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Biodegradable hydrogels composed of oxime cross-linked poly(ethylene glycol), hyaluronic acid and collagen: a platform for soft tissue engineering

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Biodegradable hydrogels composed of oxime cross-linked poly(ethylene glycol), hyaluronic acid and collagen : a platform for soft tissue engineering. / Hardy, John George; Lin, Phillip; Schmidt, Christine E.

In: Journal of Biomaterials Science, Polymer Edition, Vol. 26, No. 3, 2015, p. 143-161.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Hardy JG, Lin P, Schmidt CE. Biodegradable hydrogels composed of oxime cross-linked poly(ethylene glycol), hyaluronic acid and collagen: a platform for soft tissue engineering. Journal of Biomaterials Science, Polymer Edition. 2015;26(3):143-161. Epub 2015 Jan 2. doi: 10.1080/09205063.2014.975393

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Hardy, John George ; Lin, Phillip ; Schmidt, Christine E. / Biodegradable hydrogels composed of oxime cross-linked poly(ethylene glycol), hyaluronic acid and collagen : a platform for soft tissue engineering. In: Journal of Biomaterials Science, Polymer Edition. 2015 ; Vol. 26, No. 3. pp. 143-161.

Bibtex

@article{102631eb146942a6a59b83fc7b19cf2e,
title = "Biodegradable hydrogels composed of oxime cross-linked poly(ethylene glycol), hyaluronic acid and collagen: a platform for soft tissue engineering",
abstract = "In situ crosslinking hydrogels are attractive for application as injectable hydrogel-based tissue scaffolds that adapt to fill patient-specific cavities. Oxime click chemistry was used to crosslink hydrogels that were biodegradable, soft, and supportive of cell adhesion. Linear poly(ethylene glycol)s (PEGs, Mn 2 or 4 kDa) terminated at both ends with aminooxy moieties and hyaluronic acid (HA, Mn 2 MDa) derivatives displaying aldehydes were non-toxic towards primary Schwann cells. The PEG and HA derivatives form oxime crosslinked hydrogels with mechanical and swelling properties that were tunable based on the composition of the hydrogels to values analogous to soft tissues such as those found in the central or peripheral nervous system. Gels incorporating collagen-1 supported the adhesion of human mesenchymal stem cells (HMSCs). Such chemistry has the potential to generate clinically relevant injectable hydrogels for minimally invasive personalized medical procedures in the central or peripheral nervous systems.",
keywords = "peripheral nervous system, tissue engineering, injectable hydrogels, in vitro cell culture, biodegradable biomaterials, central nervous system, biomimetic mechanical properties, Chemistry(all), Biomaterials",
author = "Hardy, {John George} and Phillip Lin and Schmidt, {Christine E.}",
year = "2015",
doi = "10.1080/09205063.2014.975393",
language = "English",
volume = "26",
pages = "143--161",
journal = "Journal of Biomaterials Science, Polymer Edition",
issn = "0920-5063",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Biodegradable hydrogels composed of oxime cross-linked poly(ethylene glycol), hyaluronic acid and collagen

T2 - a platform for soft tissue engineering

AU - Hardy, John George

AU - Lin, Phillip

AU - Schmidt, Christine E.

PY - 2015

Y1 - 2015

N2 - In situ crosslinking hydrogels are attractive for application as injectable hydrogel-based tissue scaffolds that adapt to fill patient-specific cavities. Oxime click chemistry was used to crosslink hydrogels that were biodegradable, soft, and supportive of cell adhesion. Linear poly(ethylene glycol)s (PEGs, Mn 2 or 4 kDa) terminated at both ends with aminooxy moieties and hyaluronic acid (HA, Mn 2 MDa) derivatives displaying aldehydes were non-toxic towards primary Schwann cells. The PEG and HA derivatives form oxime crosslinked hydrogels with mechanical and swelling properties that were tunable based on the composition of the hydrogels to values analogous to soft tissues such as those found in the central or peripheral nervous system. Gels incorporating collagen-1 supported the adhesion of human mesenchymal stem cells (HMSCs). Such chemistry has the potential to generate clinically relevant injectable hydrogels for minimally invasive personalized medical procedures in the central or peripheral nervous systems.

AB - In situ crosslinking hydrogels are attractive for application as injectable hydrogel-based tissue scaffolds that adapt to fill patient-specific cavities. Oxime click chemistry was used to crosslink hydrogels that were biodegradable, soft, and supportive of cell adhesion. Linear poly(ethylene glycol)s (PEGs, Mn 2 or 4 kDa) terminated at both ends with aminooxy moieties and hyaluronic acid (HA, Mn 2 MDa) derivatives displaying aldehydes were non-toxic towards primary Schwann cells. The PEG and HA derivatives form oxime crosslinked hydrogels with mechanical and swelling properties that were tunable based on the composition of the hydrogels to values analogous to soft tissues such as those found in the central or peripheral nervous system. Gels incorporating collagen-1 supported the adhesion of human mesenchymal stem cells (HMSCs). Such chemistry has the potential to generate clinically relevant injectable hydrogels for minimally invasive personalized medical procedures in the central or peripheral nervous systems.

KW - peripheral nervous system

KW - tissue engineering

KW - injectable hydrogels

KW - in vitro cell culture

KW - biodegradable biomaterials

KW - central nervous system

KW - biomimetic mechanical properties

KW - Chemistry(all)

KW - Biomaterials

U2 - 10.1080/09205063.2014.975393

DO - 10.1080/09205063.2014.975393

M3 - Journal article

VL - 26

SP - 143

EP - 161

JO - Journal of Biomaterials Science, Polymer Edition

JF - Journal of Biomaterials Science, Polymer Edition

SN - 0920-5063

IS - 3

ER -