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Biomarkers for knee osteoarthritis: new technologies, new paradigms

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Biomarkers for knee osteoarthritis : new technologies, new paradigms. / Spain, Lucy; Rajoub, Bashar ; Schlueter, Daniela K.; Waterton, John ; Bowes, Mike; Shark, Lik-Kwan; Diggle, Peter; Goodacre, John.

In: International Journal of Clinical Rheumatology, Vol. 10, No. 4, 10.2015, p. 287-297.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Spain, L, Rajoub, B, Schlueter, DK, Waterton, J, Bowes, M, Shark, L-K, Diggle, P & Goodacre, J 2015, 'Biomarkers for knee osteoarthritis: new technologies, new paradigms', International Journal of Clinical Rheumatology, vol. 10, no. 4, pp. 287-297. https://doi.org/10.2217/ijr.15.32

APA

Spain, L., Rajoub, B., Schlueter, D. K., Waterton, J., Bowes, M., Shark, L-K., Diggle, P., & Goodacre, J. (2015). Biomarkers for knee osteoarthritis: new technologies, new paradigms. International Journal of Clinical Rheumatology, 10(4), 287-297. https://doi.org/10.2217/ijr.15.32

Vancouver

Spain L, Rajoub B, Schlueter DK, Waterton J, Bowes M, Shark L-K et al. Biomarkers for knee osteoarthritis: new technologies, new paradigms. International Journal of Clinical Rheumatology. 2015 Oct;10(4):287-297. https://doi.org/10.2217/ijr.15.32

Author

Spain, Lucy ; Rajoub, Bashar ; Schlueter, Daniela K. ; Waterton, John ; Bowes, Mike ; Shark, Lik-Kwan ; Diggle, Peter ; Goodacre, John. / Biomarkers for knee osteoarthritis : new technologies, new paradigms. In: International Journal of Clinical Rheumatology. 2015 ; Vol. 10, No. 4. pp. 287-297.

Bibtex

@article{78de2caf707842e3ab29c5c87a7ccee5,
title = "Biomarkers for knee osteoarthritis: new technologies, new paradigms",
abstract = "There is a paucity of biomarkers in knee osteoarthritis (OA) to inform clinical decision making, evaluate treatments, enable early detection and identify people who are most likely to progress to severe OA. The absence of biomarkers places considerable limitations on the design of research studies, and is a barrier toward applying the principles of stratified medicine to knee OA. Here we describe key principles and processes of biomarker development and focus on two promising areas that draw upon technologies that have only relatively recently been developed for quantitative applications in clinical research, namely 3D MRI and acoustic emission. While still at an early stage, results to date show promising potential to open up interesting new paradigms in this field.",
keywords = "3D MRI, acoustic emission, biomarker, knee osteoarthritis",
author = "Lucy Spain and Bashar Rajoub and Schlueter, {Daniela K.} and John Waterton and Mike Bowes and Lik-Kwan Shark and Peter Diggle and John Goodacre",
note = "Date of Acceptance unknown. Corresponding author does not have the information.",
year = "2015",
month = oct,
doi = "10.2217/ijr.15.32",
language = "English",
volume = "10",
pages = "287--297",
journal = "International Journal of Clinical Rheumatology",
issn = "1758-4272",
publisher = "Future Medicine Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Biomarkers for knee osteoarthritis

T2 - new technologies, new paradigms

AU - Spain, Lucy

AU - Rajoub, Bashar

AU - Schlueter, Daniela K.

AU - Waterton, John

AU - Bowes, Mike

AU - Shark, Lik-Kwan

AU - Diggle, Peter

AU - Goodacre, John

N1 - Date of Acceptance unknown. Corresponding author does not have the information.

PY - 2015/10

Y1 - 2015/10

N2 - There is a paucity of biomarkers in knee osteoarthritis (OA) to inform clinical decision making, evaluate treatments, enable early detection and identify people who are most likely to progress to severe OA. The absence of biomarkers places considerable limitations on the design of research studies, and is a barrier toward applying the principles of stratified medicine to knee OA. Here we describe key principles and processes of biomarker development and focus on two promising areas that draw upon technologies that have only relatively recently been developed for quantitative applications in clinical research, namely 3D MRI and acoustic emission. While still at an early stage, results to date show promising potential to open up interesting new paradigms in this field.

AB - There is a paucity of biomarkers in knee osteoarthritis (OA) to inform clinical decision making, evaluate treatments, enable early detection and identify people who are most likely to progress to severe OA. The absence of biomarkers places considerable limitations on the design of research studies, and is a barrier toward applying the principles of stratified medicine to knee OA. Here we describe key principles and processes of biomarker development and focus on two promising areas that draw upon technologies that have only relatively recently been developed for quantitative applications in clinical research, namely 3D MRI and acoustic emission. While still at an early stage, results to date show promising potential to open up interesting new paradigms in this field.

KW - 3D MRI

KW - acoustic emission

KW - biomarker

KW - knee osteoarthritis

U2 - 10.2217/ijr.15.32

DO - 10.2217/ijr.15.32

M3 - Journal article

VL - 10

SP - 287

EP - 297

JO - International Journal of Clinical Rheumatology

JF - International Journal of Clinical Rheumatology

SN - 1758-4272

IS - 4

ER -