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Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy

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  • Gargi Banerjee
  • Duncan Wilson
  • Gareth Ambler
  • Karen Osei Bonsu Appiah
  • Clare Shakeshaft
  • Surabhika Lunawat
  • Hannah Cohen
  • Tarek Yousry
  • Med Habil
  • Gregory Y.H. Lip
  • Keith W. Muir
  • Martin M. Brown
  • Rustam Al Shahi Salman
  • Hans Rolf Jäger
  • David J. Werring
  • Louise Shaw
  • Jane Sword
  • Azlisham Mohd Nor
  • Pankaj Sharma
  • Roland Veltkamp
  • Deborah Kelly
  • Frances Harrington
  • Marc Randall
  • Matthew Smith
  • Karim Mahawish
  • Abduelbaset Elmarim
  • Bernard Esisi
  • Claire Cullen
  • Arumug Nallasivam
  • Christopher Price
  • Adrian Barry
  • Christine Roffe
  • John Coyle
  • Ahamad Hassan
  • Caroline Lovelock
  • Jonathan Birns
  • David Cohen
  • L. Sekaran
  • Adrian Parry-Jones
  • Anthea Parry
  • David Hargroves
  • Harald Proschel
  • Prabel Datta
  • Khaled Darawil
  • Aravindakshan Manoj
  • Mathew Burn
  • Chris Patterson
  • Elio Giallombardo
  • Nigel Smyth
<mark>Journal publication date</mark>1/01/2018
Issue number1
Number of pages6
Pages (from-to)40-45
Publication StatusPublished
Early online date15/12/17
<mark>Original language</mark>English


Background and Purpose-Although the association between cerebral amyloid angiopathy (CAA) and cognitive impairment is increasingly recognized, it is not clear whether this is because of the impact of recurrent intracerebral hemorrhage (ICH) events, disruptions caused by cerebral small vessel damage, or both. We investigated this by considering whether cognitive impairment before ICH was associated with neuroimaging features of CAA on magnetic resonance imaging. Methods-We studied 166 patients with neuroimaging-confrmed ICH recruited to a prospective multicentre observational study. Preexisting cognitive impairment was determined using the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Magnetic resonance imaging markers of cerebral small vessel disease, including CAA, were rated by trained observers according to consensus guidelines. Results-The prevalence of cognitive impairment before ICH was 24.7% (n=41) and, in adjusted analyses, was associated with fulflling the modifed Boston criteria for probable CAA at presentation (odds ratio, 4.01; 95% confdence interval, 1.53-10.51; P=0.005) and a higher composite CAA score (for each point increase, odds ratio, 1.42; 95% confdence interval, 1.03-1.97; P=0.033). We also found independent associations between pre-ICH cognitive decline and the presence of cortical superfcial siderosis, strictly lobar microbleeds, and lobar ICH location, but not with other neuroimaging markers, or a composite small vessel disease score. Conclusions-CAA (defned using magnetic resonance imaging markers) is associated with cognitive decline before symptomatic ICH. This provides evidence that small vessel disruption in CAA makes an independent contribution to cognitive impairment, in addition to effects due to brain injury caused directly by ICH.