Home > Research > Publications & Outputs > BINOL-3,3′-trifloneN,N-dimethyl phosphoramidite...

Text available via DOI:

View graph of relations

BINOL-3,3′-trifloneN,N-dimethyl phosphoramidites: Through-space 19F,31P spin-spin coupling with a remarkable dependency on temperature and solvent internal pressure

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

BINOL-3,3′-trifloneN,N-dimethyl phosphoramidites: Through-space 19F,31P spin-spin coupling with a remarkable dependency on temperature and solvent internal pressure. / Kruck, Matthias; Munoz-Herranz, Maria; Bishop, Hannah L. et al.
In: Chemistry - A European Journal, Vol. 14, No. 26, 01.09.2008, p. 7808-7812.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Kruck, M, Munoz-Herranz, M, Bishop, HL, Frost, CG, Chapman, CJ, Kociok-Köhn, G, Butts, CP & Lloyd-Jones, GC 2008, 'BINOL-3,3′-trifloneN,N-dimethyl phosphoramidites: Through-space 19F,31P spin-spin coupling with a remarkable dependency on temperature and solvent internal pressure', Chemistry - A European Journal, vol. 14, no. 26, pp. 7808-7812. https://doi.org/10.1002/chem.200800825

APA

Kruck, M., Munoz-Herranz, M., Bishop, H. L., Frost, C. G., Chapman, C. J., Kociok-Köhn, G., Butts, C. P., & Lloyd-Jones, G. C. (2008). BINOL-3,3′-trifloneN,N-dimethyl phosphoramidites: Through-space 19F,31P spin-spin coupling with a remarkable dependency on temperature and solvent internal pressure. Chemistry - A European Journal, 14(26), 7808-7812. https://doi.org/10.1002/chem.200800825

Vancouver

Kruck M, Munoz-Herranz M, Bishop HL, Frost CG, Chapman CJ, Kociok-Köhn G et al. BINOL-3,3′-trifloneN,N-dimethyl phosphoramidites: Through-space 19F,31P spin-spin coupling with a remarkable dependency on temperature and solvent internal pressure. Chemistry - A European Journal. 2008 Sept 1;14(26):7808-7812. doi: 10.1002/chem.200800825

Author

Bibtex

@article{54e485916f2e4fefa3f002b31a9ed7f1,
title = "BINOL-3,3′-trifloneN,N-dimethyl phosphoramidites: Through-space 19F,31P spin-spin coupling with a remarkable dependency on temperature and solvent internal pressure",
abstract = "A combined computational and experimental study of the effects of solvent, temperature and stereochemistry on the magnitude of the through-space spin–spin coupling between 31P and 19F nuclei which are six-bonds apart is described. The reaction of 3-trifluoromethylsulfonyl-2,'2-dihydroxy-1,1'-binaphthalene (3-SO2CF3-BINOL) with hexamethylphosphorous triamide (P(NMe2)3) generates a pair of N,N-dimethylphosphoramidites which are diastereomeric due to their differing relative configurations at the stereogenic phosphorous centre and the axially chiral (atropisomeric) BINOL unit. Through-space NMR coupling of the 31P and 19F nuclei of the phosphoramidite and sulfone is detected in one diastereomer only. In the analogous N,N-dimethylphosphoramidite generated from 3,3'-(SO2CF3)2-BINOL only one of the diastereotopic trifluoromethylsulfone moieties couples with the 31P of the phosphoramidite. In both cases, the magnitude of the coupling is strongly modulated (up to 400?%) by solvent and temperature. A detailed DFT analysis of the response of the coupling to the orientation of the CF3 moiety with respect to the P-lone pair facilitates a confident assignment of the stereochemical identity of the pair of diastereomers. The analysis shows that the intriguing effects of environment on the magnitude of the coupling can be rationalised by a complex interplay of solvent internal pressure, molecular volume and thermal access to a wider conformational space. These phenomena suggest the possibility for the design of sensitive molecular probes for local environment that can be addressed via through-space NMR coupling.",
author = "Matthias Kruck and Maria Munoz-Herranz and Bishop, {Hannah L.} and Frost, {Christopher G.} and Chapman, {Christopher J.} and Gabriele Kociok-K{\"o}hn and Butts, {Craig P.} and Lloyd-Jones, {Guy C.}",
year = "2008",
month = sep,
day = "1",
doi = "10.1002/chem.200800825",
language = "English",
volume = "14",
pages = "7808--7812",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "26",

