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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Associations between childhood maltreatment and inflammatory markers.
AU - Palmos, AB
AU - Watson, S
AU - Hughes, T
AU - Finkelmeyer, A
AU - McAllister-Williams, RH
AU - Ferrier, N
AU - Anderson, IM
AU - Nair, R
AU - Young, AH
AU - Strawbridge, R
AU - Cleare, AJ
AU - Chung, R
AU - Frissa, S
AU - Goodwin, Laura
AU - Hotopf, Matthew
AU - Hatch, Stephani L.
AU - Wang, Hong
AU - Collier, David A
AU - Thuret, Sandrine
AU - Breen, Gerome
AU - Powell, Timothy R
PY - 2019/1/31
Y1 - 2019/1/31
N2 - BackgroundChildhood maltreatment is one of the strongest predictors of adulthood depression and alterations to circulating levels of inflammatory markers is one putative mechanism mediating risk or resilience.AimsTo determine the effects of childhood maltreatment on circulating levels of 41 inflammatory markers in healthy individuals and those with a major depressive disorder (MDD) diagnosis.MethodWe investigated the association of childhood maltreatment with levels of 41 inflammatory markers in two groups, 164 patients with MDD and 301 controls, using multiplex electrochemiluminescence methods applied to blood serum.ResultsChildhood maltreatment was not associated with altered inflammatory markers in either group after multiple testing correction. Body mass index (BMI) exerted strong effects on interleukin-6 and C-reactive protein levels in those with MDD.ConclusionsChildhood maltreatment did not exert effects on inflammatory marker levels in either the participants with MDD or the control group in our study. Our results instead highlight the more pertinent influence of BMI.
AB - BackgroundChildhood maltreatment is one of the strongest predictors of adulthood depression and alterations to circulating levels of inflammatory markers is one putative mechanism mediating risk or resilience.AimsTo determine the effects of childhood maltreatment on circulating levels of 41 inflammatory markers in healthy individuals and those with a major depressive disorder (MDD) diagnosis.MethodWe investigated the association of childhood maltreatment with levels of 41 inflammatory markers in two groups, 164 patients with MDD and 301 controls, using multiplex electrochemiluminescence methods applied to blood serum.ResultsChildhood maltreatment was not associated with altered inflammatory markers in either group after multiple testing correction. Body mass index (BMI) exerted strong effects on interleukin-6 and C-reactive protein levels in those with MDD.ConclusionsChildhood maltreatment did not exert effects on inflammatory marker levels in either the participants with MDD or the control group in our study. Our results instead highlight the more pertinent influence of BMI.
U2 - 10.1192/bjo.2018.80
DO - 10.1192/bjo.2018.80
M3 - Journal article
C2 - 30762500
VL - 5
JO - BJPsych Open
JF - BJPsych Open
SN - 2056-4724
IS - 1
M1 - e3
ER -