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Binding of waterborne pharmaceutical and personal care products to natural dissolved organic matter

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Binding of waterborne pharmaceutical and personal care products to natural dissolved organic matter. / Rizzuto, S.; Baho, D.L.; Jones, K.C. et al.

In: Science of the Total Environment, Vol. 784, 147208, 25.08.2021.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Rizzuto S, Baho DL, Jones KC, Zhang H, Leu E, Nizzetto L. Binding of waterborne pharmaceutical and personal care products to natural dissolved organic matter. Science of the Total Environment. 2021 Aug 25;784:147208. Epub 2021 Apr 20. doi: 10.1016/j.scitotenv.2021.147208

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Bibtex

@article{06e966c913ef4c8f84d673dbfc7b7ae8,
title = "Binding of waterborne pharmaceutical and personal care products to natural dissolved organic matter",
abstract = "Information on how key environmental conditions such as natural dissolved organic matter (DOM) and water pH alter the possible risks posed by pharmaceuticals (PPCPs) is still scarce. In our previous study, the presence of natural DOM at high pH reduced the toxicity of a mix of waterborne PPCPs to algae. DOM-complexation and pH effect on speciation of the more hydrophobic and neutral compounds of the mix was suggested to be driving this behaviour. However, the study design did not allow the verification of this hypothesis. Here, the DOM- PPCPs interaction at different pH was investigated for 6 PPCPs through equilibrium dialysis, under the same conditions of DOM and pH as our previous study. Association with DOM was confirmed for the more hydrophobic PPCPs at high pH. The results suggest the binding was driven by i) the presence of carboxylic groups of PPCPs, ii) high pH shifting the structural configuration of DOM, making it more suited to bind some of the PPCPs. A non-linear change of binding capacity with increasing DOM concentration was also observed among the tested PPCPs. ",
keywords = "Binding, Natural dissolved organic matter, Pharmaceuticals and personal care products, Water chemistry, Biogeochemistry, Biological materials, Hydrophobicity, Organic compounds, pH effects, Dissolved organic matters, Environmental conditions, High pH, Hydrophobic compounds, Neutral compounds, Organic waters, Pharmaceutical and personal care products, Dissolution",
author = "S. Rizzuto and D.L. Baho and K.C. Jones and H. Zhang and E. Leu and L. Nizzetto",
year = "2021",
month = aug,
day = "25",
doi = "10.1016/j.scitotenv.2021.147208",
language = "English",
volume = "784",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier Science B.V.",

}

RIS

TY - JOUR

T1 - Binding of waterborne pharmaceutical and personal care products to natural dissolved organic matter

AU - Rizzuto, S.

AU - Baho, D.L.

AU - Jones, K.C.

AU - Zhang, H.

AU - Leu, E.

AU - Nizzetto, L.

PY - 2021/8/25

Y1 - 2021/8/25

N2 - Information on how key environmental conditions such as natural dissolved organic matter (DOM) and water pH alter the possible risks posed by pharmaceuticals (PPCPs) is still scarce. In our previous study, the presence of natural DOM at high pH reduced the toxicity of a mix of waterborne PPCPs to algae. DOM-complexation and pH effect on speciation of the more hydrophobic and neutral compounds of the mix was suggested to be driving this behaviour. However, the study design did not allow the verification of this hypothesis. Here, the DOM- PPCPs interaction at different pH was investigated for 6 PPCPs through equilibrium dialysis, under the same conditions of DOM and pH as our previous study. Association with DOM was confirmed for the more hydrophobic PPCPs at high pH. The results suggest the binding was driven by i) the presence of carboxylic groups of PPCPs, ii) high pH shifting the structural configuration of DOM, making it more suited to bind some of the PPCPs. A non-linear change of binding capacity with increasing DOM concentration was also observed among the tested PPCPs.

AB - Information on how key environmental conditions such as natural dissolved organic matter (DOM) and water pH alter the possible risks posed by pharmaceuticals (PPCPs) is still scarce. In our previous study, the presence of natural DOM at high pH reduced the toxicity of a mix of waterborne PPCPs to algae. DOM-complexation and pH effect on speciation of the more hydrophobic and neutral compounds of the mix was suggested to be driving this behaviour. However, the study design did not allow the verification of this hypothesis. Here, the DOM- PPCPs interaction at different pH was investigated for 6 PPCPs through equilibrium dialysis, under the same conditions of DOM and pH as our previous study. Association with DOM was confirmed for the more hydrophobic PPCPs at high pH. The results suggest the binding was driven by i) the presence of carboxylic groups of PPCPs, ii) high pH shifting the structural configuration of DOM, making it more suited to bind some of the PPCPs. A non-linear change of binding capacity with increasing DOM concentration was also observed among the tested PPCPs.

KW - Binding

KW - Natural dissolved organic matter

KW - Pharmaceuticals and personal care products

KW - Water chemistry

KW - Biogeochemistry

KW - Biological materials

KW - Hydrophobicity

KW - Organic compounds

KW - pH effects

KW - Dissolved organic matters

KW - Environmental conditions

KW - High pH

KW - Hydrophobic compounds

KW - Neutral compounds

KW - Organic waters

KW - Pharmaceutical and personal care products

KW - Dissolution

U2 - 10.1016/j.scitotenv.2021.147208

DO - 10.1016/j.scitotenv.2021.147208

M3 - Journal article

VL - 784

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

M1 - 147208

ER -