}

RIS

TY - JOUR

T1 - BINOL-3,3′-trifloneN,N-dimethyl phosphoramidites: Through-space 19F,31P spin-spin coupling with a remarkable dependency on temperature and solvent internal pressure

AU - Kruck, Matthias

AU - Munoz-Herranz, Maria

AU - Bishop, Hannah L.

AU - Frost, Christopher G.

AU - Chapman, Christopher J.

AU - Kociok-Köhn, Gabriele

AU - Butts, Craig P.

AU - Lloyd-Jones, Guy C.

PY - 2008/9/1

Y1 - 2008/9/1

N2 - A combined computational and experimental study of the effects of solvent, temperature and stereochemistry on the magnitude of the through-space spin–spin coupling between 31P and 19F nuclei which are six-bonds apart is described. The reaction of 3-trifluoromethylsulfonyl-2,'2-dihydroxy-1,1'-binaphthalene (3-SO2CF3-BINOL) with hexamethylphosphorous triamide (P(NMe2)3) generates a pair of N,N-dimethylphosphoramidites which are diastereomeric due to their differing relative configurations at the stereogenic phosphorous centre and the axially chiral (atropisomeric) BINOL unit. Through-space NMR coupling of the 31P and 19F nuclei of the phosphoramidite and sulfone is detected in one diastereomer only. In the analogous N,N-dimethylphosphoramidite generated from 3,3'-(SO2CF3)2-BINOL only one of the diastereotopic trifluoromethylsulfone moieties couples with the 31P of the phosphoramidite. In both cases, the magnitude of the coupling is strongly modulated (up to 400?%) by solvent and temperature. A detailed DFT analysis of the response of the coupling to the orientation of the CF3 moiety with respect to the P-lone pair facilitates a confident assignment of the stereochemical identity of the pair of diastereomers. The analysis shows that the intriguing effects of environment on the magnitude of the coupling can be rationalised by a complex interplay of solvent internal pressure, molecular volume and thermal access to a wider conformational space. These phenomena suggest the possibility for the design of sensitive molecular probes for local environment that can be addressed via through-space NMR coupling.

AB - A combined computational and experimental study of the effects of solvent, temperature and stereochemistry on the magnitude of the through-space spin–spin coupling between 31P and 19F nuclei which are six-bonds apart is described. The reaction of 3-trifluoromethylsulfonyl-2,'2-dihydroxy-1,1'-binaphthalene (3-SO2CF3-BINOL) with hexamethylphosphorous triamide (P(NMe2)3) generates a pair of N,N-dimethylphosphoramidites which are diastereomeric due to their differing relative configurations at the stereogenic phosphorous centre and the axially chiral (atropisomeric) BINOL unit. Through-space NMR coupling of the 31P and 19F nuclei of the phosphoramidite and sulfone is detected in one diastereomer only. In the analogous N,N-dimethylphosphoramidite generated from 3,3'-(SO2CF3)2-BINOL only one of the diastereotopic trifluoromethylsulfone moieties couples with the 31P of the phosphoramidite. In both cases, the magnitude of the coupling is strongly modulated (up to 400?%) by solvent and temperature. A detailed DFT analysis of the response of the coupling to the orientation of the CF3 moiety with respect to the P-lone pair facilitates a confident assignment of the stereochemical identity of the pair of diastereomers. The analysis shows that the intriguing effects of environment on the magnitude of the coupling can be rationalised by a complex interplay of solvent internal pressure, molecular volume and thermal access to a wider conformational space. These phenomena suggest the possibility for the design of sensitive molecular probes for local environment that can be addressed via through-space NMR coupling.

U2 - 10.1002/chem.200800825

DO - 10.1002/chem.200800825

M3 - Journal article

VL - 14

SP - 7808

EP - 7812

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 26

ER -