Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Biodegradable polyurethanes : biodegradable low adherence films for the prevention of adhesions after surgery. / Rehman, I.U.
In: JOURNAL OF BIOMATERIALS APPLICATIONS, Vol. 11, No. 2, 1996, p. 182-257.Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Biodegradable polyurethanes
T2 - biodegradable low adherence films for the prevention of adhesions after surgery
AU - Rehman, I.U.
PY - 1996
Y1 - 1996
N2 - Adhesions commonly occur after internal disease or surgery. The natural healing response leads to the formation of vascular and avascular adhesions after inflammatory diseases and surgical interventions. A barrier film could be incorporated during surgery between layers of tissues that must not adhere to one another. The film would be biodegradable so that it disappears over a period of time, and would ideally be two sided, allowing relative movement at that interface, while being firmly anchored on the opposite side to prevent displacement. Polyesterurethane-polydimethylsiloxane graft polymers are synthesised. Chemical characterisation of the polymer is performed by using Fourier Transform Infrared Spectroscopy and Gel Permeation Chromatography. In vitro hydrolytic degradation is carried out in which films are immersed at 37°C in alkaline solution. Degradation is assessed by tensile testing as a function of time to determine the degradation of mechanical strength, infrared spectroscopy, and mass loss. A titration method is also used to determine quantitatively the hydrolytic degradation. In order to study the adhesions of films, an in-vitro model based on a gelatine test, which is simple and rapid, is described. Suitable candidate films investigated from the in-vitro work are subjected to in vivo tests for both biodegradation and their ability to prevent adhesion.
AB - Adhesions commonly occur after internal disease or surgery. The natural healing response leads to the formation of vascular and avascular adhesions after inflammatory diseases and surgical interventions. A barrier film could be incorporated during surgery between layers of tissues that must not adhere to one another. The film would be biodegradable so that it disappears over a period of time, and would ideally be two sided, allowing relative movement at that interface, while being firmly anchored on the opposite side to prevent displacement. Polyesterurethane-polydimethylsiloxane graft polymers are synthesised. Chemical characterisation of the polymer is performed by using Fourier Transform Infrared Spectroscopy and Gel Permeation Chromatography. In vitro hydrolytic degradation is carried out in which films are immersed at 37°C in alkaline solution. Degradation is assessed by tensile testing as a function of time to determine the degradation of mechanical strength, infrared spectroscopy, and mass loss. A titration method is also used to determine quantitatively the hydrolytic degradation. In order to study the adhesions of films, an in-vitro model based on a gelatine test, which is simple and rapid, is described. Suitable candidate films investigated from the in-vitro work are subjected to in vivo tests for both biodegradation and their ability to prevent adhesion.
KW - Adhesions
KW - Characterisation co-polymers hydrolytic degradation
KW - In-vitro
KW - In-vivo
KW - Polyesters
KW - Polyurethanes
KW - Synthesis
KW - Adhesion
KW - Biofilms
KW - Degradation
KW - Fourier transform infrared spectroscopy
KW - Gel permeation chromatography
KW - Graft copolymers
KW - Strength of materials
KW - Surgery
KW - Titration
KW - Avascular adhesion
KW - Biodegradable low adherence films
KW - Biodegradable polyurethanes
KW - Hydrolytic degradation
KW - Vascular adhesion
KW - biomaterial
KW - polymer
KW - polyurethan
KW - adhesion
KW - animal
KW - article
KW - bioremediation
KW - chemistry
KW - comparative study
KW - materials testing
KW - methodology
KW - postoperative complication
KW - rat
KW - structure activity relation
KW - synthesis
KW - Adhesiveness
KW - Animals
KW - Biocompatible Materials
KW - Biodegradation, Environmental
KW - Materials Testing
KW - Polymers
KW - Postoperative Complications
KW - Rats
KW - Structure-Activity Relationship
U2 - 10.1177/088532829601100203
DO - 10.1177/088532829601100203
M3 - Journal article
VL - 11
SP - 182
EP - 257
JO - JOURNAL OF BIOMATERIALS APPLICATIONS
JF - JOURNAL OF BIOMATERIALS APPLICATIONS
SN - 0885-3282
IS - 2
ER -