Final published version
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Assessing artificial intelligence enabled liquid‐based cytology for triaging HPV ‐positive women: a population‐based cross‐sectional study
AU - Xue, Peng
AU - Xu, Hai‐Miao
AU - Tang, Hong‐Ping
AU - Wu, Wen‐Qing
AU - Seery, Samuel
AU - Han, Xiao
AU - Ye, Hu
AU - Jiang, Yu
AU - Qiao, You‐Lin
PY - 2023/8/31
Y1 - 2023/8/31
N2 - Introduction: Cytology‐based triaging is commonly used to manage the care of women with positive human papillomavirus (HPV) results, but it suffers from subjectivity and a lack of sensitivity and reproducibility. The diagnostic performance of an artificial intelligence‐enabled liquid‐based cytology (AI‐LBC) triage approach remains unclear. Here, we compared the clinical performance of AI‐LBC, human cytologists and HPV16/18 genotyping at triaging HPV‐positive women. Material and methods: HPV‐positive women were triaged using AI‐LBC, human cytologists and HPV16/18 genotyping. Histologically confirmed cervical intraepithelial neoplasia grade 2/3 or higher (CIN2+/CIN3+) were accepted as thresholds for clinical performance assessments. Results: Of the 3514 women included, 13.9% (n = 489) were HPV‐positive. The sensitivity of AI‐LBC was comparable to that of cytologists (86.49% vs 83.78%, P = 0.744) but substantially higher than HPV16/18 typing at detecting CIN2+ (86.49% vs 54.05%, P = 0.002). While the specificity of AI‐LBC was significantly lower than HPV16/18 typing (51.33% vs 87.17%, P < 0.001), it was significantly higher than cytologists at detecting CIN2+ (51.33% vs 40.93%, P < 0.001). AI‐LBC reduced referrals to colposcopy by approximately 10%, compared with cytologists (51.53% vs 60.94%, P = 0.003). Similar patterns were also observed for CIN3+. Conclusions: AI‐LBC has equivalent sensitivity and higher specificity compared with cytologists, with more efficient colposcopy referrals for HPV‐positive women. AI‐LBC could be particularly useful in regions where experienced cytologists are few in number. Further investigations are needed to determine triaging performance through prospective designs.
AB - Introduction: Cytology‐based triaging is commonly used to manage the care of women with positive human papillomavirus (HPV) results, but it suffers from subjectivity and a lack of sensitivity and reproducibility. The diagnostic performance of an artificial intelligence‐enabled liquid‐based cytology (AI‐LBC) triage approach remains unclear. Here, we compared the clinical performance of AI‐LBC, human cytologists and HPV16/18 genotyping at triaging HPV‐positive women. Material and methods: HPV‐positive women were triaged using AI‐LBC, human cytologists and HPV16/18 genotyping. Histologically confirmed cervical intraepithelial neoplasia grade 2/3 or higher (CIN2+/CIN3+) were accepted as thresholds for clinical performance assessments. Results: Of the 3514 women included, 13.9% (n = 489) were HPV‐positive. The sensitivity of AI‐LBC was comparable to that of cytologists (86.49% vs 83.78%, P = 0.744) but substantially higher than HPV16/18 typing at detecting CIN2+ (86.49% vs 54.05%, P = 0.002). While the specificity of AI‐LBC was significantly lower than HPV16/18 typing (51.33% vs 87.17%, P < 0.001), it was significantly higher than cytologists at detecting CIN2+ (51.33% vs 40.93%, P < 0.001). AI‐LBC reduced referrals to colposcopy by approximately 10%, compared with cytologists (51.53% vs 60.94%, P = 0.003). Similar patterns were also observed for CIN3+. Conclusions: AI‐LBC has equivalent sensitivity and higher specificity compared with cytologists, with more efficient colposcopy referrals for HPV‐positive women. AI‐LBC could be particularly useful in regions where experienced cytologists are few in number. Further investigations are needed to determine triaging performance through prospective designs.
KW - cytology
KW - cervical cancer screening
KW - artificial intelligence
KW - HPV triage
UR - http://www.scopus.com/inward/record.url?scp=85161900472&partnerID=8YFLogxK
U2 - 10.1111/aogs.14611
DO - 10.1111/aogs.14611
M3 - Journal article
VL - 102
SP - 1026
EP - 1033
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 8
ER -