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Characterisation of structural changes in collagen with Raman spectroscopy

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Characterisation of structural changes in collagen with Raman spectroscopy. / Martinez, Marcela Garcia; Bullock, Anthony J.; MacNeil, Sheila et al.

In: APPLIED SPECTROSCOPY REVIEWS, Vol. 54, No. 6, 03.07.2019, p. 509-542.

Research output: Contribution to Journal/MagazineReview articlepeer-review

Harvard

Martinez, MG, Bullock, AJ, MacNeil, S & Rehman, IU 2019, 'Characterisation of structural changes in collagen with Raman spectroscopy', APPLIED SPECTROSCOPY REVIEWS, vol. 54, no. 6, pp. 509-542. https://doi.org/10.1080/05704928.2018.1506799

APA

Martinez, M. G., Bullock, A. J., MacNeil, S., & Rehman, I. U. (2019). Characterisation of structural changes in collagen with Raman spectroscopy. APPLIED SPECTROSCOPY REVIEWS, 54(6), 509-542. https://doi.org/10.1080/05704928.2018.1506799

Vancouver

Martinez MG, Bullock AJ, MacNeil S, Rehman IU. Characterisation of structural changes in collagen with Raman spectroscopy. APPLIED SPECTROSCOPY REVIEWS. 2019 Jul 3;54(6):509-542. Epub 2019 Jan 9. doi: 10.1080/05704928.2018.1506799

Author

Martinez, Marcela Garcia ; Bullock, Anthony J. ; MacNeil, Sheila et al. / Characterisation of structural changes in collagen with Raman spectroscopy. In: APPLIED SPECTROSCOPY REVIEWS. 2019 ; Vol. 54, No. 6. pp. 509-542.

Bibtex

@article{b8009035b091470fb39fa6befe0befcb,
title = "Characterisation of structural changes in collagen with Raman spectroscopy",
abstract = "Raman spectroscopy can detect conformational changes in collagen structures and these findings are reviewed in this article. More specifically, some progressive diseases are mainly caused by alterations of collagen molecules but what is occurring at the biochemical level of this complex molecule usually remains unclear. While it may be true that a number of analytical techniques can analyze collagen, most of them have a series of limitations that limit their applicability to a wide range of samples. To understand in more detail the progression of a disease due to changes in the collagen structure, a technique that can detect subtle alterations at the biochemical level is needed. Raman spectroscopy is a label-free and noninvasive technique that can easily pick up on any conformational changes reflected primarily at the lipids, amides and proline and hydroxyproline regions. This review is the first compilation of studies of conformational changes in collagen molecules, providing help to understand changes in collagen biochemistry that can be of relevance to the human wound healing, ageing and pathologies.",
keywords = "aldehydes, collagen, collagen crosslinking, lysyl residues, Raman spectroscopy, secondary structure",
author = "Martinez, {Marcela Garcia} and Bullock, {Anthony J.} and Sheila MacNeil and Rehman, {Ihtesham U.}",
year = "2019",
month = jul,
day = "3",
doi = "10.1080/05704928.2018.1506799",
language = "English",
volume = "54",
pages = "509--542",
journal = "APPLIED SPECTROSCOPY REVIEWS",
issn = "0570-4928",
publisher = "Taylor and Francis Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Characterisation of structural changes in collagen with Raman spectroscopy

AU - Martinez, Marcela Garcia

AU - Bullock, Anthony J.

AU - MacNeil, Sheila

AU - Rehman, Ihtesham U.

PY - 2019/7/3

Y1 - 2019/7/3

N2 - Raman spectroscopy can detect conformational changes in collagen structures and these findings are reviewed in this article. More specifically, some progressive diseases are mainly caused by alterations of collagen molecules but what is occurring at the biochemical level of this complex molecule usually remains unclear. While it may be true that a number of analytical techniques can analyze collagen, most of them have a series of limitations that limit their applicability to a wide range of samples. To understand in more detail the progression of a disease due to changes in the collagen structure, a technique that can detect subtle alterations at the biochemical level is needed. Raman spectroscopy is a label-free and noninvasive technique that can easily pick up on any conformational changes reflected primarily at the lipids, amides and proline and hydroxyproline regions. This review is the first compilation of studies of conformational changes in collagen molecules, providing help to understand changes in collagen biochemistry that can be of relevance to the human wound healing, ageing and pathologies.

AB - Raman spectroscopy can detect conformational changes in collagen structures and these findings are reviewed in this article. More specifically, some progressive diseases are mainly caused by alterations of collagen molecules but what is occurring at the biochemical level of this complex molecule usually remains unclear. While it may be true that a number of analytical techniques can analyze collagen, most of them have a series of limitations that limit their applicability to a wide range of samples. To understand in more detail the progression of a disease due to changes in the collagen structure, a technique that can detect subtle alterations at the biochemical level is needed. Raman spectroscopy is a label-free and noninvasive technique that can easily pick up on any conformational changes reflected primarily at the lipids, amides and proline and hydroxyproline regions. This review is the first compilation of studies of conformational changes in collagen molecules, providing help to understand changes in collagen biochemistry that can be of relevance to the human wound healing, ageing and pathologies.

KW - aldehydes

KW - collagen

KW - collagen crosslinking

KW - lysyl residues

KW - Raman spectroscopy

KW - secondary structure

U2 - 10.1080/05704928.2018.1506799

DO - 10.1080/05704928.2018.1506799

M3 - Review article

AN - SCOPUS:85068446571

VL - 54

SP - 509

EP - 542

JO - APPLIED SPECTROSCOPY REVIEWS

JF - APPLIED SPECTROSCOPY REVIEWS

SN - 0570-4928

IS - 6

ER -