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BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells. / Thomaz, Amanda; Jaeger, Mariane; Buendia, Marienela et al.
In: Journal of Molecular Neuroscience , Vol. 59, No. 3, 30.07.2016, p. 326-333.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Thomaz, A, Jaeger, M, Buendia, M, Bambini-Junior, V, Gregianin, LJ, Brunetto, AL, Brunetto, AT, de Farias, CB & Roesler, R 2016, 'BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells', Journal of Molecular Neuroscience , vol. 59, no. 3, pp. 326-333. https://doi.org/10.1007/s12031-015-0689-0

APA

Thomaz, A., Jaeger, M., Buendia, M., Bambini-Junior, V., Gregianin, L. J., Brunetto, A. L., Brunetto, A. T., de Farias, C. B., & Roesler, R. (2016). BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells. Journal of Molecular Neuroscience , 59(3), 326-333. https://doi.org/10.1007/s12031-015-0689-0

Vancouver

Thomaz A, Jaeger M, Buendia M, Bambini-Junior V, Gregianin LJ, Brunetto AL et al. BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells. Journal of Molecular Neuroscience . 2016 Jul 30;59(3):326-333. Epub 2015 Nov 27. doi: 10.1007/s12031-015-0689-0

Author

Thomaz, Amanda ; Jaeger, Mariane ; Buendia, Marienela et al. / BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors : Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells. In: Journal of Molecular Neuroscience . 2016 ; Vol. 59, No. 3. pp. 326-333.

Bibtex

@article{3526a0d7e5e84643a27829792a953a4a,
title = "BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells",
abstract = "Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Deregulation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signaling has been associated with increased proliferative capabilities, invasiveness, and chemoresistance in several types of cancer. However, the relevance of this pathway in MB remains unknown. Here, we show that the selective TrkB inhibitor N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide (ANA-12) markedly reduced the viability and survival of human cell lines representative of different MB molecular subgroups. These findings provide the first evidence supporting further investigation of TrkB inhibition as a potential novel strategy for MB treatment. ",
keywords = "Antineoplastic Agents/pharmacology, Azepines/pharmacology, Benzamides/pharmacology, Brain Neoplasms/metabolism, Brain-Derived Neurotrophic Factor/pharmacology, Cell Line, Tumor, Cell Proliferation/drug effects, Cell Survival/drug effects, Humans, Medulloblastoma/metabolism, Membrane Glycoproteins/antagonists & inhibitors, Protein Kinase Inhibitors/pharmacology, Protein-Tyrosine Kinases/antagonists & inhibitors, Receptor, trkB, Signal Transduction",
author = "Amanda Thomaz and Mariane Jaeger and Marienela Buendia and Victorio Bambini-Junior and Gregianin, {Lauro Jos{\'e}} and Brunetto, {Algemir Lunardi} and Brunetto, {Andr{\'e} T} and {de Farias}, {Caroline Brunetto} and Rafael Roesler",
year = "2016",
month = jul,
day = "30",
doi = "10.1007/s12031-015-0689-0",
language = "English",
volume = "59",
pages = "326--333",
journal = "Journal of Molecular Neuroscience ",
issn = "0895-8696",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors

T2 - Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells

AU - Thomaz, Amanda

AU - Jaeger, Mariane

AU - Buendia, Marienela

AU - Bambini-Junior, Victorio

AU - Gregianin, Lauro José

AU - Brunetto, Algemir Lunardi

AU - Brunetto, André T

AU - de Farias, Caroline Brunetto

AU - Roesler, Rafael

PY - 2016/7/30

Y1 - 2016/7/30

N2 - Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Deregulation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signaling has been associated with increased proliferative capabilities, invasiveness, and chemoresistance in several types of cancer. However, the relevance of this pathway in MB remains unknown. Here, we show that the selective TrkB inhibitor N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide (ANA-12) markedly reduced the viability and survival of human cell lines representative of different MB molecular subgroups. These findings provide the first evidence supporting further investigation of TrkB inhibition as a potential novel strategy for MB treatment.

AB - Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Deregulation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signaling has been associated with increased proliferative capabilities, invasiveness, and chemoresistance in several types of cancer. However, the relevance of this pathway in MB remains unknown. Here, we show that the selective TrkB inhibitor N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide (ANA-12) markedly reduced the viability and survival of human cell lines representative of different MB molecular subgroups. These findings provide the first evidence supporting further investigation of TrkB inhibition as a potential novel strategy for MB treatment.

KW - Antineoplastic Agents/pharmacology

KW - Azepines/pharmacology

KW - Benzamides/pharmacology

KW - Brain Neoplasms/metabolism

KW - Brain-Derived Neurotrophic Factor/pharmacology

KW - Cell Line, Tumor

KW - Cell Proliferation/drug effects

KW - Cell Survival/drug effects

KW - Humans

KW - Medulloblastoma/metabolism

KW - Membrane Glycoproteins/antagonists & inhibitors

KW - Protein Kinase Inhibitors/pharmacology

KW - Protein-Tyrosine Kinases/antagonists & inhibitors

KW - Receptor, trkB

KW - Signal Transduction

U2 - 10.1007/s12031-015-0689-0

DO - 10.1007/s12031-015-0689-0

M3 - Journal article

C2 - 26614346

VL - 59

SP - 326

EP - 333

JO - Journal of Molecular Neuroscience

JF - Journal of Molecular Neuroscience

SN - 0895-8696

IS - 3

ER -