This paper discusses how impact-oriented agricultural research for development systems in Africa can be better organized and managed. Specifically, the paper puts forth the argument that achieving the development targets set by African leaders and the international community, for example, through the Millennium Development Goals, will be extremely difficult without a satisfactory re-orientation of the organization and management of African research for development systems. Such a re-orientation involves carefully linking the agricultural research agenda with national development priorities; improving coordination, interaction, interlinkages, partnerships, and networks among system agents—that is, agricultural research institutes, extension systems, higher education institutions, farmer organizations, civil society, and the private sector—and finding innovative financing and resourcing mechanisms to support the numerous components of the system.