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Autophagy in protists

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Autophagy in protists. / Duszenko, M.; Ginger, Michael L.; Brennand, A. et al.
In: Autophagy, Vol. 7, No. 2, 02.2011, p. 127-158.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Duszenko, M, Ginger, ML, Brennand, A, Gualdron-Lopez, M, Colombo, M-I, Coombs, GH, Coppens, I, Jayabalasingham, B, Langsley, G, Lisboa de Castro, S, Menna-Barreto, R, Mottram, JC, Navarro, M, Rigden, DJ, Romana, P, Stoka, V, Turk, B & Michels, PAM 2011, 'Autophagy in protists', Autophagy, vol. 7, no. 2, pp. 127-158. <http://www.landesbioscience.com/journals/autophagy/article/13310>

APA

Duszenko, M., Ginger, M. L., Brennand, A., Gualdron-Lopez, M., Colombo, M.-I., Coombs, G. H., Coppens, I., Jayabalasingham, B., Langsley, G., Lisboa de Castro, S., Menna-Barreto, R., Mottram, J. C., Navarro, M., Rigden, D. J., Romana, P., Stoka, V., Turk, B., & Michels, P. A. M. (2011). Autophagy in protists. Autophagy, 7(2), 127-158. http://www.landesbioscience.com/journals/autophagy/article/13310

Vancouver

Duszenko M, Ginger ML, Brennand A, Gualdron-Lopez M, Colombo MI, Coombs GH et al. Autophagy in protists. Autophagy. 2011 Feb;7(2):127-158.

Author

Duszenko, M. ; Ginger, Michael L. ; Brennand, A. et al. / Autophagy in protists. In: Autophagy. 2011 ; Vol. 7, No. 2. pp. 127-158.

Bibtex

@article{c47cb0e1026c48cdbe101811cdda7527,
title = "Autophagy in protists",
abstract = "Autophagy is the degradative process by which eukaryotic cells digest their own components using acid hydrolases within the lysosome. Originally thought to function almost exclusively in providing starving cells with nutrients taken from their own cellular constituents, autophagy is in fact involved in numerous cellular events including differentiation, turnover of macromolecules and organelles and defense against parasitic invaders. During the past 10-20 years, molecular components of the autophagic machinery have been discovered, revealing a complex interactome of proteins and lipids, which, in a concerted way, induce membrane formation to engulf cellular material and target it for lysosomal degradation. Here, our emphasis is autophagy in protists. We discuss experimental and genomic data indicating that the canonical autophagy machinery characterized in animals and fungi appeared prior to the radiation of major eukaryotic lineages. Moreover, we describe how comparative bioinformatics revealed that this canonical machinery has been subject to moderation, outright loss or elaboration on multiple occasions in protist lineages, most probably as a consequence of diverse lifestyle adaptations. We also review experimental studies illustrating how several pathogenic protists either utilize autophagy mechanisms or manipulate host-cell autophagy in order to establish or maintain infection within a host. The essentiality of autophagy for the pathogenicity of many parasites, and the unique features of some of the autophagy-related proteins involved, suggest possible new targets for drug discovery. Further studies of the molecular details of autophagy in protists will undoubtedly enhance our understanding of the diversity and complexity of this cellular phenomenon and the opportunities it offers as a drug target.",
author = "M. Duszenko and Ginger, {Michael L.} and A. Brennand and M. Gualdron-Lopez and M.-I. Colombo and Coombs, {G. H.} and I. Coppens and B. Jayabalasingham and G. Langsley and {Lisboa de Castro}, S. and R. Menna-Barreto and Mottram, {J. C.} and M. Navarro and Rigden, {D. J.} and P. Romana and V. Stoka and B. Turk and Michels, {Paul A. M.}",
year = "2011",
month = feb,
language = "English",
volume = "7",
pages = "127--158",
journal = "Autophagy",
issn = "1554-8635",
publisher = "Landes Bioscience",
number = "2",

}

RIS

TY - JOUR

T1 - Autophagy in protists

AU - Duszenko, M.

AU - Ginger, Michael L.

AU - Brennand, A.

AU - Gualdron-Lopez, M.

AU - Colombo, M.-I.

AU - Coombs, G. H.

AU - Coppens, I.

AU - Jayabalasingham, B.

AU - Langsley, G.

AU - Lisboa de Castro, S.

AU - Menna-Barreto, R.

AU - Mottram, J. C.

AU - Navarro, M.

AU - Rigden, D. J.

AU - Romana, P.

AU - Stoka, V.

AU - Turk, B.

AU - Michels, Paul A. M.

PY - 2011/2

Y1 - 2011/2

N2 - Autophagy is the degradative process by which eukaryotic cells digest their own components using acid hydrolases within the lysosome. Originally thought to function almost exclusively in providing starving cells with nutrients taken from their own cellular constituents, autophagy is in fact involved in numerous cellular events including differentiation, turnover of macromolecules and organelles and defense against parasitic invaders. During the past 10-20 years, molecular components of the autophagic machinery have been discovered, revealing a complex interactome of proteins and lipids, which, in a concerted way, induce membrane formation to engulf cellular material and target it for lysosomal degradation. Here, our emphasis is autophagy in protists. We discuss experimental and genomic data indicating that the canonical autophagy machinery characterized in animals and fungi appeared prior to the radiation of major eukaryotic lineages. Moreover, we describe how comparative bioinformatics revealed that this canonical machinery has been subject to moderation, outright loss or elaboration on multiple occasions in protist lineages, most probably as a consequence of diverse lifestyle adaptations. We also review experimental studies illustrating how several pathogenic protists either utilize autophagy mechanisms or manipulate host-cell autophagy in order to establish or maintain infection within a host. The essentiality of autophagy for the pathogenicity of many parasites, and the unique features of some of the autophagy-related proteins involved, suggest possible new targets for drug discovery. Further studies of the molecular details of autophagy in protists will undoubtedly enhance our understanding of the diversity and complexity of this cellular phenomenon and the opportunities it offers as a drug target.

AB - Autophagy is the degradative process by which eukaryotic cells digest their own components using acid hydrolases within the lysosome. Originally thought to function almost exclusively in providing starving cells with nutrients taken from their own cellular constituents, autophagy is in fact involved in numerous cellular events including differentiation, turnover of macromolecules and organelles and defense against parasitic invaders. During the past 10-20 years, molecular components of the autophagic machinery have been discovered, revealing a complex interactome of proteins and lipids, which, in a concerted way, induce membrane formation to engulf cellular material and target it for lysosomal degradation. Here, our emphasis is autophagy in protists. We discuss experimental and genomic data indicating that the canonical autophagy machinery characterized in animals and fungi appeared prior to the radiation of major eukaryotic lineages. Moreover, we describe how comparative bioinformatics revealed that this canonical machinery has been subject to moderation, outright loss or elaboration on multiple occasions in protist lineages, most probably as a consequence of diverse lifestyle adaptations. We also review experimental studies illustrating how several pathogenic protists either utilize autophagy mechanisms or manipulate host-cell autophagy in order to establish or maintain infection within a host. The essentiality of autophagy for the pathogenicity of many parasites, and the unique features of some of the autophagy-related proteins involved, suggest possible new targets for drug discovery. Further studies of the molecular details of autophagy in protists will undoubtedly enhance our understanding of the diversity and complexity of this cellular phenomenon and the opportunities it offers as a drug target.

M3 - Journal article

VL - 7

SP - 127

EP - 158

JO - Autophagy

JF - Autophagy

SN - 1554-8635

IS - 2

ER -