In November 2010, the then British Foreign Secretary William Hague delivered Canning House's annual lecture on the topic of Britain's relations with Latin America. In launching the so-called ‘Canning Agenda’, Hague pledged to ‘halt the decline in Britain's diplomatic presence in Latin America’. ‘It is now time’, Hague went on, ‘for an advance to begin’. This article represents the first scholarly analysis of this policy. In particular, it assesses British efforts to enhance its economic ties with the countries of Latin America; the status granted to Latin America in Britain's strategic world-view in the post-Brexit era; the impact on Britain of other external powers in the region; and the political relationships between Britain and the countries of Latin America. The article draws on interviews with the key policy-makers involved in the Canning Agenda, including William Hague, Sir Hugo Swire, Jeremy Browne, and several other officials and diplomats from Britain and throughout Latin America. It concludes that while an identifiable effort to enhance Britain's economic and political standing in Latin America is discernible since 2010, major impediments to achieving this goal persist across the range of areas explored.