Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation
AU - Gong, K.
AU - Rehman, I.U.
AU - Darr, J.A.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Hydroxypropylmethyl cellulose (HPMC)-indomethacin (4:1, w/w) drug composites (DCs) were prepared via supercritical carbon dioxide (sc-CO2) assisted impregnation. The effect of processing temperature (at fixed pressures) on the physical and other properties of the resulting HPMC-indomethacin DCs was investigated using a range of analytical techniques, including differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and powder X-ray diffraction (XRD) methods. The data suggest that for a 4:1 (w/w) HPMC-indomethacin ratio prepared at 130 °C (17.2 MPa), the indomethacin exists entirely in an amorphous dispersion within the polymer matrix. The primary interaction between HPMC and indomethacin appears to be hydrogen bonding between the carboxylic acid carbonyl group of indomethacin and hydroxyl group of HPMC. The initial (first 15 min) and overall drug release behavior within a 5 h timeframe for the HPMC-indomethacin DCs, was analyzed. For the HPMC-indomethacin drug composite processed at 130 °C/17.2 MPa, drug release behavior obeyed a n-power law (n = 0.54). © 2008 Elsevier B.V. All rights reserved.
AB - Hydroxypropylmethyl cellulose (HPMC)-indomethacin (4:1, w/w) drug composites (DCs) were prepared via supercritical carbon dioxide (sc-CO2) assisted impregnation. The effect of processing temperature (at fixed pressures) on the physical and other properties of the resulting HPMC-indomethacin DCs was investigated using a range of analytical techniques, including differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and powder X-ray diffraction (XRD) methods. The data suggest that for a 4:1 (w/w) HPMC-indomethacin ratio prepared at 130 °C (17.2 MPa), the indomethacin exists entirely in an amorphous dispersion within the polymer matrix. The primary interaction between HPMC and indomethacin appears to be hydrogen bonding between the carboxylic acid carbonyl group of indomethacin and hydroxyl group of HPMC. The initial (first 15 min) and overall drug release behavior within a 5 h timeframe for the HPMC-indomethacin DCs, was analyzed. For the HPMC-indomethacin drug composite processed at 130 °C/17.2 MPa, drug release behavior obeyed a n-power law (n = 0.54). © 2008 Elsevier B.V. All rights reserved.
KW - Amorphous
KW - Hydroxypropylmethyl cellulose
KW - Impregnation
KW - Indomethacin
KW - sc-CO2
KW - Supercritical fluid
KW - carbon dioxide
KW - carbonyl derivative
KW - carboxylic acid
KW - hydroxyl group
KW - hydroxypropylmethylcellulose
KW - indometacin
KW - polymer
KW - analytic method
KW - article
KW - differential scanning calorimetry
KW - drug formulation
KW - drug release
KW - hydrogen bond
KW - infrared spectroscopy
KW - priority journal
KW - Raman spectrometry
KW - X ray powder diffraction
KW - Calorimetry, Differential Scanning
KW - Carbon Dioxide
KW - Cold Temperature
KW - Delayed-Action Preparations
KW - Drug Carriers
KW - Methylcellulose
KW - Microscopy, Electron, Scanning
KW - Molecular Structure
KW - Molecular Weight
KW - Solubility
KW - Spectrophotometry, Ultraviolet
KW - Spectroscopy, Fourier Transform Infrared
KW - X-Ray Diffraction
U2 - 10.1016/j.jpba.2008.08.031
DO - 10.1016/j.jpba.2008.08.031
M3 - Journal article
VL - 48
SP - 1112
EP - 1119
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
SN - 0731-7085
IS - 4
ER -