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Beyond the obvious: Environmental health implications of polar polycyclic aromatic hydrocarbons

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Beyond the obvious: Environmental health implications of polar polycyclic aromatic hydrocarbons. / Idowu, O.; Semple, K.T.; Ramadass, K. et al.
In: Environment International, Vol. 123, 02.2019, p. 543-557.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Idowu, O, Semple, KT, Ramadass, K, O'Connor, W, Hansbro, P & Thavamani, P 2019, 'Beyond the obvious: Environmental health implications of polar polycyclic aromatic hydrocarbons', Environment International, vol. 123, pp. 543-557. https://doi.org/10.1016/j.envint.2018.12.051

APA

Idowu, O., Semple, K. T., Ramadass, K., O'Connor, W., Hansbro, P., & Thavamani, P. (2019). Beyond the obvious: Environmental health implications of polar polycyclic aromatic hydrocarbons. Environment International, 123, 543-557. https://doi.org/10.1016/j.envint.2018.12.051

Vancouver

Idowu O, Semple KT, Ramadass K, O'Connor W, Hansbro P, Thavamani P. Beyond the obvious: Environmental health implications of polar polycyclic aromatic hydrocarbons. Environment International. 2019 Feb;123:543-557. Epub 2019 Jan 5. doi: 10.1016/j.envint.2018.12.051

Author

Idowu, O. ; Semple, K.T. ; Ramadass, K. et al. / Beyond the obvious : Environmental health implications of polar polycyclic aromatic hydrocarbons. In: Environment International. 2019 ; Vol. 123. pp. 543-557.

Bibtex

@article{f3822bc73d614d6298a63eac215b3b8c,
title = "Beyond the obvious: Environmental health implications of polar polycyclic aromatic hydrocarbons",
abstract = "The genotoxic, mutagenic and carcinogenic effects of polar polycyclic aromatic hydrocarbons (polar PAHs) are believed to surpass those of their parent PAHs; however, their environmental and human health implications have been largely unexplored. Oxygenated PAHs (oxy-PAHs) is a critical class of polar PAHs associated with carcinogenic effects without enzymatic activation. They also cause an upsurge in reactive oxygen species (ROS) in living cells. This results in oxidative stress and other consequences, such as abnormal gene expressions, altered protein activities, mutagenesis, and carcinogenesis. Similarly, some nitrated PAHs (N-PAHs) are probable human carcinogens as classified by the International Agency for Research on Cancer (IARC). Heterocyclic PAHs (polar PAHs containing nitrogen, sulphur and oxygen atoms within the aromatic rings) have been shown to be potent endocrine disruptors, primarily through their estrogenic activities. Despite the high toxicity and enhanced environmental mobility of many polar PAHs, they have attracted only a little attention in risk assessment of contaminated sites. This may lead to underestimation of potential risks, and remediation end points. In this review, the toxicity of polar PAHs and their associated mechanisms of action, including their role in mutagenic, carcinogenic, developmental and teratogenic effects are critically discussed. This review suggests that polar PAHs could have serious toxicological effects on human health and should be considered during risk assessment of PAH-contaminated sites. The implications of not doing so were argued and critical knowledge gaps and future research requirements discussed. {\textcopyright} 2018",
keywords = "Carcinogenesis, Environmental health, Human health, Mutagenesis, Polar polycyclic aromatic hydrocarbons, Aromatization, Environmental engineering, Gene expression, Health risks, Hydrocarbons, International cooperation, Mineral oils, Oxygen, Pathology, Risk assessment, Toxicity, Environmental mobility, Estrogenic activities, International agency for research on cancers, Reactive oxygen species, Toxicological effects, Polycyclic aromatic hydrocarbons, aromatic hydrocarbon receptor, heterocyclic compound, heterocyclic polycyclic aromatic hydrocarbon, homocyclic polycyclic aromatic hydrocarbon, nitrated polycyclic aromatic hydrocarbon, nitrogen, oxygen, oxygenated polycyclic aromatic hydrocarbon, polar polycyclic aromatic hydrocarbon, polycyclic aromatic hydrocarbon, sulfur, unclassified drug, water, ecosystem health, endocrine disruptor, gene expression, mutagenicity, oxidative stress, PAH, public health, reactive oxygen species, air, carcinogenic activity, carcinogenicity, chemical composition, developmental toxicity, ecosystem restoration, environmental exposure, environmental health, environmental impact, genotoxicity, mutagenic activity, physical chemistry, priority journal, Review, risk assessment, soil, teratogenicity",
author = "O. Idowu and K.T. Semple and K. Ramadass and W. O'Connor and P. Hansbro and P. Thavamani",
year = "2019",
month = feb,
doi = "10.1016/j.envint.2018.12.051",
language = "English",
volume = "123",
pages = "543--557",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Beyond the obvious

T2 - Environmental health implications of polar polycyclic aromatic hydrocarbons

AU - Idowu, O.

AU - Semple, K.T.

