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Biological insights from 108 schizophrenia-associated genetic loci

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Biological insights from 108 schizophrenia-associated genetic loci. / Schizophrenia Working Group of the Psychiatric Genomics Consortium.

In: Nature, Vol. 511, No. 7510, 24.07.2014, p. 421-427.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Schizophrenia Working Group of the Psychiatric Genomics Consortium 2014, 'Biological insights from 108 schizophrenia-associated genetic loci', Nature, vol. 511, no. 7510, pp. 421-427. https://doi.org/10.1038/nature13595

APA

Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511(7510), 421-427. https://doi.org/10.1038/nature13595

Vancouver

Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014 Jul 24;511(7510):421-427. Epub 2014 Jul 22. doi: 10.1038/nature13595

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Schizophrenia Working Group of the Psychiatric Genomics Consortium. / Biological insights from 108 schizophrenia-associated genetic loci. In: Nature. 2014 ; Vol. 511, No. 7510. pp. 421-427.

Bibtex

@article{f853cd2451ea4abe93e1bae8f2df60ee,
title = "Biological insights from 108 schizophrenia-associated genetic loci",
abstract = "Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.",
keywords = "Alleles, Brain, Enhancer Elements, Genetic, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Glutamic Acid, Humans, Immunity, Multifactorial Inheritance, Mutation, Odds Ratio, Polymorphism, Single Nucleotide, Schizophrenia, Synaptic Transmission",
author = "{Schizophrenia Working Group of the Psychiatric Genomics Consortium} and Jo Knight",
year = "2014",
month = jul,
day = "24",
doi = "10.1038/nature13595",
language = "English",
volume = "511",
pages = "421--427",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7510",

}

RIS

TY - JOUR

T1 - Biological insights from 108 schizophrenia-associated genetic loci

AU - Schizophrenia Working Group of the Psychiatric Genomics Consortium

AU - Knight, Jo

PY - 2014/7/24

Y1 - 2014/7/24

N2 - Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

AB - Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

KW - Alleles

KW - Brain

KW - Enhancer Elements, Genetic

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Glutamic Acid

KW - Humans

KW - Immunity

KW - Multifactorial Inheritance

KW - Mutation

KW - Odds Ratio

KW - Polymorphism, Single Nucleotide

KW - Schizophrenia

KW - Synaptic Transmission

U2 - 10.1038/nature13595

DO - 10.1038/nature13595

M3 - Journal article

C2 - 25056061

VL - 511

SP - 421

EP - 427

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7510

ER -