The present study numerically investigates the optimization of thermal performance in a dimpled channel using a promising genre of nanofluid which is equipped with the inclusion of two-dimensional (2D) MXene (Ti3C2) nanoparticles to the soybean oil. The stream-wise and span-wise variation of the spherical dimples was kept 3.00 and 3.15 over the flow domain with an elongation of 2.5 mm. The detailed evaluation of both the local and global parameters is carried out for 0.025%, 0.075%, and 0.125% mass concentrations of MXene. The Reynolds number is varied from 1000 to 6000 to understand the effect of both the laminar and turbulent flow characteristics in predicting the thermal performance. The simulations are carried out using finite volume method (FVM) under constant heat flux, assuming the mixture of nanoparticles as homogeneous mixture. The results show that with the increase in the mass concentration of nanoparticles, thermal performances of the nanofluid increase. However, it is also identified that with the increase in Reynolds number, the thermal performance increases under turbulent flow regime. On the contrary, thermal performance was observed to be decreased with the increase in Reynolds number under laminar flow regime. An astounding improvement in 88.9% thermal performance is found for 0.125% mass concentrations of soybean-based MXene nanofluid which exclusively indicates the credibility of MXene nanofluid as a next generation potential candidate for heat exchanger industries.