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Boron nitride doped polyhydroxyalkanoate/chitosan nanocomposite for antibacterial and biological applications

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Boron nitride doped polyhydroxyalkanoate/chitosan nanocomposite for antibacterial and biological applications. / Mukheem, A.; Shahabuddin, S.; Akbar, N. et al.
In: Nanomaterials, Vol. 9, No. 4, 645, 21.04.2019.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Mukheem, A, Shahabuddin, S, Akbar, N, Miskon, A, Sarih, NM, Sudesh, K, Khan, NA, Saidur, R & Sridewi, N 2019, 'Boron nitride doped polyhydroxyalkanoate/chitosan nanocomposite for antibacterial and biological applications', Nanomaterials, vol. 9, no. 4, 645. https://doi.org/10.3390/nano9040645

APA

Mukheem, A., Shahabuddin, S., Akbar, N., Miskon, A., Sarih, N. M., Sudesh, K., Khan, N. A., Saidur, R., & Sridewi, N. (2019). Boron nitride doped polyhydroxyalkanoate/chitosan nanocomposite for antibacterial and biological applications. Nanomaterials, 9(4), Article 645. https://doi.org/10.3390/nano9040645

Vancouver

Mukheem A, Shahabuddin S, Akbar N, Miskon A, Sarih NM, Sudesh K et al. Boron nitride doped polyhydroxyalkanoate/chitosan nanocomposite for antibacterial and biological applications. Nanomaterials. 2019 Apr 21;9(4):645. doi: 10.3390/nano9040645

Author

Mukheem, A. ; Shahabuddin, S. ; Akbar, N. et al. / Boron nitride doped polyhydroxyalkanoate/chitosan nanocomposite for antibacterial and biological applications. In: Nanomaterials. 2019 ; Vol. 9, No. 4.

Bibtex

@article{74352d5a2a704cc3989f35edb029463e,
title = "Boron nitride doped polyhydroxyalkanoate/chitosan nanocomposite for antibacterial and biological applications",
abstract = "The present research focused on the fabrication of biocompatible polyhydroxyalkanoate, chitosan, and hexagonal boron nitride incorporated (PHA/Ch-hBN) nanocomposites through a simple solvent casting technique. The fabricated nanocomposites were comprehensively characterized by Fourier transform infrared spectroscope (FT-IR), field emission scanning electroscope (FESEM), and elemental mapping and thermogravimetric analysis (TGA). The antibacterial activity of nanocomposites were investigated through time-kill method against multi drug resistant (MDR) microbes such as methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) K1 strains. In addition, nanocomposites have examined for their host cytotoxicity abilities using a Lactate dehydrogenase (LDH) assay against spontaneously immortalized human keratinocytes (HaCaT) cell lines. The results demonstrated highly significant antibacterial activity against MDR organisms and also significant cell viability as compared to the positive control. The fabricated PHA/Ch-hBN nanocomposite demonstrated effective antimicrobial and biocompatibility properties that would feasibly suit antibacterial and biomedical applications. ",
keywords = "Antibacterial, Biocompatible, Boron nitride, Chitosan, Nanocomposite, Polyhydroxyalkanoate",
author = "A. Mukheem and S. Shahabuddin and N. Akbar and A. Miskon and N.M. Sarih and K. Sudesh and N.A. Khan and Rahman Saidur and N. Sridewi",
year = "2019",
month = apr,
day = "21",
doi = "10.3390/nano9040645",
language = "English",
volume = "9",
journal = "Nanomaterials",
issn = "2079-4991",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Boron nitride doped polyhydroxyalkanoate/chitosan nanocomposite for antibacterial and biological applications

AU - Mukheem, A.

AU - Shahabuddin, S.

AU - Akbar, N.

AU - Miskon, A.

AU - Sarih, N.M.

AU - Sudesh, K.

AU - Khan, N.A.

AU - Saidur, Rahman

AU - Sridewi, N.

PY - 2019/4/21

Y1 - 2019/4/21

N2 - The present research focused on the fabrication of biocompatible polyhydroxyalkanoate, chitosan, and hexagonal boron nitride incorporated (PHA/Ch-hBN) nanocomposites through a simple solvent casting technique. The fabricated nanocomposites were comprehensively characterized by Fourier transform infrared spectroscope (FT-IR), field emission scanning electroscope (FESEM), and elemental mapping and thermogravimetric analysis (TGA). The antibacterial activity of nanocomposites were investigated through time-kill method against multi drug resistant (MDR) microbes such as methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) K1 strains. In addition, nanocomposites have examined for their host cytotoxicity abilities using a Lactate dehydrogenase (LDH) assay against spontaneously immortalized human keratinocytes (HaCaT) cell lines. The results demonstrated highly significant antibacterial activity against MDR organisms and also significant cell viability as compared to the positive control. The fabricated PHA/Ch-hBN nanocomposite demonstrated effective antimicrobial and biocompatibility properties that would feasibly suit antibacterial and biomedical applications.

AB - The present research focused on the fabrication of biocompatible polyhydroxyalkanoate, chitosan, and hexagonal boron nitride incorporated (PHA/Ch-hBN) nanocomposites through a simple solvent casting technique. The fabricated nanocomposites were comprehensively characterized by Fourier transform infrared spectroscope (FT-IR), field emission scanning electroscope (FESEM), and elemental mapping and thermogravimetric analysis (TGA). The antibacterial activity of nanocomposites were investigated through time-kill method against multi drug resistant (MDR) microbes such as methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) K1 strains. In addition, nanocomposites have examined for their host cytotoxicity abilities using a Lactate dehydrogenase (LDH) assay against spontaneously immortalized human keratinocytes (HaCaT) cell lines. The results demonstrated highly significant antibacterial activity against MDR organisms and also significant cell viability as compared to the positive control. The fabricated PHA/Ch-hBN nanocomposite demonstrated effective antimicrobial and biocompatibility properties that would feasibly suit antibacterial and biomedical applications.

KW - Antibacterial

KW - Biocompatible

KW - Boron nitride

KW - Chitosan

KW - Nanocomposite

KW - Polyhydroxyalkanoate

U2 - 10.3390/nano9040645

DO - 10.3390/nano9040645

M3 - Journal article

VL - 9

JO - Nanomaterials

JF - Nanomaterials

SN - 2079-4991

IS - 4

M1 - 645

ER -