter

AU - Potkin, Steven G.

AU - Rogaeva, Ekaterina

AU - George-Hyslop, Peter St.

AU - Black, Sandra E.

AU - Masellis, Mario

N1 - This is the author’s version of a work that was accepted for publication in Alzheimer's & Dementia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Alzheimer's & Dementia, 14, 9, 2018 DOI: 10.1016/j.jalz.2018.04.005

PY - 2018/9

Y1 - 2018/9

N2 - Introduction Although the apolipoprotein E ε4-allele (APOE-ε4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. Methods We studied 298 patients (AD = 250, DLB = 48; 38 autopsy confirmed; NCT01800214) using neuropsychological testing, volumetric magnetic resonance imaging, and APOE genotyping to investigate the association of APOE-ε4 with hippocampal volume and learning/memory phenotypes, irrespective of diagnosis. Results Across the AD/DLB spectrum: (1) hippocampal volumes were smaller with increasing APOE-ε4 dosage (no genotype × diagnosis interaction observed), (2) learning performance as assessed by total recall scores was associated with hippocampal volumes only among APOE-ε4 carriers, and (3) APOE-ε4 carriers performed worse on long-delay free word recall. Discussion These findings provide evidence that APOE-ε4 is linked to hippocampal atrophy and learning/memory phenotypes across the AD/DLB spectrum, which could be useful as biomarkers of disease progression in therapeutic trials of mixed disease.

AB - Introduction Although the apolipoprotein E ε4-allele (APOE-ε4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. Methods We studied 298 patients (AD = 250, DLB = 48; 38 autopsy confirmed; NCT01800214) using neuropsychological testing, volumetric magnetic resonance imaging, and APOE genotyping to investigate the association of APOE-ε4 with hippocampal volume and learning/memory phenotypes, irrespective of diagnosis. Results Across the AD/DLB spectrum: (1) hippocampal volumes were smaller with increasing APOE-ε4 dosage (no genotype × diagnosis interaction observed), (2) learning performance as assessed by total recall scores was associated with hippocampal volumes only among APOE-ε4 carriers, and (3) APOE-ε4 carriers performed worse on long-delay free word recall. Discussion These findings provide evidence that APOE-ε4 is linked to hippocampal atrophy and learning/memory phenotypes across the AD/DLB spectrum, which could be useful as biomarkers of disease progression in therapeutic trials of mixed disease.

KW - APOE

KW - MRI

KW - Hippocampus

KW - Alzheimer's disease

KW - Dementia with Lewy bodies

KW - Learning

KW - Memory

KW - Endophenotype

U2 - 10.1016/j.jalz.2018.04.005

DO - 10.1016/j.jalz.2018.04.005

M3 - Journal article

VL - 14

SP - 1137

EP - 1147

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

IS - 9

ER -