Objectives: To examine the feasibility and acceptability of a novel telehealth (video‐conferencing software and telephone calls) imagery‐based therapeutic intervention for people experiencing persecutory delusions. Utilising a multiple baseline case series design and exploring imagery‐focused therapy for psychosis (iMAPS). Design: A non‐concurrent A‐B multiple baseline design was used. Methods: Participants experiencing persecutory delusions and self‐reporting a psychosis or schizophrenia‐spectrum diagnosis were recruited through online adverts. On completion of assessments, participants were randomly assigned to multiple baseline assessments, of between three and five sessions. Six therapy sessions followed, consisting of imagery formulation, safe‐place imagery creation, compassionate imagery, imagery manipulation and rescripting. Participants completed pre‐ and post‐measures and sessional measures via an online survey software or in semi‐structured interviews. Two weeks post‐intervention, a final measure was completed exploring any potential adverse effects of psychotherapy. Results: Five female participants completed all baseline and therapeutic sessions, suggesting the therapy was and mode of delivery was feasible and acceptable. Results indicate strong effect sizes across PANSS positive subscale and mood, as well as participants reporting a clinically significant change in at least one measure, for example, PSYRATS. All participants reported a reduction in the realness and compelling nature of distressing imagery. Conclusions: Results suggest delivering a telehealth imagery‐focused therapy is acceptable and feasibly delivered via telehealth. A control group and blinding of assessments would strengthen the methodological limitations present.