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Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion

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Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion. / Vynckier, A. K.; Lin, Hungyen; Zeitler, J. Axel et al.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 96, 2015, p. 125-131.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Vynckier, AK, Lin, H, Zeitler, JA, Willart, JF, Bongaers, E, Voorspoels, J, Remon, JP & Vervaet, C 2015, 'Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion', European Journal of Pharmaceutics and Biopharmaceutics, vol. 96, pp. 125-131. https://doi.org/10.1016/j.ejpb.2015.07.023

APA

Vynckier, A. K., Lin, H., Zeitler, J. A., Willart, J. F., Bongaers, E., Voorspoels, J., Remon, J. P., & Vervaet, C. (2015). Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion. European Journal of Pharmaceutics and Biopharmaceutics, 96, 125-131. https://doi.org/10.1016/j.ejpb.2015.07.023

Vancouver

Vynckier AK, Lin H, Zeitler JA, Willart JF, Bongaers E, Voorspoels J et al. Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion. European Journal of Pharmaceutics and Biopharmaceutics. 2015;96:125-131. doi: 10.1016/j.ejpb.2015.07.023

Author

Vynckier, A. K. ; Lin, Hungyen ; Zeitler, J. Axel et al. / Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion. In: European Journal of Pharmaceutics and Biopharmaceutics. 2015 ; Vol. 96. pp. 125-131.

Bibtex

@article{0dec43c27e27487dbc8d81eccf996df9,
title = "Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion",
abstract = "In this study calendering is used as a downstream technique to shape monolithic co-extruded fixed-dose combination products in a continuous way. Co-extrudates with a metoprolol tartrate-loaded sustained-release core and a hydrochlorothiazide-loaded immediate-release coat were produced and immediately shaped into a monolithic drug delivery system via calendering, using chilled rolls with tablet-shaped cavities. In vitro metoprolol tartrate release from the ethylcellulose core of the calendered tablets was prolonged in comparison with the sustained release of a multiparticulate dosage form, prepared manually by cutting co-extrudates into mini-matrices. Analysis of the dosage forms using X-ray micro-computed tomography only detected small differences between the pore structure of the core of the calendered tablet and the mini-matrices. Diffusion path length was shown to be the main mechanism behind the release kinetics. Terahertz pulsed imaging visualized that adhesion between the core and coat of the calendered tablet was not complete and a gradient in coat thickness (varying from 200 to 600 μm) was observed. Modulated differential scanning calorimetry and X-ray diffraction indicated that the solid-state properties of both drugs were not affected by the calendering procedure.",
author = "Vynckier, {A. K.} and Hungyen Lin and Zeitler, {J. Axel} and Willart, {J. F.} and E. Bongaers and J. Voorspoels and Remon, {J. P.} and C. Vervaet",
year = "2015",
doi = "10.1016/j.ejpb.2015.07.023",
language = "English",
volume = "96",
pages = "125--131",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion

AU - Vynckier, A. K.

AU - Lin, Hungyen

AU - Zeitler, J. Axel

AU - Willart, J. F.

AU - Bongaers, E.

AU - Voorspoels, J.

AU - Remon, J. P.

AU - Vervaet, C.

PY - 2015

Y1 - 2015

N2 - In this study calendering is used as a downstream technique to shape monolithic co-extruded fixed-dose combination products in a continuous way. Co-extrudates with a metoprolol tartrate-loaded sustained-release core and a hydrochlorothiazide-loaded immediate-release coat were produced and immediately shaped into a monolithic drug delivery system via calendering, using chilled rolls with tablet-shaped cavities. In vitro metoprolol tartrate release from the ethylcellulose core of the calendered tablets was prolonged in comparison with the sustained release of a multiparticulate dosage form, prepared manually by cutting co-extrudates into mini-matrices. Analysis of the dosage forms using X-ray micro-computed tomography only detected small differences between the pore structure of the core of the calendered tablet and the mini-matrices. Diffusion path length was shown to be the main mechanism behind the release kinetics. Terahertz pulsed imaging visualized that adhesion between the core and coat of the calendered tablet was not complete and a gradient in coat thickness (varying from 200 to 600 μm) was observed. Modulated differential scanning calorimetry and X-ray diffraction indicated that the solid-state properties of both drugs were not affected by the calendering procedure.

AB - In this study calendering is used as a downstream technique to shape monolithic co-extruded fixed-dose combination products in a continuous way. Co-extrudates with a metoprolol tartrate-loaded sustained-release core and a hydrochlorothiazide-loaded immediate-release coat were produced and immediately shaped into a monolithic drug delivery system via calendering, using chilled rolls with tablet-shaped cavities. In vitro metoprolol tartrate release from the ethylcellulose core of the calendered tablets was prolonged in comparison with the sustained release of a multiparticulate dosage form, prepared manually by cutting co-extrudates into mini-matrices. Analysis of the dosage forms using X-ray micro-computed tomography only detected small differences between the pore structure of the core of the calendered tablet and the mini-matrices. Diffusion path length was shown to be the main mechanism behind the release kinetics. Terahertz pulsed imaging visualized that adhesion between the core and coat of the calendered tablet was not complete and a gradient in coat thickness (varying from 200 to 600 μm) was observed. Modulated differential scanning calorimetry and X-ray diffraction indicated that the solid-state properties of both drugs were not affected by the calendering procedure.

U2 - 10.1016/j.ejpb.2015.07.023

DO - 10.1016/j.ejpb.2015.07.023

M3 - Journal article

VL - 96

SP - 125

EP - 131

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

ER -