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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Arterial ischemic stroke in HIV
T2 - Defining and classifying etiology for research studies.
AU - Benjamin, LA
AU - Bryer, A
AU - Lucas, S
AU - Stanley, A
AU - Allain, TJ
AU - Joekes, E
AU - Emsley, Hedley
AU - Turnbull, I
AU - Downey, C
AU - Toh, CH
AU - Brown, K
AU - Brown, D
AU - Ison, C
AU - Smith, C
AU - Corbett, EL
AU - Nath, A
AU - Heyderman, RS
AU - Connor, MD
AU - Solomon, T
PY - 2016/8/1
Y1 - 2016/8/1
N2 - HIV infection, and potentially its treatment, increases the risk of an arterial ischemic stroke. Multiple etiologies and lack of clear case definitions inhibit progress in this field. Several etiologies, many treatable, are relevant to HIV-related stroke. To fully understand the mechanisms and the terminology used, a robust classification algorithm to help ascribe the various etiologies is needed. This consensus paper considers the strengths and limitations of current case definitions in the context of HIV infection. The case definitions for the major etiologies in HIV-related strokes were refined (e.g., varicella zoster vasculopathy and antiphospholipid syndrome) and in some instances new case definitions were described (e.g., HIV-associated vasculopathy). These case definitions provided a framework for an algorithm to help assign a final diagnosis, and help classify the subtypes of HIV etiology in ischemic stroke.
AB - HIV infection, and potentially its treatment, increases the risk of an arterial ischemic stroke. Multiple etiologies and lack of clear case definitions inhibit progress in this field. Several etiologies, many treatable, are relevant to HIV-related stroke. To fully understand the mechanisms and the terminology used, a robust classification algorithm to help ascribe the various etiologies is needed. This consensus paper considers the strengths and limitations of current case definitions in the context of HIV infection. The case definitions for the major etiologies in HIV-related strokes were refined (e.g., varicella zoster vasculopathy and antiphospholipid syndrome) and in some instances new case definitions were described (e.g., HIV-associated vasculopathy). These case definitions provided a framework for an algorithm to help assign a final diagnosis, and help classify the subtypes of HIV etiology in ischemic stroke.
UR - http://europepmc.org/abstract/med/27386505
U2 - 10.1212/NXI.0000000000000254
DO - 10.1212/NXI.0000000000000254
M3 - Journal article
C2 - 27386505
VL - 3
JO - Neurology Neuroimmunology and Neuroinflammation
JF - Neurology Neuroimmunology and Neuroinflammation
SN - 2332-7812
IS - 4
M1 - e254
ER -