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Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone

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Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone. / Skałbania, J.; Pałasz, A.; Błaszczyk, I.; Suszka-Świtek, A.; Krzystanek, M.; Tulcanaz, K.P.; Worthington, J.J.; Mordecka-Chamera, K.

In: Pharmacological reports : PR, Vol. 73, No. 4, 31.08.2021, p. 1164-1169.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Skałbania, J, Pałasz, A, Błaszczyk, I, Suszka-Świtek, A, Krzystanek, M, Tulcanaz, KP, Worthington, JJ & Mordecka-Chamera, K 2021, 'Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone', Pharmacological reports : PR, vol. 73, no. 4, pp. 1164-1169. https://doi.org/10.1007/s43440-021-00259-7

APA

Skałbania, J., Pałasz, A., Błaszczyk, I., Suszka-Świtek, A., Krzystanek, M., Tulcanaz, K. P., Worthington, J. J., & Mordecka-Chamera, K. (2021). Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone. Pharmacological reports : PR, 73(4), 1164-1169. https://doi.org/10.1007/s43440-021-00259-7

Vancouver

Skałbania J, Pałasz A, Błaszczyk I, Suszka-Świtek A, Krzystanek M, Tulcanaz KP et al. Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone. Pharmacological reports : PR. 2021 Aug 31;73(4):1164-1169. https://doi.org/10.1007/s43440-021-00259-7

Author

Skałbania, J. ; Pałasz, A. ; Błaszczyk, I. ; Suszka-Świtek, A. ; Krzystanek, M. ; Tulcanaz, K.P. ; Worthington, J.J. ; Mordecka-Chamera, K. / Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone. In: Pharmacological reports : PR. 2021 ; Vol. 73, No. 4. pp. 1164-1169.

Bibtex

@article{8ba994ef41b54c5a8a0a703f3f2d9e30,
title = "Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone",
abstract = "Background: Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this structural study was to determine whether chronic chlorpromazine treatment affects adult neurogenesis in the canonical sites of the rat brain. At present, the clinical application of chlorpromazine is rather limited; however, it may still represent an important model in basic neuropharmacological and toxicological studies. Methods: The number of neural progenitors and immature neurons was enumerated using immunofluorescent detection of Sox2, Musashi1 and doublecortin (DCX) expression within SVZ. Results: Chlorpromazine has a depressive effect on the early phase of adult neurogenesis in the rat subventricular zone (SVZ), as the mean number of Sox-2 immunoexpressing cells decreased following treatment. Conclusion: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation. ",
keywords = "Adult neurogenesis, Chlorpromazine, Rats, Subventricular zone",
author = "J. Ska{\l}bania and A. Pa{\l}asz and I. B{\l}aszczyk and A. Suszka-{\'S}witek and M. Krzystanek and K.P. Tulcanaz and J.J. Worthington and K. Mordecka-Chamera",
year = "2021",
month = aug,
day = "31",
doi = "10.1007/s43440-021-00259-7",
language = "English",
volume = "73",
pages = "1164--1169",
journal = "Pharmacological reports : PR",
issn = "1734-1140",
publisher = "Polish Academy of Sciences Publishing House",
number = "4",

}

RIS

TY - JOUR

T1 - Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone

AU - Skałbania, J.

AU - Pałasz, A.

AU - Błaszczyk, I.

AU - Suszka-Świtek, A.

AU - Krzystanek, M.

AU - Tulcanaz, K.P.

AU - Worthington, J.J.

AU - Mordecka-Chamera, K.

PY - 2021/8/31

Y1 - 2021/8/31

N2 - Background: Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this structural study was to determine whether chronic chlorpromazine treatment affects adult neurogenesis in the canonical sites of the rat brain. At present, the clinical application of chlorpromazine is rather limited; however, it may still represent an important model in basic neuropharmacological and toxicological studies. Methods: The number of neural progenitors and immature neurons was enumerated using immunofluorescent detection of Sox2, Musashi1 and doublecortin (DCX) expression within SVZ. Results: Chlorpromazine has a depressive effect on the early phase of adult neurogenesis in the rat subventricular zone (SVZ), as the mean number of Sox-2 immunoexpressing cells decreased following treatment. Conclusion: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.

AB - Background: Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this structural study was to determine whether chronic chlorpromazine treatment affects adult neurogenesis in the canonical sites of the rat brain. At present, the clinical application of chlorpromazine is rather limited; however, it may still represent an important model in basic neuropharmacological and toxicological studies. Methods: The number of neural progenitors and immature neurons was enumerated using immunofluorescent detection of Sox2, Musashi1 and doublecortin (DCX) expression within SVZ. Results: Chlorpromazine has a depressive effect on the early phase of adult neurogenesis in the rat subventricular zone (SVZ), as the mean number of Sox-2 immunoexpressing cells decreased following treatment. Conclusion: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.

KW - Adult neurogenesis

KW - Chlorpromazine

KW - Rats

KW - Subventricular zone

U2 - 10.1007/s43440-021-00259-7

DO - 10.1007/s43440-021-00259-7

M3 - Journal article

VL - 73

SP - 1164

EP - 1169

JO - Pharmacological reports : PR

JF - Pharmacological reports : PR

SN - 1734-1140

IS - 4

ER -