Final published version
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed) › peer-review
Assessment of the Oral Bioavailability of Organic Contaminants in Humans. / Wijayawardena, M.A.A.; Liu, Y.; Yan, K. et al.
Bioavailability of Organic Chemicals in Soil and Sediment . ed. / Jose Julio Ortega-Calvo; John Robert Parsons. Cham : Springer, 2020. p. 191-218 (Handbook of Environmental Chemistry; Vol. 100).Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed) › peer-review
}
TY - CHAP
T1 - Assessment of the Oral Bioavailability of Organic Contaminants in Humans
AU - Wijayawardena, M.A.A.
AU - Liu, Y.
AU - Yan, K.
AU - Duan, L.
AU - Umeh, A.C.
AU - Naidu, R.
AU - Semple, K.T.
PY - 2020/7/9
Y1 - 2020/7/9
N2 - Bioavailability estimates the actual internal uptake or absorption of contaminants that enter the body (internal dose) and helps in providing a more accurate estimation of the human risks than the usage of total concentration. This is important for exposure assessment for children in relation to their hand-to-mouth activities. For example significant reductions of the bioavailability of long-term contaminated soils have been demonstrated using various animal models. The measurement for bioavailability involves various uncertainties for organic contaminants. It is crucial to determine the parameters that influence the results of bioavailability. This chapter provides a summary of the current state of knowledge for the determination of bioavailability for a range of organic contaminants. The information provided will be useful in facilitating further research efforts for the investigation of bioavailability of contaminants in conducting exposure assessments.
AB - Bioavailability estimates the actual internal uptake or absorption of contaminants that enter the body (internal dose) and helps in providing a more accurate estimation of the human risks than the usage of total concentration. This is important for exposure assessment for children in relation to their hand-to-mouth activities. For example significant reductions of the bioavailability of long-term contaminated soils have been demonstrated using various animal models. The measurement for bioavailability involves various uncertainties for organic contaminants. It is crucial to determine the parameters that influence the results of bioavailability. This chapter provides a summary of the current state of knowledge for the determination of bioavailability for a range of organic contaminants. The information provided will be useful in facilitating further research efforts for the investigation of bioavailability of contaminants in conducting exposure assessments.
KW - Bioaccumulation
KW - Bioavailability
KW - Diffusion
KW - Dissolution
KW - Electrophilic
KW - Perfusion rate
KW - Permeability rate
U2 - 10.1007/698_2020_596
DO - 10.1007/698_2020_596
M3 - Chapter (peer-reviewed)
SN - 9783030579180
T3 - Handbook of Environmental Chemistry
SP - 191
EP - 218
BT - Bioavailability of Organic Chemicals in Soil and Sediment
A2 - Ortega-Calvo, Jose Julio
A2 - Parsons, John Robert
PB - Springer
CY - Cham
ER -