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Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA

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Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA. / Hirsch, Mauro Mozael; Deckmann, Iohanna; Fontes-Dutra, Mellanie; Bauer-Negrini, Guilherme; Della-Flora Nunes, Gustavo; Nunes, Walquiria; Rabelo, Bruna; Riesgo, Rudimar; Margis, Rogerio; Bambini-Junior, Victorio; Gottfried, Carmem.

In: Food and Chemical Toxicology, Vol. 115, 31.05.2018, p. 336-343.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Hirsch, MM, Deckmann, I, Fontes-Dutra, M, Bauer-Negrini, G, Della-Flora Nunes, G, Nunes, W, Rabelo, B, Riesgo, R, Margis, R, Bambini-Junior, V & Gottfried, C 2018, 'Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA', Food and Chemical Toxicology, vol. 115, pp. 336-343. https://doi.org/10.1016/j.fct.2018.02.061

APA

Hirsch, M. M., Deckmann, I., Fontes-Dutra, M., Bauer-Negrini, G., Della-Flora Nunes, G., Nunes, W., Rabelo, B., Riesgo, R., Margis, R., Bambini-Junior, V., & Gottfried, C. (2018). Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA. Food and Chemical Toxicology, 115, 336-343. https://doi.org/10.1016/j.fct.2018.02.061

Vancouver

Hirsch MM, Deckmann I, Fontes-Dutra M, Bauer-Negrini G, Della-Flora Nunes G, Nunes W et al. Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA. Food and Chemical Toxicology. 2018 May 31;115:336-343. https://doi.org/10.1016/j.fct.2018.02.061

Author

Hirsch, Mauro Mozael ; Deckmann, Iohanna ; Fontes-Dutra, Mellanie ; Bauer-Negrini, Guilherme ; Della-Flora Nunes, Gustavo ; Nunes, Walquiria ; Rabelo, Bruna ; Riesgo, Rudimar ; Margis, Rogerio ; Bambini-Junior, Victorio ; Gottfried, Carmem. / Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA. In: Food and Chemical Toxicology. 2018 ; Vol. 115. pp. 336-343.

Bibtex

@article{b58e4acfa04c4a088ccb7309294b5d4f,
title = "Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA",
abstract = "Autism spectrum disorder (ASD) is characterized by difficulties in social interaction, communication and language, and restricted repertoire of activities and interests. The etiology of ASD remains unknown and no clinical markers for diagnosis were identified. Environmental factors, including prenatal exposure to valproic acid (VPA), may contribute to increased risk of developing ASD. MicroRNA (miRNA) are small noncoding RNA that regulate gene expression and are frequently linked to biological processes affected in neurodevelopmental disorders. In this work, we analyzed the effects of resveratrol (an antioxidant and anti-inflammatory molecule) on behavioral alterations of the VPA model of autism, as well as the levels of circulating miRNA. We also evaluated the same set of miRNA in autistic patients. Rats of the VPA model of autism showed reduced total reciprocal social interaction, prevented by prenatal treatment with resveratrol (RSV). The levels of miR134-5p and miR138-5p increased in autistic patients. Interestingly, miR134-5p is also upregulated in animals of the VPA model, which is prevented by RSV. In conclusion, our findings revealed important preventive actions of RSV in the VPA model, ranging from behavior to molecular alterations. Further evaluation of preventive mechanisms of RSV can shed light in important biomarkers and etiological triggers of ASD.",
keywords = "Adolescent, Animals, Anticonvulsants/toxicity, Antioxidants/pharmacology, Autistic Disorder/chemically induced, Behavior, Animal/drug effects, Child, Child, Preschool, Circulating MicroRNA/blood, Disease Models, Animal, Female, Humans, Male, Maternal Exposure, MicroRNAs/blood, Pregnancy, Prenatal Exposure Delayed Effects, Protein Biosynthesis, Rats, Wistar, Resveratrol, Stilbenes/pharmacology, Valproic Acid/toxicity",
author = "Hirsch, {Mauro Mozael} and Iohanna Deckmann and Mellanie Fontes-Dutra and Guilherme Bauer-Negrini and {Della-Flora Nunes}, Gustavo and Walquiria Nunes and Bruna Rabelo and Rudimar Riesgo and Rogerio Margis and Victorio Bambini-Junior and Carmem Gottfried",
note = "Copyright {\textcopyright} 2018 Elsevier Ltd. All rights reserved.",
year = "2018",
month = may,
day = "31",
doi = "10.1016/j.fct.2018.02.061",
language = "English",
volume = "115",
pages = "336--343",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA

AU - Hirsch, Mauro Mozael

AU - Deckmann, Iohanna

AU - Fontes-Dutra, Mellanie

AU - Bauer-Negrini, Guilherme

AU - Della-Flora Nunes, Gustavo

AU - Nunes, Walquiria

AU - Rabelo, Bruna

AU - Riesgo, Rudimar

AU - Margis, Rogerio

AU - Bambini-Junior, Victorio

AU - Gottfried, Carmem

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/5/31

Y1 - 2018/5/31

N2 - Autism spectrum disorder (ASD) is characterized by difficulties in social interaction, communication and language, and restricted repertoire of activities and interests. The etiology of ASD remains unknown and no clinical markers for diagnosis were identified. Environmental factors, including prenatal exposure to valproic acid (VPA), may contribute to increased risk of developing ASD. MicroRNA (miRNA) are small noncoding RNA that regulate gene expression and are frequently linked to biological processes affected in neurodevelopmental disorders. In this work, we analyzed the effects of resveratrol (an antioxidant and anti-inflammatory molecule) on behavioral alterations of the VPA model of autism, as well as the levels of circulating miRNA. We also evaluated the same set of miRNA in autistic patients. Rats of the VPA model of autism showed reduced total reciprocal social interaction, prevented by prenatal treatment with resveratrol (RSV). The levels of miR134-5p and miR138-5p increased in autistic patients. Interestingly, miR134-5p is also upregulated in animals of the VPA model, which is prevented by RSV. In conclusion, our findings revealed important preventive actions of RSV in the VPA model, ranging from behavior to molecular alterations. Further evaluation of preventive mechanisms of RSV can shed light in important biomarkers and etiological triggers of ASD.

AB - Autism spectrum disorder (ASD) is characterized by difficulties in social interaction, communication and language, and restricted repertoire of activities and interests. The etiology of ASD remains unknown and no clinical markers for diagnosis were identified. Environmental factors, including prenatal exposure to valproic acid (VPA), may contribute to increased risk of developing ASD. MicroRNA (miRNA) are small noncoding RNA that regulate gene expression and are frequently linked to biological processes affected in neurodevelopmental disorders. In this work, we analyzed the effects of resveratrol (an antioxidant and anti-inflammatory molecule) on behavioral alterations of the VPA model of autism, as well as the levels of circulating miRNA. We also evaluated the same set of miRNA in autistic patients. Rats of the VPA model of autism showed reduced total reciprocal social interaction, prevented by prenatal treatment with resveratrol (RSV). The levels of miR134-5p and miR138-5p increased in autistic patients. Interestingly, miR134-5p is also upregulated in animals of the VPA model, which is prevented by RSV. In conclusion, our findings revealed important preventive actions of RSV in the VPA model, ranging from behavior to molecular alterations. Further evaluation of preventive mechanisms of RSV can shed light in important biomarkers and etiological triggers of ASD.

KW - Adolescent

KW - Animals

KW - Anticonvulsants/toxicity

KW - Antioxidants/pharmacology

KW - Autistic Disorder/chemically induced

KW - Behavior, Animal/drug effects

KW - Child

KW - Child, Preschool

KW - Circulating MicroRNA/blood

KW - Disease Models, Animal

KW - Female

KW - Humans

KW - Male

KW - Maternal Exposure

KW - MicroRNAs/blood

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Protein Biosynthesis

KW - Rats, Wistar

KW - Resveratrol

KW - Stilbenes/pharmacology

KW - Valproic Acid/toxicity

U2 - 10.1016/j.fct.2018.02.061

DO - 10.1016/j.fct.2018.02.061

M3 - Journal article

C2 - 29510222

VL - 115

SP - 336

EP - 343

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -