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Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs.

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Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs. / Yuen Fong, Chun; Law, Wai Him Crystal ; Fahrenfort, Johannes Jacobus et al.

In: The Journal of Headache and Pain, Vol. 23, No. 1, 44, 01.04.2022.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Yuen Fong, C, Law, WHC, Fahrenfort, JJ, Braithwaite, JJ & Mazaheri, A 2022, 'Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs.', The Journal of Headache and Pain, vol. 23, no. 1, 44. https://doi.org/10.1186/s10194-022-01410-2

APA

Yuen Fong, C., Law, W. H. C., Fahrenfort, J. J., Braithwaite, J. J., & Mazaheri, A. (2022). Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs. The Journal of Headache and Pain, 23(1), [44]. https://doi.org/10.1186/s10194-022-01410-2

Vancouver

Yuen Fong C, Law WHC, Fahrenfort JJ, Braithwaite JJ, Mazaheri A. Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs. The Journal of Headache and Pain. 2022 Apr 1;23(1):44. doi: 10.1186/s10194-022-01410-2

Author

Yuen Fong, Chun ; Law, Wai Him Crystal ; Fahrenfort, Johannes Jacobus et al. / Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs. In: The Journal of Headache and Pain. 2022 ; Vol. 23, No. 1.

Bibtex

@article{76f813fee2084364b8eaaf5b5ecf932a,
title = "Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs.",
abstract = "Background: Anomalous phantom visual perceptions coupled to an aversion and discomfort to some visual patterns (especially grating in mid-range spatial frequency) have been associated with the hyperresponsiveness in migraine patients. Previous literature has found fluctuations of alpha oscillation (8-14 Hz) over the visual cortex to be associated with the gating of the visual stream. In the current study, we examined whether alpha activity was differentially modulated in migraineurs in anticipation of an upcoming stimulus as well as post-stimulus periods. Methods: We used EEG to examine the brain activity in a group of 28 migraineurs (17 with aura/11 without) and 29 non-migraineurs and compared their alpha power in the pre/post-stimulus period relative to the onset of stripped gratings. Results: Overall, we found that migraineurs had significantly less alpha power prior to the onset of the stimulus relative to controls. Moreover, migraineurs had significantly greater post-stimulus alpha suppression (i.e event-related desynchronization) induced by the grating in 3 cycles per degree at the 2nd half of the experiment. Conclusions: These findings taken together provide strong support for the presence of the hyperresponsiveness of the visual cortex of migraine sufferers. We speculate that it could be the consequence of impaired perceptual learning driven by the dysfunction of GABAergic inhibitory mechanism. ",
keywords = "migraine, pattern glare, alpha, hyperexcitability, perceptual learning",
author = "{Yuen Fong}, Chun and Law, {Wai Him Crystal} and Fahrenfort, {Johannes Jacobus} and Braithwaite, {J. J.} and Ali Mazaheri",
year = "2022",
month = apr,
day = "1",
doi = "10.1186/s10194-022-01410-2",
language = "English",
volume = "23",
journal = "The Journal of Headache and Pain",
number = "1",

}

RIS

TY - JOUR

T1 - Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs.

AU - Yuen Fong, Chun

AU - Law, Wai Him Crystal

AU - Fahrenfort, Johannes Jacobus

AU - Braithwaite, J. J.

AU - Mazaheri, Ali

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Background: Anomalous phantom visual perceptions coupled to an aversion and discomfort to some visual patterns (especially grating in mid-range spatial frequency) have been associated with the hyperresponsiveness in migraine patients. Previous literature has found fluctuations of alpha oscillation (8-14 Hz) over the visual cortex to be associated with the gating of the visual stream. In the current study, we examined whether alpha activity was differentially modulated in migraineurs in anticipation of an upcoming stimulus as well as post-stimulus periods. Methods: We used EEG to examine the brain activity in a group of 28 migraineurs (17 with aura/11 without) and 29 non-migraineurs and compared their alpha power in the pre/post-stimulus period relative to the onset of stripped gratings. Results: Overall, we found that migraineurs had significantly less alpha power prior to the onset of the stimulus relative to controls. Moreover, migraineurs had significantly greater post-stimulus alpha suppression (i.e event-related desynchronization) induced by the grating in 3 cycles per degree at the 2nd half of the experiment. Conclusions: These findings taken together provide strong support for the presence of the hyperresponsiveness of the visual cortex of migraine sufferers. We speculate that it could be the consequence of impaired perceptual learning driven by the dysfunction of GABAergic inhibitory mechanism.

AB - Background: Anomalous phantom visual perceptions coupled to an aversion and discomfort to some visual patterns (especially grating in mid-range spatial frequency) have been associated with the hyperresponsiveness in migraine patients. Previous literature has found fluctuations of alpha oscillation (8-14 Hz) over the visual cortex to be associated with the gating of the visual stream. In the current study, we examined whether alpha activity was differentially modulated in migraineurs in anticipation of an upcoming stimulus as well as post-stimulus periods. Methods: We used EEG to examine the brain activity in a group of 28 migraineurs (17 with aura/11 without) and 29 non-migraineurs and compared their alpha power in the pre/post-stimulus period relative to the onset of stripped gratings. Results: Overall, we found that migraineurs had significantly less alpha power prior to the onset of the stimulus relative to controls. Moreover, migraineurs had significantly greater post-stimulus alpha suppression (i.e event-related desynchronization) induced by the grating in 3 cycles per degree at the 2nd half of the experiment. Conclusions: These findings taken together provide strong support for the presence of the hyperresponsiveness of the visual cortex of migraine sufferers. We speculate that it could be the consequence of impaired perceptual learning driven by the dysfunction of GABAergic inhibitory mechanism.

KW - migraine

KW - pattern glare

KW - alpha

KW - hyperexcitability

KW - perceptual learning

U2 - 10.1186/s10194-022-01410-2

DO - 10.1186/s10194-022-01410-2

M3 - Journal article

VL - 23

JO - The Journal of Headache and Pain

JF - The Journal of Headache and Pain

IS - 1

M1 - 44

ER -