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Can arsenic bioavailability be predicted in soils using in vitro gastro-intestinal simulation?

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Can arsenic bioavailability be predicted in soils using in vitro gastro-intestinal simulation? / Sun, Yiming; Jones, Kevin; Sun, Zongquan et al.
In: Ecotoxicology and environmental safety, Vol. 275, 116235, 15.04.2024.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Sun, Y, Jones, K, Sun, Z, Shen, J, Bu, F, Ma, F & Gu, Q 2024, 'Can arsenic bioavailability be predicted in soils using in vitro gastro-intestinal simulation?', Ecotoxicology and environmental safety, vol. 275, 116235. https://doi.org/10.1016/j.ecoenv.2024.116235

APA

Sun, Y., Jones, K., Sun, Z., Shen, J., Bu, F., Ma, F., & Gu, Q. (2024). Can arsenic bioavailability be predicted in soils using in vitro gastro-intestinal simulation? Ecotoxicology and environmental safety, 275, Article 116235. https://doi.org/10.1016/j.ecoenv.2024.116235

Vancouver

Sun Y, Jones K, Sun Z, Shen J, Bu F, Ma F et al. Can arsenic bioavailability be predicted in soils using in vitro gastro-intestinal simulation? Ecotoxicology and environmental safety. 2024 Apr 15;275:116235. Epub 2024 Mar 22. doi: 10.1016/j.ecoenv.2024.116235

Author

Sun, Yiming ; Jones, Kevin ; Sun, Zongquan et al. / Can arsenic bioavailability be predicted in soils using in vitro gastro-intestinal simulation?. In: Ecotoxicology and environmental safety. 2024 ; Vol. 275.

Bibtex

@article{de57769be41f4b489b3110b1e100c688,
title = "Can arsenic bioavailability be predicted in soils using in vitro gastro-intestinal simulation?",
abstract = "Many gastrointestinal simulation methods have been used to predict bioavailability, but the suitability of different methods for the same metal(loid)s varies widely, which inevitably affects the accuracy of human health risk assessment. Arsenic is a common and important contaminant in many contaminated land situations. It can be readily absorbed and has teratogenic and mutagenic toxicity. Therefore, in this study, four the most commonly used in vitro simulation methods (the Physiologically Based Extraction Test (PBET), In Vitro Gastrointestinal Method (IVG), Soluble Bioavailability Research Consortium (SBRC), the Unified BARGE Method (UBM)) were tested against an in vivo animal live model, to evaluate their effectiveness for the prediction of soil As bioavailability in 10 industrially contaminated soils. The soil As relative bioavailability (RBA) varied between 15% and 68% in the different soils. As bioaccessibility differed between the 4 gastro-intestinal simulation methods. Gastric phase of UBM (UBMG) predicted As relative bioavailability the best of the 4 assays (R 2 = 0.81). This study provides theoretical and technical support to refine human health risk assessment of As in soils from urban industrial legacy contaminated sites. ",
keywords = "Human health risk assessment, Bioaccessibility, Metalloid, Relative bioavailability",
author = "Yiming Sun and Kevin Jones and Zongquan Sun and Jialun Shen and Fanyang Bu and Fujun Ma and Qingbao Gu",
year = "2024",
month = apr,
day = "15",
doi = "10.1016/j.ecoenv.2024.116235",
language = "English",
volume = "275",
journal = "Ecotoxicology and environmental safety",
issn = "1090-2414",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Can arsenic bioavailability be predicted in soils using in vitro gastro-intestinal simulation?

AU - Sun, Yiming

AU - Jones, Kevin

AU - Sun, Zongquan

AU - Shen, Jialun

AU - Bu, Fanyang

AU - Ma, Fujun

AU - Gu, Qingbao

PY - 2024/4/15

Y1 - 2024/4/15

N2 - Many gastrointestinal simulation methods have been used to predict bioavailability, but the suitability of different methods for the same metal(loid)s varies widely, which inevitably affects the accuracy of human health risk assessment. Arsenic is a common and important contaminant in many contaminated land situations. It can be readily absorbed and has teratogenic and mutagenic toxicity. Therefore, in this study, four the most commonly used in vitro simulation methods (the Physiologically Based Extraction Test (PBET), In Vitro Gastrointestinal Method (IVG), Soluble Bioavailability Research Consortium (SBRC), the Unified BARGE Method (UBM)) were tested against an in vivo animal live model, to evaluate their effectiveness for the prediction of soil As bioavailability in 10 industrially contaminated soils. The soil As relative bioavailability (RBA) varied between 15% and 68% in the different soils. As bioaccessibility differed between the 4 gastro-intestinal simulation methods. Gastric phase of UBM (UBMG) predicted As relative bioavailability the best of the 4 assays (R 2 = 0.81). This study provides theoretical and technical support to refine human health risk assessment of As in soils from urban industrial legacy contaminated sites.

AB - Many gastrointestinal simulation methods have been used to predict bioavailability, but the suitability of different methods for the same metal(loid)s varies widely, which inevitably affects the accuracy of human health risk assessment. Arsenic is a common and important contaminant in many contaminated land situations. It can be readily absorbed and has teratogenic and mutagenic toxicity. Therefore, in this study, four the most commonly used in vitro simulation methods (the Physiologically Based Extraction Test (PBET), In Vitro Gastrointestinal Method (IVG), Soluble Bioavailability Research Consortium (SBRC), the Unified BARGE Method (UBM)) were tested against an in vivo animal live model, to evaluate their effectiveness for the prediction of soil As bioavailability in 10 industrially contaminated soils. The soil As relative bioavailability (RBA) varied between 15% and 68% in the different soils. As bioaccessibility differed between the 4 gastro-intestinal simulation methods. Gastric phase of UBM (UBMG) predicted As relative bioavailability the best of the 4 assays (R 2 = 0.81). This study provides theoretical and technical support to refine human health risk assessment of As in soils from urban industrial legacy contaminated sites.

KW - Human health risk assessment

KW - Bioaccessibility

KW - Metalloid

KW - Relative bioavailability

U2 - 10.1016/j.ecoenv.2024.116235

DO - 10.1016/j.ecoenv.2024.116235

M3 - Journal article

C2 - 38520809

VL - 275

JO - Ecotoxicology and environmental safety

JF - Ecotoxicology and environmental safety

SN - 1090-2414

M1 - 116235

ER -