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Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation

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Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation. / Gong, K.; Rehman, I.U.; Darr, J.A.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 48, No. 4, 01.12.2008, p. 1112-1119.

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@article{377237238c8d4c41a34f244242586e14,
title = "Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation",
abstract = "Hydroxypropylmethyl cellulose (HPMC)-indomethacin (4:1, w/w) drug composites (DCs) were prepared via supercritical carbon dioxide (sc-CO2) assisted impregnation. The effect of processing temperature (at fixed pressures) on the physical and other properties of the resulting HPMC-indomethacin DCs was investigated using a range of analytical techniques, including differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and powder X-ray diffraction (XRD) methods. The data suggest that for a 4:1 (w/w) HPMC-indomethacin ratio prepared at 130 °C (17.2 MPa), the indomethacin exists entirely in an amorphous dispersion within the polymer matrix. The primary interaction between HPMC and indomethacin appears to be hydrogen bonding between the carboxylic acid carbonyl group of indomethacin and hydroxyl group of HPMC. The initial (first 15 min) and overall drug release behavior within a 5 h timeframe for the HPMC-indomethacin DCs, was analyzed. For the HPMC-indomethacin drug composite processed at 130 °C/17.2 MPa, drug release behavior obeyed a n-power law (n = 0.54). {\textcopyright} 2008 Elsevier B.V. All rights reserved.",
keywords = "Amorphous, Hydroxypropylmethyl cellulose, Impregnation, Indomethacin, sc-CO2, Supercritical fluid, carbon dioxide, carbonyl derivative, carboxylic acid, hydroxyl group, hydroxypropylmethylcellulose, indometacin, polymer, analytic method, article, differential scanning calorimetry, drug formulation, drug release, hydrogen bond, infrared spectroscopy, priority journal, Raman spectrometry, X ray powder diffraction, Calorimetry, Differential Scanning, Carbon Dioxide, Cold Temperature, Delayed-Action Preparations, Drug Carriers, Methylcellulose, Microscopy, Electron, Scanning, Molecular Structure, Molecular Weight, Solubility, Spectrophotometry, Ultraviolet, Spectroscopy, Fourier Transform Infrared, X-Ray Diffraction",
author = "K. Gong and I.U. Rehman and J.A. Darr",
year = "2008",
month = dec,
day = "1",
doi = "10.1016/j.jpba.2008.08.031",
language = "English",
volume = "48",
pages = "1112--1119",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
issn = "0731-7085",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation

AU - Gong, K.

AU - Rehman, I.U.

AU - Darr, J.A.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Hydroxypropylmethyl cellulose (HPMC)-indomethacin (4:1, w/w) drug composites (DCs) were prepared via supercritical carbon dioxide (sc-CO2) assisted impregnation. The effect of processing temperature (at fixed pressures) on the physical and other properties of the resulting HPMC-indomethacin DCs was investigated using a range of analytical techniques, including differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and powder X-ray diffraction (XRD) methods. The data suggest that for a 4:1 (w/w) HPMC-indomethacin ratio prepared at 130 °C (17.2 MPa), the indomethacin exists entirely in an amorphous dispersion within the polymer matrix. The primary interaction between HPMC and indomethacin appears to be hydrogen bonding between the carboxylic acid carbonyl group of indomethacin and hydroxyl group of HPMC. The initial (first 15 min) and overall drug release behavior within a 5 h timeframe for the HPMC-indomethacin DCs, was analyzed. For the HPMC-indomethacin drug composite processed at 130 °C/17.2 MPa, drug release behavior obeyed a n-power law (n = 0.54). © 2008 Elsevier B.V. All rights reserved.

AB - Hydroxypropylmethyl cellulose (HPMC)-indomethacin (4:1, w/w) drug composites (DCs) were prepared via supercritical carbon dioxide (sc-CO2) assisted impregnation. The effect of processing temperature (at fixed pressures) on the physical and other properties of the resulting HPMC-indomethacin DCs was investigated using a range of analytical techniques, including differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and powder X-ray diffraction (XRD) methods. The data suggest that for a 4:1 (w/w) HPMC-indomethacin ratio prepared at 130 °C (17.2 MPa), the indomethacin exists entirely in an amorphous dispersion within the polymer matrix. The primary interaction between HPMC and indomethacin appears to be hydrogen bonding between the carboxylic acid carbonyl group of indomethacin and hydroxyl group of HPMC. The initial (first 15 min) and overall drug release behavior within a 5 h timeframe for the HPMC-indomethacin DCs, was analyzed. For the HPMC-indomethacin drug composite processed at 130 °C/17.2 MPa, drug release behavior obeyed a n-power law (n = 0.54). © 2008 Elsevier B.V. All rights reserved.

KW - Amorphous

KW - Hydroxypropylmethyl cellulose

KW - Impregnation

KW - Indomethacin

KW - sc-CO2

KW - Supercritical fluid

KW - carbon dioxide

KW - carbonyl derivative

KW - carboxylic acid

KW - hydroxyl group

KW - hydroxypropylmethylcellulose

KW - indometacin

KW - polymer

KW - analytic method

KW - article

KW - differential scanning calorimetry

KW - drug formulation

KW - drug release

KW - hydrogen bond

KW - infrared spectroscopy

KW - priority journal

KW - Raman spectrometry

KW - X ray powder diffraction

KW - Calorimetry, Differential Scanning

KW - Carbon Dioxide

KW - Cold Temperature

KW - Delayed-Action Preparations

KW - Drug Carriers

KW - Methylcellulose

KW - Microscopy, Electron, Scanning

KW - Molecular Structure

KW - Molecular Weight

KW - Solubility

KW - Spectrophotometry, Ultraviolet

KW - Spectroscopy, Fourier Transform Infrared

KW - X-Ray Diffraction

U2 - 10.1016/j.jpba.2008.08.031

DO - 10.1016/j.jpba.2008.08.031

M3 - Journal article

VL - 48

SP - 1112

EP - 1119

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

SN - 0731-7085

IS - 4

ER -