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Biological behavior of bioactive glasses and their composites

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Biological behavior of bioactive glasses and their composites. / Zahid, S.; Shah, A.T.; Jamal, A. et al.
In: RSC Advances, Vol. 6, No. 74, 01.08.2016, p. 70197-70214.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Zahid, S, Shah, AT, Jamal, A, Chaudhry, AA, Khan, AS, Khan, AF, Muhammad, N & Rehman, IU 2016, 'Biological behavior of bioactive glasses and their composites', RSC Advances, vol. 6, no. 74, pp. 70197-70214. https://doi.org/10.1039/c6ra07819b

APA

Zahid, S., Shah, A. T., Jamal, A., Chaudhry, A. A., Khan, A. S., Khan, A. F., Muhammad, N., & Rehman, I. U. (2016). Biological behavior of bioactive glasses and their composites. RSC Advances, 6(74), 70197-70214. https://doi.org/10.1039/c6ra07819b

Vancouver

Zahid S, Shah AT, Jamal A, Chaudhry AA, Khan AS, Khan AF et al. Biological behavior of bioactive glasses and their composites. RSC Advances. 2016 Aug 1;6(74):70197-70214. Epub 2016 Jul 8. doi: 10.1039/c6ra07819b

Author

Zahid, S. ; Shah, A.T. ; Jamal, A. et al. / Biological behavior of bioactive glasses and their composites. In: RSC Advances. 2016 ; Vol. 6, No. 74. pp. 70197-70214.

Bibtex

@article{b2d259d91caa430ca9d0dc5111e1321c,
title = "Biological behavior of bioactive glasses and their composites",
abstract = "Bioactive glasses (BGs) as third generation biomaterials have the ability to form an interfacial bonding more rapidly than other bioceramics between implant and host tissues in defect treatment. Therefore, BGs have shown great applications in the field of bone tissue engineering, dental materials, skin and other tissue regeneration. This review is based on inorganic and organic BG composites being used in bone tissue engineering and summarizes current developments in improving the biological behavior of BGs and their composites. A main focus was given to highlight the role of BGs and their composites in osteogenic differentiation and angiogenesis, followed by their cytotoxicity, protein adsorption ability and antibacterial properties. BGs were found to enhance the cell proliferation and cell attachment without any toxic effects with a significant increase in metabolic activity and possess osteogenic properties. Organic and inorganic dopants have been used to improve their cytocompatibility, osteoconductivity and promote stem cell differentiation towards the osteogenic lineage. BGs have also been used as graft materials because of their significant role in angiogenesis, as they stimulate relevant cells (i.e. fibroblasts, osteoblasts and endothelial cells) to release angiogenic growth factors. They show good protein adsorption because they act as templates for the adsorption of proteins which in turn depends upon surface properties. Antibacterial effects were also observed in BGs as a result of the high aqueous pH value in body fluids due to the presence of alkaline ions. There has been significant research work performed on silica-based bioactive glasses but not much literature can be found on phosphate- and borate-based bioactive glasses, which have good solubility and degradation, respectively. {\textcopyright} The Royal Society of Chemistry 2016.",
keywords = "Adsorption, Alkalinity, Bioactive glass, Bioceramics, Biomaterials, Bone, Cell culture, Cell proliferation, Cells, Cytology, Dental materials, Endothelial cells, Engineering research, Glass, Osteoblasts, Proteins, Stem cells, Tissue, Tissue engineering, Adsorption of proteins, Angiogenic growth factors, Antibacterial effects, Antibacterial properties, Bone tissue engineering, Interfacial bonding, Osteogenic differentiation, Stem cell differentiation, Tissue regeneration",
author = "S. Zahid and A.T. Shah and A. Jamal and A.A. Chaudhry and A.S. Khan and A.F. Khan and N. Muhammad and I.U. Rehman",
year = "2016",
month = aug,
day = "1",
doi = "10.1039/c6ra07819b",
language = "English",
volume = "6",
pages = "70197--70214",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "74",

}

RIS

TY - JOUR

T1 - Biological behavior of bioactive glasses and their composites

AU - Zahid, S.

