Home > Research > Publications & Outputs > Cellular immune responses against hepatitis C v...
View graph of relations

Cellular immune responses against hepatitis C virus: the evidence base 2002

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

Cellular immune responses against hepatitis C virus: the evidence base 2002. / Ward, S; Lauer, G; Isba, R et al.
In: Clinical and Experimental Immunology, Vol. 128, No. 2, 2002, p. 195-203.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Ward, S, Lauer, G, Isba, R, Walker, B & Klenerman, P 2002, 'Cellular immune responses against hepatitis C virus: the evidence base 2002', Clinical and Experimental Immunology, vol. 128, no. 2, pp. 195-203. https://doi.org/10.1046/j.1365-2249.2002.01840.x

APA

Ward, S., Lauer, G., Isba, R., Walker, B., & Klenerman, P. (2002). Cellular immune responses against hepatitis C virus: the evidence base 2002. Clinical and Experimental Immunology, 128(2), 195-203. https://doi.org/10.1046/j.1365-2249.2002.01840.x

Vancouver

Ward S, Lauer G, Isba R, Walker B, Klenerman P. Cellular immune responses against hepatitis C virus: the evidence base 2002. Clinical and Experimental Immunology. 2002;128(2):195-203. doi: 10.1046/j.1365-2249.2002.01840.x

Author

Ward, S ; Lauer, G ; Isba, R et al. / Cellular immune responses against hepatitis C virus : the evidence base 2002. In: Clinical and Experimental Immunology. 2002 ; Vol. 128, No. 2. pp. 195-203.

Bibtex

@article{e9a7ae8004264398b7876afeeafc15b1,
title = "Cellular immune responses against hepatitis C virus: the evidence base 2002",
abstract = "Hepatitis C virus (HCV) is an RNA virus which is estimated to persistently infect about 170 million people worldwide. After acute infection, there is an initial period during which long-term outcome is decided. There is strong evidence that the cellular immune responses, involving both CD4+ and CD8+ T lymphocytes, are involved at this stage and it is their effectiveness which determines outcome. What is not understood is what determines their effectiveness. The most important component of this is likely to be some aspect of epitope selection, itself dictated by host MHC. Thus, to understand host immunity to HCV, we need to have a detailed understanding of the peptides involved in T lymphocyte responses. In this review, we discuss the peptide epitopes that have been identified so far, and their potential significance. We relate this to a scheme of host defence which may be useful for understanding natural and vaccine-induced immunity.",
keywords = "HCV CD8+ T lymphocyte CD4+ T lymphocyte HLA epitope immune escape",
author = "S Ward and G Lauer and R Isba and B Walker and P Klenerman",
year = "2002",
doi = "10.1046/j.1365-2249.2002.01840.x",
language = "English",
volume = "128",
pages = "195--203",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Cellular immune responses against hepatitis C virus

T2 - the evidence base 2002

AU - Ward, S

AU - Lauer, G

AU - Isba, R

AU - Walker, B

AU - Klenerman, P

PY - 2002

Y1 - 2002

N2 - Hepatitis C virus (HCV) is an RNA virus which is estimated to persistently infect about 170 million people worldwide. After acute infection, there is an initial period during which long-term outcome is decided. There is strong evidence that the cellular immune responses, involving both CD4+ and CD8+ T lymphocytes, are involved at this stage and it is their effectiveness which determines outcome. What is not understood is what determines their effectiveness. The most important component of this is likely to be some aspect of epitope selection, itself dictated by host MHC. Thus, to understand host immunity to HCV, we need to have a detailed understanding of the peptides involved in T lymphocyte responses. In this review, we discuss the peptide epitopes that have been identified so far, and their potential significance. We relate this to a scheme of host defence which may be useful for understanding natural and vaccine-induced immunity.

AB - Hepatitis C virus (HCV) is an RNA virus which is estimated to persistently infect about 170 million people worldwide. After acute infection, there is an initial period during which long-term outcome is decided. There is strong evidence that the cellular immune responses, involving both CD4+ and CD8+ T lymphocytes, are involved at this stage and it is their effectiveness which determines outcome. What is not understood is what determines their effectiveness. The most important component of this is likely to be some aspect of epitope selection, itself dictated by host MHC. Thus, to understand host immunity to HCV, we need to have a detailed understanding of the peptides involved in T lymphocyte responses. In this review, we discuss the peptide epitopes that have been identified so far, and their potential significance. We relate this to a scheme of host defence which may be useful for understanding natural and vaccine-induced immunity.

KW - HCV CD8+ T lymphocyte CD4+ T lymphocyte HLA epitope immune escape

U2 - 10.1046/j.1365-2249.2002.01840.x

DO - 10.1046/j.1365-2249.2002.01840.x

M3 - Journal article

C2 - 11985510

VL - 128

SP - 195

EP - 203

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 2

ER -