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CO2 signaling mediates neurovascular coupling in the cerebral cortex

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CO2 signaling mediates neurovascular coupling in the cerebral cortex. / Hosford, Patrick; Wells, Jack; Nizari, S et al.
In: Nature Communications, Vol. 13, 2125, 19.04.2022.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hosford, P, Wells, J, Nizari, S, Christie, IN, Theparambil, SM, Castro, PA, Hadjihambi, A, Barros, LF, Ruminot, I, Lythgoe, MF & Gourine, A 2022, 'CO2 signaling mediates neurovascular coupling in the cerebral cortex', Nature Communications, vol. 13, 2125. https://doi.org/10.1038/s41467-022-29622-9

APA

Hosford, P., Wells, J., Nizari, S., Christie, IN., Theparambil, SM., Castro, PA., Hadjihambi, A., Barros, LF., Ruminot, I., Lythgoe, MF., & Gourine, A. (2022). CO2 signaling mediates neurovascular coupling in the cerebral cortex. Nature Communications, 13, Article 2125. https://doi.org/10.1038/s41467-022-29622-9

Vancouver

Hosford P, Wells J, Nizari S, Christie IN, Theparambil SM, Castro PA et al. CO2 signaling mediates neurovascular coupling in the cerebral cortex. Nature Communications. 2022 Apr 19;13:2125. doi: 10.1038/s41467-022-29622-9

Author

Hosford, Patrick ; Wells, Jack ; Nizari, S et al. / CO2 signaling mediates neurovascular coupling in the cerebral cortex. In: Nature Communications. 2022 ; Vol. 13.

Bibtex

@article{c43d41dca253421980f4497e5931ac9f,
title = "CO2 signaling mediates neurovascular coupling in the cerebral cortex",
abstract = "Neurovascular coupling is a fundamental brain mechanism that regulates local cerebral blood flow (CBF) in response to changes in neuronal activity. Functional imaging techniques are commonly used to record these changes in CBF as a proxy of neuronal activity to study the human brain. However, the mechanisms of neurovascular coupling remain incompletely understood. Here we show in experimental animal models (laboratory rats and mice) that the neuronal activity-dependent increases in local CBF in the somatosensory cortex are prevented by saturation of the CO2-sensitive vasodilatory brain mechanism with surplus of exogenous CO2 or disruption of brain CO2/HCO3- transport by genetic knockdown of electrogenic sodium-bicarbonate cotransporter 1 (NBCe1) expression in astrocytes. A systematic review of the literature data shows that CO2 and increased neuronal activity recruit the same vasodilatory signaling pathways. These results and analysis suggest that CO2 mediates signaling between neurons and the cerebral vasculature to regulate brain blood flow in accord with changes in the neuronal activity.",
author = "Patrick Hosford and Jack Wells and S Nizari and IN Christie and SM Theparambil and PA Castro and Anna Hadjihambi and LF Barros and Iv{\'a}n Ruminot and MF Lythgoe and Alexander Gourine",
year = "2022",
month = apr,
day = "19",
doi = "10.1038/s41467-022-29622-9",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - CO2 signaling mediates neurovascular coupling in the cerebral cortex

AU - Hosford, Patrick

AU - Wells, Jack

AU - Nizari, S

AU - Christie, IN

AU - Theparambil, SM

AU - Castro, PA

AU - Hadjihambi, Anna

AU - Barros, LF

AU - Ruminot, Iván

AU - Lythgoe, MF

AU - Gourine, Alexander

PY - 2022/4/19

Y1 - 2022/4/19

N2 - Neurovascular coupling is a fundamental brain mechanism that regulates local cerebral blood flow (CBF) in response to changes in neuronal activity. Functional imaging techniques are commonly used to record these changes in CBF as a proxy of neuronal activity to study the human brain. However, the mechanisms of neurovascular coupling remain incompletely understood. Here we show in experimental animal models (laboratory rats and mice) that the neuronal activity-dependent increases in local CBF in the somatosensory cortex are prevented by saturation of the CO2-sensitive vasodilatory brain mechanism with surplus of exogenous CO2 or disruption of brain CO2/HCO3- transport by genetic knockdown of electrogenic sodium-bicarbonate cotransporter 1 (NBCe1) expression in astrocytes. A systematic review of the literature data shows that CO2 and increased neuronal activity recruit the same vasodilatory signaling pathways. These results and analysis suggest that CO2 mediates signaling between neurons and the cerebral vasculature to regulate brain blood flow in accord with changes in the neuronal activity.

AB - Neurovascular coupling is a fundamental brain mechanism that regulates local cerebral blood flow (CBF) in response to changes in neuronal activity. Functional imaging techniques are commonly used to record these changes in CBF as a proxy of neuronal activity to study the human brain. However, the mechanisms of neurovascular coupling remain incompletely understood. Here we show in experimental animal models (laboratory rats and mice) that the neuronal activity-dependent increases in local CBF in the somatosensory cortex are prevented by saturation of the CO2-sensitive vasodilatory brain mechanism with surplus of exogenous CO2 or disruption of brain CO2/HCO3- transport by genetic knockdown of electrogenic sodium-bicarbonate cotransporter 1 (NBCe1) expression in astrocytes. A systematic review of the literature data shows that CO2 and increased neuronal activity recruit the same vasodilatory signaling pathways. These results and analysis suggest that CO2 mediates signaling between neurons and the cerebral vasculature to regulate brain blood flow in accord with changes in the neuronal activity.

UR - https://europepmc.org/articles/PMC9019094

U2 - 10.1038/s41467-022-29622-9

DO - 10.1038/s41467-022-29622-9

M3 - Journal article

C2 - 35440557

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2125

ER -