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Biodegradable electroactive polymers for electrochemically-triggered drug delivery

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Biodegradable electroactive polymers for electrochemically-triggered drug delivery. / Hardy, John G.; Mouser, David J.; Arroyo-Currás, Netzahualcóyotl; Geissler, Sydney; Chow, Jacqueline K.; Nguy, Lindsey; Kim, Jong M.; Schmidt, Christine E.

In: Journal of Materials Chemistry B, Vol. 2, No. 39, 21.10.2014, p. 6809-6822.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hardy, JG, Mouser, DJ, Arroyo-Currás, N, Geissler, S, Chow, JK, Nguy, L, Kim, JM & Schmidt, CE 2014, 'Biodegradable electroactive polymers for electrochemically-triggered drug delivery', Journal of Materials Chemistry B, vol. 2, no. 39, pp. 6809-6822. https://doi.org/10.1039/C4TB00355A

APA

Hardy, J. G., Mouser, D. J., Arroyo-Currás, N., Geissler, S., Chow, J. K., Nguy, L., Kim, J. M., & Schmidt, C. E. (2014). Biodegradable electroactive polymers for electrochemically-triggered drug delivery. Journal of Materials Chemistry B, 2(39), 6809-6822. https://doi.org/10.1039/C4TB00355A

Vancouver

Hardy JG, Mouser DJ, Arroyo-Currás N, Geissler S, Chow JK, Nguy L et al. Biodegradable electroactive polymers for electrochemically-triggered drug delivery. Journal of Materials Chemistry B. 2014 Oct 21;2(39):6809-6822. https://doi.org/10.1039/C4TB00355A

Author

Hardy, John G. ; Mouser, David J. ; Arroyo-Currás, Netzahualcóyotl ; Geissler, Sydney ; Chow, Jacqueline K. ; Nguy, Lindsey ; Kim, Jong M. ; Schmidt, Christine E. / Biodegradable electroactive polymers for electrochemically-triggered drug delivery. In: Journal of Materials Chemistry B. 2014 ; Vol. 2, No. 39. pp. 6809-6822.

Bibtex

@article{ffd42a8762bc4fb49a393cb1f20f0954,
title = "Biodegradable electroactive polymers for electrochemically-triggered drug delivery",
abstract = "We report biodegradable electroactive polymer (EAP)-based materials and their application as drug delivery devices. Copolymers composed of oligoaniline-based electroactive blocks linked to either polyethylene glycol or polycaprolactone blocks via ester bonds were synthesized in three steps from commercially available starting materials and isolated without the need for column chromatography. The physicochemical and electrochemical properties of the polymers were characterized with a variety of techniques. The ability of the polymers to deliver the anti-inflammatory drug dexamethasone phosphate on the application of electrochemical stimuli was studied spectroscopically. Films of the polymers were shown to be degradable and cell adhesive in vitro. Such EAP-based materials have prospects for integration in implantable fully biodegradable/bioerodible EAP-based drug delivery devices that are capable of controlling the chronopharmacology of drugs for future clinical application.",
keywords = "electroactive polymers, conducting polymers, drug delivery, biomaterials, biodegradable polymers, Biomaterials, Chemistry(all), Medicine(all)",
author = "Hardy, {John G.} and Mouser, {David J.} and Netzahualc{\'o}yotl Arroyo-Curr{\'a}s and Sydney Geissler and Chow, {Jacqueline K.} and Lindsey Nguy and Kim, {Jong M.} and Schmidt, {Christine E.}",
year = "2014",
month = oct,
day = "21",
doi = "10.1039/C4TB00355A",
language = "English",
volume = "2",
pages = "6809--6822",
journal = "Journal of Materials Chemistry B",
issn = "2050-750X",
publisher = "Royal Society of Chemistry",
number = "39",

}

RIS

TY - JOUR

T1 - Biodegradable electroactive polymers for electrochemically-triggered drug delivery

AU - Hardy, John G.

AU - Mouser, David J.

AU - Arroyo-Currás, Netzahualcóyotl

AU - Geissler, Sydney

AU - Chow, Jacqueline K.

AU - Nguy, Lindsey

AU - Kim, Jong M.

AU - Schmidt, Christine E.

PY - 2014/10/21

Y1 - 2014/10/21

N2 - We report biodegradable electroactive polymer (EAP)-based materials and their application as drug delivery devices. Copolymers composed of oligoaniline-based electroactive blocks linked to either polyethylene glycol or polycaprolactone blocks via ester bonds were synthesized in three steps from commercially available starting materials and isolated without the need for column chromatography. The physicochemical and electrochemical properties of the polymers were characterized with a variety of techniques. The ability of the polymers to deliver the anti-inflammatory drug dexamethasone phosphate on the application of electrochemical stimuli was studied spectroscopically. Films of the polymers were shown to be degradable and cell adhesive in vitro. Such EAP-based materials have prospects for integration in implantable fully biodegradable/bioerodible EAP-based drug delivery devices that are capable of controlling the chronopharmacology of drugs for future clinical application.

AB - We report biodegradable electroactive polymer (EAP)-based materials and their application as drug delivery devices. Copolymers composed of oligoaniline-based electroactive blocks linked to either polyethylene glycol or polycaprolactone blocks via ester bonds were synthesized in three steps from commercially available starting materials and isolated without the need for column chromatography. The physicochemical and electrochemical properties of the polymers were characterized with a variety of techniques. The ability of the polymers to deliver the anti-inflammatory drug dexamethasone phosphate on the application of electrochemical stimuli was studied spectroscopically. Films of the polymers were shown to be degradable and cell adhesive in vitro. Such EAP-based materials have prospects for integration in implantable fully biodegradable/bioerodible EAP-based drug delivery devices that are capable of controlling the chronopharmacology of drugs for future clinical application.

KW - electroactive polymers

KW - conducting polymers

KW - drug delivery

KW - biomaterials

KW - biodegradable polymers

KW - Biomaterials

KW - Chemistry(all)

KW - Medicine(all)

U2 - 10.1039/C4TB00355A

DO - 10.1039/C4TB00355A

M3 - Journal article

VL - 2

SP - 6809

EP - 6822

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-750X

IS - 39

ER -