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Association of the serotonin transporter gene, neuroticism and smoking behaviours

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Association of the serotonin transporter gene, neuroticism and smoking behaviours. / O'Gara, Colin; Knight, Jo; Stapleton, John et al.

In: Journal of Human Genetics , Vol. 53, No. 3, 2008, p. 239-246.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

O'Gara, C, Knight, J, Stapleton, J, Luty, J, Neale, B, Nash, M, Heuzo-Diaz, P, Hoda, F, Cohen, S, Sutherland, G, Collier, D, Sham, P, Ball, D, McGuffin, P & Craig, I 2008, 'Association of the serotonin transporter gene, neuroticism and smoking behaviours', Journal of Human Genetics , vol. 53, no. 3, pp. 239-246. https://doi.org/10.1007/s10038-007-0243-1

APA

O'Gara, C., Knight, J., Stapleton, J., Luty, J., Neale, B., Nash, M., Heuzo-Diaz, P., Hoda, F., Cohen, S., Sutherland, G., Collier, D., Sham, P., Ball, D., McGuffin, P., & Craig, I. (2008). Association of the serotonin transporter gene, neuroticism and smoking behaviours. Journal of Human Genetics , 53(3), 239-246. https://doi.org/10.1007/s10038-007-0243-1

Vancouver

O'Gara C, Knight J, Stapleton J, Luty J, Neale B, Nash M et al. Association of the serotonin transporter gene, neuroticism and smoking behaviours. Journal of Human Genetics . 2008;53(3):239-246. Epub 2008 Jan 10. doi: 10.1007/s10038-007-0243-1

Author

O'Gara, Colin ; Knight, Jo ; Stapleton, John et al. / Association of the serotonin transporter gene, neuroticism and smoking behaviours. In: Journal of Human Genetics . 2008 ; Vol. 53, No. 3. pp. 239-246.

Bibtex

@article{7f15f9af33de4d48807df67896978ef7,
title = "Association of the serotonin transporter gene, neuroticism and smoking behaviours",
abstract = "Cigarette consumption and smoking cessation are influenced in part by genes. Personality traits have also been implicated in the aetiology of smoking. Neuroticism, a personality trait with a heritable component, correlates well with anxiety and depression, increasing the risk of being a smoker and decreasing the chance of smoking cessation. Several prior studies in non-British populations have given conflicting results as to whether some genetic polymorphisms affect the relationship between smoking and neuroticism. This study investigated the influence of serotonin transporter (5HTTLPR) genotypes on a composite measure of neuroticism and cigarette consumption/smoking cessation in a British population. Although neuroticism was significantly associated with cigarette consumption and smoking cessation, genotype did not affect this relationship. Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings.",
keywords = "Confidence Intervals, Gene Frequency, Genotype, Humans, Neurotic Disorders, Personality, Quantitative Trait Loci, Regression Analysis, Serotonin Plasma Membrane Transport Proteins, Smoking, Smoking Cessation",
author = "Colin O'Gara and Jo Knight and John Stapleton and Jason Luty and Ben Neale and Matt Nash and Patricia Heuzo-Diaz and Farzana Hoda and Sarah Cohen and Gay Sutherland and David Collier and Pak Sham and David Ball and Peter McGuffin and Ian Craig",
year = "2008",
doi = "10.1007/s10038-007-0243-1",
language = "English",
volume = "53",
pages = "239--246",
journal = "Journal of Human Genetics ",
issn = "1434-5161",
publisher = "Nature Publishing Group",
number = "3",

}

RIS

TY - JOUR

T1 - Association of the serotonin transporter gene, neuroticism and smoking behaviours

AU - O'Gara, Colin

AU - Knight, Jo

AU - Stapleton, John

AU - Luty, Jason

AU - Neale, Ben

AU - Nash, Matt

AU - Heuzo-Diaz, Patricia

AU - Hoda, Farzana

AU - Cohen, Sarah

AU - Sutherland, Gay

AU - Collier, David

AU - Sham, Pak

AU - Ball, David

AU - McGuffin, Peter

AU - Craig, Ian

PY - 2008

Y1 - 2008

N2 - Cigarette consumption and smoking cessation are influenced in part by genes. Personality traits have also been implicated in the aetiology of smoking. Neuroticism, a personality trait with a heritable component, correlates well with anxiety and depression, increasing the risk of being a smoker and decreasing the chance of smoking cessation. Several prior studies in non-British populations have given conflicting results as to whether some genetic polymorphisms affect the relationship between smoking and neuroticism. This study investigated the influence of serotonin transporter (5HTTLPR) genotypes on a composite measure of neuroticism and cigarette consumption/smoking cessation in a British population. Although neuroticism was significantly associated with cigarette consumption and smoking cessation, genotype did not affect this relationship. Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings.

AB - Cigarette consumption and smoking cessation are influenced in part by genes. Personality traits have also been implicated in the aetiology of smoking. Neuroticism, a personality trait with a heritable component, correlates well with anxiety and depression, increasing the risk of being a smoker and decreasing the chance of smoking cessation. Several prior studies in non-British populations have given conflicting results as to whether some genetic polymorphisms affect the relationship between smoking and neuroticism. This study investigated the influence of serotonin transporter (5HTTLPR) genotypes on a composite measure of neuroticism and cigarette consumption/smoking cessation in a British population. Although neuroticism was significantly associated with cigarette consumption and smoking cessation, genotype did not affect this relationship. Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings.

KW - Confidence Intervals

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Neurotic Disorders

KW - Personality

KW - Quantitative Trait Loci

KW - Regression Analysis

KW - Serotonin Plasma Membrane Transport Proteins

KW - Smoking

KW - Smoking Cessation

U2 - 10.1007/s10038-007-0243-1

DO - 10.1007/s10038-007-0243-1

M3 - Journal article

C2 - 18188666

VL - 53

SP - 239

EP - 246

JO - Journal of Human Genetics

JF - Journal of Human Genetics

SN - 1434-5161

IS - 3

ER -