AU - Shah, A.T.

AU - Jamal, A.

AU - Chaudhry, A.A.

AU - Khan, A.S.

AU - Khan, A.F.

AU - Muhammad, N.

AU - Rehman, I.U.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Bioactive glasses (BGs) as third generation biomaterials have the ability to form an interfacial bonding more rapidly than other bioceramics between implant and host tissues in defect treatment. Therefore, BGs have shown great applications in the field of bone tissue engineering, dental materials, skin and other tissue regeneration. This review is based on inorganic and organic BG composites being used in bone tissue engineering and summarizes current developments in improving the biological behavior of BGs and their composites. A main focus was given to highlight the role of BGs and their composites in osteogenic differentiation and angiogenesis, followed by their cytotoxicity, protein adsorption ability and antibacterial properties. BGs were found to enhance the cell proliferation and cell attachment without any toxic effects with a significant increase in metabolic activity and possess osteogenic properties. Organic and inorganic dopants have been used to improve their cytocompatibility, osteoconductivity and promote stem cell differentiation towards the osteogenic lineage. BGs have also been used as graft materials because of their significant role in angiogenesis, as they stimulate relevant cells (i.e. fibroblasts, osteoblasts and endothelial cells) to release angiogenic growth factors. They show good protein adsorption because they act as templates for the adsorption of proteins which in turn depends upon surface properties. Antibacterial effects were also observed in BGs as a result of the high aqueous pH value in body fluids due to the presence of alkaline ions. There has been significant research work performed on silica-based bioactive glasses but not much literature can be found on phosphate- and borate-based bioactive glasses, which have good solubility and degradation, respectively. © The Royal Society of Chemistry 2016.

AB - Bioactive glasses (BGs) as third generation biomaterials have the ability to form an interfacial bonding more rapidly than other bioceramics between implant and host tissues in defect treatment. Therefore, BGs have shown great applications in the field of bone tissue engineering, dental materials, skin and other tissue regeneration. This review is based on inorganic and organic BG composites being used in bone tissue engineering and summarizes current developments in improving the biological behavior of BGs and their composites. A main focus was given to highlight the role of BGs and their composites in osteogenic differentiation and angiogenesis, followed by their cytotoxicity, protein adsorption ability and antibacterial properties. BGs were found to enhance the cell proliferation and cell attachment without any toxic effects with a significant increase in metabolic activity and possess osteogenic properties. Organic and inorganic dopants have been used to improve their cytocompatibility, osteoconductivity and promote stem cell differentiation towards the osteogenic lineage. BGs have also been used as graft materials because of their significant role in angiogenesis, as they stimulate relevant cells (i.e. fibroblasts, osteoblasts and endothelial cells) to release angiogenic growth factors. They show good protein adsorption because they act as templates for the adsorption of proteins which in turn depends upon surface properties. Antibacterial effects were also observed in BGs as a result of the high aqueous pH value in body fluids due to the presence of alkaline ions. There has been significant research work performed on silica-based bioactive glasses but not much literature can be found on phosphate- and borate-based bioactive glasses, which have good solubility and degradation, respectively. © The Royal Society of Chemistry 2016.

KW - Adsorption

KW - Alkalinity

KW - Bioactive glass

KW - Bioceramics

KW - Biomaterials

KW - Bone

KW - Cell culture

KW - Cell proliferation

KW - Cells

KW - Cytology

KW - Dental materials

KW - Endothelial cells

KW - Engineering research

KW - Glass

KW - Osteoblasts

KW - Proteins

KW - Stem cells

KW - Tissue

KW - Tissue engineering

KW - Adsorption of proteins

KW - Angiogenic growth factors

KW - Antibacterial effects

KW - Antibacterial properties

KW - Bone tissue engineering

KW - Interfacial bonding

KW - Osteogenic differentiation

KW - Stem cell differentiation

KW - Tissue regeneration

U2 - 10.1039/c6ra07819b

DO - 10.1039/c6ra07819b

M3 - Journal article

VL - 6

SP - 70197

EP - 70214

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 74

ER -