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Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression

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Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. / Dawson, Neil; Ferrington, Linda; Lesch, Klaus-Peter et al.
In: European Neuropsychopharmacology, Vol. 21, No. 1, 01.2011, p. 117-128.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Dawson, N, Ferrington, L, Lesch, K-P & Kelly, P 2011, 'Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression', European Neuropsychopharmacology, vol. 21, no. 1, pp. 117-128. https://doi.org/10.1016/j.euroneuro.2010.10.006

APA

Dawson, N., Ferrington, L., Lesch, K.-P., & Kelly, P. (2011). Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European Neuropsychopharmacology, 21(1), 117-128. https://doi.org/10.1016/j.euroneuro.2010.10.006

Vancouver

Dawson N, Ferrington L, Lesch KP, Kelly P. Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European Neuropsychopharmacology. 2011 Jan;21(1):117-128. doi: 10.1016/j.euroneuro.2010.10.006

Author

Dawson, Neil ; Ferrington, Linda ; Lesch, Klaus-Peter et al. / Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. In: European Neuropsychopharmacology. 2011 ; Vol. 21, No. 1. pp. 117-128.

Bibtex

@article{6c9c74fabf5541e5bf9d8f78ea895be1,
title = "Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression",
abstract = "Variation in the human serotonin transporter gene (hSERT; 5-HTT) resulting in a life-long alteration in SERT function influences anxiety and the risk of developing affective disorders. The mechanisms underlying the influence of the hSERT gene on these phenotypes remain unclear but may involve altered 5-HT receptor function. Here we characterise the cerebral metabolic response to 5-HT2A/C receptor activation in two transgenic mouse models of altered SERT function, SERT knock-out (SERT KO) and hSERT over-expressing (hSERT OE) mice, to test the hypothesis that genetically mediated variability in SERT expression alters 5-HT2A/C function. We found that a constitutive increase in SERT expression (hSERT OE) enhanced, whereas a constitutive decrease in SERT expression (SERT KO) attenuated, 5-HT2A/C function. Therefore, altered 5-HT2A/C receptor functioning in response to hSERT gene variation may contribute to its influence on affective phenotypes",
keywords = "Serotonin, Serotonin transporter, Transgenic mice , 5-HT2A/C receptor , 2-Deoxyglucose imaging , Brain function",
author = "Neil Dawson and Linda Ferrington and Klaus-Peter Lesch and Paul Kelly",
year = "2011",
month = jan,
doi = "10.1016/j.euroneuro.2010.10.006",
language = "English",
volume = "21",
pages = "117--128",
journal = "European Neuropsychopharmacology",
issn = "1873-7862",
publisher = "ELSEVIER SCIENCE BV",
number = "1",

}

RIS

TY - JOUR

T1 - Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression

AU - Dawson, Neil

AU - Ferrington, Linda

AU - Lesch, Klaus-Peter

AU - Kelly, Paul

PY - 2011/1

Y1 - 2011/1

N2 - Variation in the human serotonin transporter gene (hSERT; 5-HTT) resulting in a life-long alteration in SERT function influences anxiety and the risk of developing affective disorders. The mechanisms underlying the influence of the hSERT gene on these phenotypes remain unclear but may involve altered 5-HT receptor function. Here we characterise the cerebral metabolic response to 5-HT2A/C receptor activation in two transgenic mouse models of altered SERT function, SERT knock-out (SERT KO) and hSERT over-expressing (hSERT OE) mice, to test the hypothesis that genetically mediated variability in SERT expression alters 5-HT2A/C function. We found that a constitutive increase in SERT expression (hSERT OE) enhanced, whereas a constitutive decrease in SERT expression (SERT KO) attenuated, 5-HT2A/C function. Therefore, altered 5-HT2A/C receptor functioning in response to hSERT gene variation may contribute to its influence on affective phenotypes

AB - Variation in the human serotonin transporter gene (hSERT; 5-HTT) resulting in a life-long alteration in SERT function influences anxiety and the risk of developing affective disorders. The mechanisms underlying the influence of the hSERT gene on these phenotypes remain unclear but may involve altered 5-HT receptor function. Here we characterise the cerebral metabolic response to 5-HT2A/C receptor activation in two transgenic mouse models of altered SERT function, SERT knock-out (SERT KO) and hSERT over-expressing (hSERT OE) mice, to test the hypothesis that genetically mediated variability in SERT expression alters 5-HT2A/C function. We found that a constitutive increase in SERT expression (hSERT OE) enhanced, whereas a constitutive decrease in SERT expression (SERT KO) attenuated, 5-HT2A/C function. Therefore, altered 5-HT2A/C receptor functioning in response to hSERT gene variation may contribute to its influence on affective phenotypes

KW - Serotonin

KW - Serotonin transporter

KW - Transgenic mice

KW - 5-HT2A/C receptor

KW - 2-Deoxyglucose imaging

KW - Brain function

U2 - 10.1016/j.euroneuro.2010.10.006

DO - 10.1016/j.euroneuro.2010.10.006

M3 - Journal article

VL - 21

SP - 117

EP - 128

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 1873-7862

IS - 1

ER -