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Cinchona alkaloid copolymers as fluorimetric INHIBIT and colorimetric AND logic gates for detection of iodide

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Cinchona alkaloid copolymers as fluorimetric INHIBIT and colorimetric AND logic gates for detection of iodide. / Agius, Nicola'; Ashton, Catherine J.; Willcock, Helen et al.
In: RSC Advances, Vol. 15, No. 14, 08.04.2025, p. 11121-11127.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Agius, N, Ashton, CJ, Willcock, H & Magri, DC 2025, 'Cinchona alkaloid copolymers as fluorimetric INHIBIT and colorimetric AND logic gates for detection of iodide', RSC Advances, vol. 15, no. 14, pp. 11121-11127. https://doi.org/10.1039/D5RA01281C

APA

Agius, N., Ashton, C. J., Willcock, H., & Magri, D. C. (2025). Cinchona alkaloid copolymers as fluorimetric INHIBIT and colorimetric AND logic gates for detection of iodide. RSC Advances, 15(14), 11121-11127. Advance online publication. https://doi.org/10.1039/D5RA01281C

Vancouver

Agius N, Ashton CJ, Willcock H, Magri DC. Cinchona alkaloid copolymers as fluorimetric INHIBIT and colorimetric AND logic gates for detection of iodide. RSC Advances. 2025 Apr 8;15(14):11121-11127. Epub 2025 Apr 8. doi: 10.1039/D5RA01281C

Author

Agius, Nicola' ; Ashton, Catherine J. ; Willcock, Helen et al. / Cinchona alkaloid copolymers as fluorimetric INHIBIT and colorimetric AND logic gates for detection of iodide. In: RSC Advances. 2025 ; Vol. 15, No. 14. pp. 11121-11127.

Bibtex

@article{ba2a04ebbac441fc9eb33e24560abba3,
title = "Cinchona alkaloid copolymers as fluorimetric INHIBIT and colorimetric AND logic gates for detection of iodide",
abstract = "Four cinchona alkaloid-acrylamide water soluble copolymers with a mean hydrodynamic diameter of 3 nm were synthesised by free radical polymerization. The copolymers were characterised by 1H NMR, FTIR, GPC, DLS, UV-vis and fluorescence spectroscopy. A blue emission is observed with H + switching of 185 and 175-fold for the quinidine and quinine copolymers, and 21 and 11-fold for the cinchonine and cinchonidine copolymers, while the presence of Cl -, Br - or I - causes fluorescence quenching. In emission mode, the copolymers function as fluorescent H +, X --driven INHIBIT logic gates (where X = Cl -, Br - or I -). In absorbance mode, the copolymers function as colorimetric H +, I --driven AND logic gates in 1 : 1 (v/v) THF/water with a 76-fold enhancement. The solution colour changes from colourless to yellow with formation of new absorbance bands at 288 nm and 353 nm due to a π-anion non-covalent charge transfer interaction. The copolymers may be useful as selective iodide sensors for medical and analytical diagnostics. ",
author = "Nicola' Agius and Ashton, {Catherine J.} and Helen Willcock and Magri, {David C.}",
year = "2025",
month = apr,
day = "8",
doi = "10.1039/D5RA01281C",
language = "English",
volume = "15",
pages = "11121--11127",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "14",

}

RIS

TY - JOUR

T1 - Cinchona alkaloid copolymers as fluorimetric INHIBIT and colorimetric AND logic gates for detection of iodide

AU - Agius, Nicola'

AU - Ashton, Catherine J.

AU - Willcock, Helen

AU - Magri, David C.

PY - 2025/4/8

Y1 - 2025/4/8

N2 - Four cinchona alkaloid-acrylamide water soluble copolymers with a mean hydrodynamic diameter of 3 nm were synthesised by free radical polymerization. The copolymers were characterised by 1H NMR, FTIR, GPC, DLS, UV-vis and fluorescence spectroscopy. A blue emission is observed with H + switching of 185 and 175-fold for the quinidine and quinine copolymers, and 21 and 11-fold for the cinchonine and cinchonidine copolymers, while the presence of Cl -, Br - or I - causes fluorescence quenching. In emission mode, the copolymers function as fluorescent H +, X --driven INHIBIT logic gates (where X = Cl -, Br - or I -). In absorbance mode, the copolymers function as colorimetric H +, I --driven AND logic gates in 1 : 1 (v/v) THF/water with a 76-fold enhancement. The solution colour changes from colourless to yellow with formation of new absorbance bands at 288 nm and 353 nm due to a π-anion non-covalent charge transfer interaction. The copolymers may be useful as selective iodide sensors for medical and analytical diagnostics.

AB - Four cinchona alkaloid-acrylamide water soluble copolymers with a mean hydrodynamic diameter of 3 nm were synthesised by free radical polymerization. The copolymers were characterised by 1H NMR, FTIR, GPC, DLS, UV-vis and fluorescence spectroscopy. A blue emission is observed with H + switching of 185 and 175-fold for the quinidine and quinine copolymers, and 21 and 11-fold for the cinchonine and cinchonidine copolymers, while the presence of Cl -, Br - or I - causes fluorescence quenching. In emission mode, the copolymers function as fluorescent H +, X --driven INHIBIT logic gates (where X = Cl -, Br - or I -). In absorbance mode, the copolymers function as colorimetric H +, I --driven AND logic gates in 1 : 1 (v/v) THF/water with a 76-fold enhancement. The solution colour changes from colourless to yellow with formation of new absorbance bands at 288 nm and 353 nm due to a π-anion non-covalent charge transfer interaction. The copolymers may be useful as selective iodide sensors for medical and analytical diagnostics.

U2 - 10.1039/D5RA01281C

DO - 10.1039/D5RA01281C

M3 - Journal article

C2 - 40201211

VL - 15

SP - 11121

EP - 11127

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 14

ER -