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Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain. / Pliatsikas, Christos; Pereira Soares, S. M.; Voits, T. et al.
In: Scientific Reports, Vol. 11, No. 1, 7090, 31.12.2021.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Pliatsikas, C, Pereira Soares, SM, Voits, T, Deluca, V & Rothman, J 2021, 'Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain', Scientific Reports, vol. 11, no. 1, 7090. https://doi.org/10.1038/s41598-021-86443-4

APA

Pliatsikas, C., Pereira Soares, S. M., Voits, T., Deluca, V., & Rothman, J. (2021). Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain. Scientific Reports, 11(1), Article 7090. https://doi.org/10.1038/s41598-021-86443-4

Vancouver

Pliatsikas C, Pereira Soares SM, Voits T, Deluca V, Rothman J. Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain. Scientific Reports. 2021 Dec 31;11(1):7090. Epub 2021 Mar 29. doi: 10.1038/s41598-021-86443-4

Author

Pliatsikas, Christos ; Pereira Soares, S. M. ; Voits, T. et al. / Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain. In: Scientific Reports. 2021 ; Vol. 11, No. 1.

Bibtex

@article{19a929d1a7ff4dc5b9cc4fa85252fbc0,
title = "Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain",
abstract = "Cognitively demanding experiences, including complex skill acquisition and processing, have been shown to induce brain adaptations, at least at the macroscopic level, e.g. on brain volume and/or functional connectivity. However, the neurobiological bases of these adaptations, including at the cellular level, are unclear and understudied. Here we use bilingualism as a case study to investigate the metabolic correlates of experience-based brain adaptations. We employ Magnetic Resonance Spectroscopy to measure metabolite concentrations in the basal ganglia, a region critical to language control which is reshaped by bilingualism. Our results show increased myo-Inositol and decreased N-acetyl aspartate concentrations in bilinguals compared to monolinguals. Both metabolites are linked to synaptic pruning, a process underlying experience-based brain restructuring. Interestingly, both concentrations correlate with relative amount of bilingual engagement. This suggests that degree of long-term cognitive experiences matters at the level of metabolic concentrations, which might accompany, if not drive, macroscopic brain adaptations.",
author = "Christos Pliatsikas and {Pereira Soares}, {S. M.} and T. Voits and V. Deluca and J. Rothman",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
day = "31",
doi = "10.1038/s41598-021-86443-4",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain

AU - Pliatsikas, Christos

AU - Pereira Soares, S. M.

AU - Voits, T.

AU - Deluca, V.

AU - Rothman, J.

N1 - Publisher Copyright: © 2021, The Author(s).

PY - 2021/12/31

Y1 - 2021/12/31

N2 - Cognitively demanding experiences, including complex skill acquisition and processing, have been shown to induce brain adaptations, at least at the macroscopic level, e.g. on brain volume and/or functional connectivity. However, the neurobiological bases of these adaptations, including at the cellular level, are unclear and understudied. Here we use bilingualism as a case study to investigate the metabolic correlates of experience-based brain adaptations. We employ Magnetic Resonance Spectroscopy to measure metabolite concentrations in the basal ganglia, a region critical to language control which is reshaped by bilingualism. Our results show increased myo-Inositol and decreased N-acetyl aspartate concentrations in bilinguals compared to monolinguals. Both metabolites are linked to synaptic pruning, a process underlying experience-based brain restructuring. Interestingly, both concentrations correlate with relative amount of bilingual engagement. This suggests that degree of long-term cognitive experiences matters at the level of metabolic concentrations, which might accompany, if not drive, macroscopic brain adaptations.

AB - Cognitively demanding experiences, including complex skill acquisition and processing, have been shown to induce brain adaptations, at least at the macroscopic level, e.g. on brain volume and/or functional connectivity. However, the neurobiological bases of these adaptations, including at the cellular level, are unclear and understudied. Here we use bilingualism as a case study to investigate the metabolic correlates of experience-based brain adaptations. We employ Magnetic Resonance Spectroscopy to measure metabolite concentrations in the basal ganglia, a region critical to language control which is reshaped by bilingualism. Our results show increased myo-Inositol and decreased N-acetyl aspartate concentrations in bilinguals compared to monolinguals. Both metabolites are linked to synaptic pruning, a process underlying experience-based brain restructuring. Interestingly, both concentrations correlate with relative amount of bilingual engagement. This suggests that degree of long-term cognitive experiences matters at the level of metabolic concentrations, which might accompany, if not drive, macroscopic brain adaptations.

U2 - 10.1038/s41598-021-86443-4

DO - 10.1038/s41598-021-86443-4

M3 - Journal article

C2 - 33782462

AN - SCOPUS:85103558454

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 7090

ER -