AU - Ramadass, K.

AU - O'Connor, W.

AU - Hansbro, P.

AU - Thavamani, P.

PY - 2019/2

Y1 - 2019/2

N2 - The genotoxic, mutagenic and carcinogenic effects of polar polycyclic aromatic hydrocarbons (polar PAHs) are believed to surpass those of their parent PAHs; however, their environmental and human health implications have been largely unexplored. Oxygenated PAHs (oxy-PAHs) is a critical class of polar PAHs associated with carcinogenic effects without enzymatic activation. They also cause an upsurge in reactive oxygen species (ROS) in living cells. This results in oxidative stress and other consequences, such as abnormal gene expressions, altered protein activities, mutagenesis, and carcinogenesis. Similarly, some nitrated PAHs (N-PAHs) are probable human carcinogens as classified by the International Agency for Research on Cancer (IARC). Heterocyclic PAHs (polar PAHs containing nitrogen, sulphur and oxygen atoms within the aromatic rings) have been shown to be potent endocrine disruptors, primarily through their estrogenic activities. Despite the high toxicity and enhanced environmental mobility of many polar PAHs, they have attracted only a little attention in risk assessment of contaminated sites. This may lead to underestimation of potential risks, and remediation end points. In this review, the toxicity of polar PAHs and their associated mechanisms of action, including their role in mutagenic, carcinogenic, developmental and teratogenic effects are critically discussed. This review suggests that polar PAHs could have serious toxicological effects on human health and should be considered during risk assessment of PAH-contaminated sites. The implications of not doing so were argued and critical knowledge gaps and future research requirements discussed. © 2018

AB - The genotoxic, mutagenic and carcinogenic effects of polar polycyclic aromatic hydrocarbons (polar PAHs) are believed to surpass those of their parent PAHs; however, their environmental and human health implications have been largely unexplored. Oxygenated PAHs (oxy-PAHs) is a critical class of polar PAHs associated with carcinogenic effects without enzymatic activation. They also cause an upsurge in reactive oxygen species (ROS) in living cells. This results in oxidative stress and other consequences, such as abnormal gene expressions, altered protein activities, mutagenesis, and carcinogenesis. Similarly, some nitrated PAHs (N-PAHs) are probable human carcinogens as classified by the International Agency for Research on Cancer (IARC). Heterocyclic PAHs (polar PAHs containing nitrogen, sulphur and oxygen atoms within the aromatic rings) have been shown to be potent endocrine disruptors, primarily through their estrogenic activities. Despite the high toxicity and enhanced environmental mobility of many polar PAHs, they have attracted only a little attention in risk assessment of contaminated sites. This may lead to underestimation of potential risks, and remediation end points. In this review, the toxicity of polar PAHs and their associated mechanisms of action, including their role in mutagenic, carcinogenic, developmental and teratogenic effects are critically discussed. This review suggests that polar PAHs could have serious toxicological effects on human health and should be considered during risk assessment of PAH-contaminated sites. The implications of not doing so were argued and critical knowledge gaps and future research requirements discussed. © 2018

KW - Carcinogenesis

KW - Environmental health

KW - Human health

KW - Mutagenesis

KW - Polar polycyclic aromatic hydrocarbons

KW - Aromatization

KW - Environmental engineering

KW - Gene expression

KW - Health risks

KW - Hydrocarbons

KW - International cooperation

KW - Mineral oils

KW - Oxygen

KW - Pathology

KW - Risk assessment

KW - Toxicity

KW - Environmental mobility

KW - Estrogenic activities

KW - International agency for research on cancers

KW - Reactive oxygen species

KW - Toxicological effects

KW - Polycyclic aromatic hydrocarbons

KW - aromatic hydrocarbon receptor

KW - heterocyclic compound

KW - heterocyclic polycyclic aromatic hydrocarbon

KW - homocyclic polycyclic aromatic hydrocarbon

KW - nitrated polycyclic aromatic hydrocarbon

KW - nitrogen

KW - oxygen

KW - oxygenated polycyclic aromatic hydrocarbon

KW - polar polycyclic aromatic hydrocarbon

KW - polycyclic aromatic hydrocarbon

KW - sulfur

KW - unclassified drug

KW - water

KW - ecosystem health

KW - endocrine disruptor

KW - gene expression

KW - mutagenicity

KW - oxidative stress

KW - PAH

KW - public health

KW - reactive oxygen species

KW - air

KW - carcinogenic activity

KW - carcinogenicity

KW - chemical composition

KW - developmental toxicity

KW - ecosystem restoration

KW - environmental exposure

KW - environmental health

KW - environmental impact

KW - genotoxicity

KW - mutagenic activity

KW - physical chemistry

KW - priority journal

KW - Review

KW - risk assessment

KW - soil

KW - teratogenicity

U2 - 10.1016/j.envint.2018.12.051

DO - 10.1016/j.envint.2018.12.051

M3 - Journal article

VL - 123

SP - 543

EP - 557

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -