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Calcium dependence of electrical and mechanical activity in rat ileum examined by the sucrose-gap technique.

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Calcium dependence of electrical and mechanical activity in rat ileum examined by the sucrose-gap technique. / Mahmod, S. M.; Huddart, H.
In: Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, Vol. 105, No. 3, 1993, p. 387-391.

Research output: Contribution to Journal/Magazine › Journal article

Harvard

Mahmod, SM & Huddart, H 1993, 'Calcium dependence of electrical and mechanical activity in rat ileum examined by the sucrose-gap technique.', Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, vol. 105, no. 3, pp. 387-391. https://doi.org/10.1016/0742-8413(93)90075-V

APA

Mahmod, S. M., & Huddart, H. (1993). Calcium dependence of electrical and mechanical activity in rat ileum examined by the sucrose-gap technique. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 105(3), 387-391. https://doi.org/10.1016/0742-8413(93)90075-V

Vancouver

Mahmod SM, Huddart H. Calcium dependence of electrical and mechanical activity in rat ileum examined by the sucrose-gap technique. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 1993;105(3):387-391. doi: 10.1016/0742-8413(93)90075-V

Author

Mahmod, S. M. ; Huddart, H. / Calcium dependence of electrical and mechanical activity in rat ileum examined by the sucrose-gap technique. In: Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 1993 ; Vol. 105, No. 3. pp. 387-391.

Bibtex

@article{d15ac71b53af4d28bf3c2aa2b30b57e9,
title = "Calcium dependence of electrical and mechanical activity in rat ileum examined by the sucrose-gap technique.",
abstract = "1. Single sucrose gap recordings showed that spontaneous action potentials of rat ileal smooth muscle consisted of slow waves and superimposed spikes which generated rhythmic contractions. As external potassium was raised, the resting potential progressively depolarized.2. Calcium-free salines inhibited spontaneous mechanical activity and inhibited the plateau phase of the action potential, but spontaneous spike depolarizations persisted.3. Verapamil, nifedipine and diltiazem all inhibited spontaneous mechanical activity and the plateau phase of the action potential, while in addition diltiazem augmented spike amplitude.4. Mn ions also inhibited mechanical activity and the action potential plateau, without affecting spike activity while the calcium ionophore A23187 enhanced both mechanical and electrical activity with a pronounced effect on spike amplitude.5. These results are consistent with the view that the plateau phase of the ileal smooth muscle action potential is dependent upon an influx of extracellular calcium possibly through voltage dependent slow calcium channels.",
keywords = "Ileum, Action potential, Smooth muscle, Muscle contraction, Ionic channel, Calcium, Rat, Small intestine, Digestive system, Electrophysiology, Rodentia, Mammalia, Vertebrata",
author = "Mahmod, {S. M.} and H. Huddart",
year = "1993",
doi = "10.1016/0742-8413(93)90075-V",
language = "English",
volume = "105",
pages = "387--391",
journal = "Comparative Biochemistry and Physiology Part C: Comparative Pharmacology",
issn = "0306-4492",
publisher = "Elsevier BV",
number = "3",

}

RIS

TY - JOUR

T1 - Calcium dependence of electrical and mechanical activity in rat ileum examined by the sucrose-gap technique.

AU - Mahmod, S. M.

AU - Huddart, H.

PY - 1993

Y1 - 1993

N2 - 1. Single sucrose gap recordings showed that spontaneous action potentials of rat ileal smooth muscle consisted of slow waves and superimposed spikes which generated rhythmic contractions. As external potassium was raised, the resting potential progressively depolarized.2. Calcium-free salines inhibited spontaneous mechanical activity and inhibited the plateau phase of the action potential, but spontaneous spike depolarizations persisted.3. Verapamil, nifedipine and diltiazem all inhibited spontaneous mechanical activity and the plateau phase of the action potential, while in addition diltiazem augmented spike amplitude.4. Mn ions also inhibited mechanical activity and the action potential plateau, without affecting spike activity while the calcium ionophore A23187 enhanced both mechanical and electrical activity with a pronounced effect on spike amplitude.5. These results are consistent with the view that the plateau phase of the ileal smooth muscle action potential is dependent upon an influx of extracellular calcium possibly through voltage dependent slow calcium channels.

AB - 1. Single sucrose gap recordings showed that spontaneous action potentials of rat ileal smooth muscle consisted of slow waves and superimposed spikes which generated rhythmic contractions. As external potassium was raised, the resting potential progressively depolarized.2. Calcium-free salines inhibited spontaneous mechanical activity and inhibited the plateau phase of the action potential, but spontaneous spike depolarizations persisted.3. Verapamil, nifedipine and diltiazem all inhibited spontaneous mechanical activity and the plateau phase of the action potential, while in addition diltiazem augmented spike amplitude.4. Mn ions also inhibited mechanical activity and the action potential plateau, without affecting spike activity while the calcium ionophore A23187 enhanced both mechanical and electrical activity with a pronounced effect on spike amplitude.5. These results are consistent with the view that the plateau phase of the ileal smooth muscle action potential is dependent upon an influx of extracellular calcium possibly through voltage dependent slow calcium channels.

KW - Ileum

KW - Action potential

KW - Smooth muscle

KW - Muscle contraction

KW - Ionic channel

KW - Calcium

KW - Rat

KW - Small intestine

KW - Digestive system

KW - Electrophysiology

KW - Rodentia

KW - Mammalia

KW - Vertebrata

U2 - 10.1016/0742-8413(93)90075-V

DO - 10.1016/0742-8413(93)90075-V

M3 - Journal article

VL - 105

SP - 387

EP - 391

JO - Comparative Biochemistry and Physiology Part C: Comparative Pharmacology

JF - Comparative Biochemistry and Physiology Part C: Comparative Pharmacology

SN - 0306-4492

IS - 3

ER -