Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Biological behavior of bioactive glasses and their composites
AU - Zahid, S.
AU - Shah, A.T.
AU - Jamal, A.
AU - Chaudhry, A.A.
AU - Khan, A.S.
AU - Khan, A.F.
AU - Muhammad, N.
AU - Rehman, I.U.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Bioactive glasses (BGs) as third generation biomaterials have the ability to form an interfacial bonding more rapidly than other bioceramics between implant and host tissues in defect treatment. Therefore, BGs have shown great applications in the field of bone tissue engineering, dental materials, skin and other tissue regeneration. This review is based on inorganic and organic BG composites being used in bone tissue engineering and summarizes current developments in improving the biological behavior of BGs and their composites. A main focus was given to highlight the role of BGs and their composites in osteogenic differentiation and angiogenesis, followed by their cytotoxicity, protein adsorption ability and antibacterial properties. BGs were found to enhance the cell proliferation and cell attachment without any toxic effects with a significant increase in metabolic activity and possess osteogenic properties. Organic and inorganic dopants have been used to improve their cytocompatibility, osteoconductivity and promote stem cell differentiation towards the osteogenic lineage. BGs have also been used as graft materials because of their significant role in angiogenesis, as they stimulate relevant cells (i.e. fibroblasts, osteoblasts and endothelial cells) to release angiogenic growth factors. They show good protein adsorption because they act as templates for the adsorption of proteins which in turn depends upon surface properties. Antibacterial effects were also observed in BGs as a result of the high aqueous pH value in body fluids due to the presence of alkaline ions. There has been significant research work performed on silica-based bioactive glasses but not much literature can be found on phosphate- and borate-based bioactive glasses, which have good solubility and degradation, respectively. © The Royal Society of Chemistry 2016.
AB - Bioactive glasses (BGs) as third generation biomaterials have the ability to form an interfacial bonding more rapidly than other bioceramics between implant and host tissues in defect treatment. Therefore, BGs have shown great applications in the field of bone tissue engineering, dental materials, skin and other tissue regeneration. This review is based on inorganic and organic BG composites being used in bone tissue engineering and summarizes current developments in improving the biological behavior of BGs and their composites. A main focus was given to highlight the role of BGs and their composites in osteogenic differentiation and angiogenesis, followed by their cytotoxicity, protein adsorption ability and antibacterial properties. BGs were found to enhance the cell proliferation and cell attachment without any toxic effects with a significant increase in metabolic activity and possess osteogenic properties. Organic and inorganic dopants have been used to improve their cytocompatibility, osteoconductivity and promote stem cell differentiation towards the osteogenic lineage. BGs have also been used as graft materials because of their significant role in angiogenesis, as they stimulate relevant cells (i.e. fibroblasts, osteoblasts and endothelial cells) to release angiogenic growth factors. They show good protein adsorption because they act as templates for the adsorption of proteins which in turn depends upon surface properties. Antibacterial effects were also observed in BGs as a result of the high aqueous pH value in body fluids due to the presence of alkaline ions. There has been significant research work performed on silica-based bioactive glasses but not much literature can be found on phosphate- and borate-based bioactive glasses, which have good solubility and degradation, respectively. © The Royal Society of Chemistry 2016.
KW - Adsorption
KW - Alkalinity
KW - Bioactive glass
KW - Bioceramics
KW - Biomaterials
KW - Bone
KW - Cell culture
KW - Cell proliferation
KW - Cells
KW - Cytology
KW - Dental materials
KW - Endothelial cells
KW - Engineering research
KW - Glass
KW - Osteoblasts
KW - Proteins
KW - Stem cells
KW - Tissue
KW - Tissue engineering
KW - Adsorption of proteins
KW - Angiogenic growth factors
KW - Antibacterial effects
KW - Antibacterial properties
KW - Bone tissue engineering
KW - Interfacial bonding
KW - Osteogenic differentiation
KW - Stem cell differentiation
KW - Tissue regeneration
U2 - 10.1039/c6ra07819b
DO - 10.1039/c6ra07819b
M3 - Journal article
VL - 6
SP - 70197
EP - 70214
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 74
ER -