Home > Research > Publications & Outputs > Cold Atmospheric Plasma-Activated Composite Hyd...

Research

Links

Text available via DOI:

Keywords

View graph of relations

Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials. / Gaur, Nishtha; Patenall, Bethany L.; Ghimire, Bhagirath et al.
In: ACS Applied Materials & Interfaces, Vol. 15, No. 16, 26.04.2023, p. 19989-19996.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gaur, N, Patenall, BL, Ghimire, B, Thet, NT, Gardiner, JE, Doare, KEL, Ramage, G, Short, B, Heylen, RA, Williams, C, Short, RD & Jenkins, TA 2023, 'Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials', ACS Applied Materials & Interfaces, vol. 15, no. 16, pp. 19989-19996. https://doi.org/10.1021/acsami.3c01208

APA

Gaur, N., Patenall, B. L., Ghimire, B., Thet, N. T., Gardiner, J. E., Doare, K. E. L., Ramage, G., Short, B., Heylen, R. A., Williams, C., Short, R. D., & Jenkins, T. A. (2023). Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials. ACS Applied Materials & Interfaces, 15(16), 19989-19996. https://doi.org/10.1021/acsami.3c01208

Vancouver

Gaur N, Patenall BL, Ghimire B, Thet NT, Gardiner JE, Doare KEL et al. Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials. ACS Applied Materials & Interfaces. 2023 Apr 26;15(16):19989-19996. Epub 2023 Apr 11. doi: 10.1021/acsami.3c01208

Author

Gaur, Nishtha ; Patenall, Bethany L. ; Ghimire, Bhagirath et al. / Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials. In: ACS Applied Materials & Interfaces. 2023 ; Vol. 15, No. 16. pp. 19989-19996.

Bibtex

@article{23cc63a91ad0446d988a54576ff3d39a,
title = "Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials",
abstract = "We present the concept of a versatile drug-loaded composite hydrogel that can be activated using an argon-based cold atmospheric plasma (CAP) jet to deliver both a drug and CAP-generated molecules, concomitantly, in a tissue target. To demonstrate this concept, we utilized the antibiotic gentamicin that is encapsulated in sodium polyacrylate (PAA) particles, which are dispersed within a poly(vinyl alcohol) (PVA) hydrogel matrix. The final product is a gentamicin-PAA-PVA composite hydrogel suitable for an on-demand triggered release using CAP. We show that by activating using CAP, we can effectively release gentamicin from the hydrogel and also eradicate the bacteria effectively, both in the planktonic state and within a biofilm. Besides gentamicin, we also successfully demonstrate the applicability of the CAP-activated composite hydrogel loaded with other antimicrobial agents such as cetrimide and silver. This concept of a composite hydrogel is potentially adaptable to a range of therapeutics (such as antimicrobials, anticancer agents, and nanoparticles) and activatable using any dielectric barrier discharge CAP device.",
keywords = "cold atmospheric plasma, plasma jet, composite hydrogels, drug delivery, reactive oxygen and nitrogen species, antimicrobial, biofilms, gentamicin",
author = "Nishtha Gaur and Patenall, {Bethany L.} and Bhagirath Ghimire and Thet, {Naing T.} and Gardiner, {Jordan E.} and Doare, {Krystal E. Le} and Gordon Ramage and Bryn Short and Heylen, {Rachel A.} and Craig Williams and Short, {Robert D.} and Jenkins, {Toby A.}",
year = "2023",
month = apr,
day = "26",
doi = "10.1021/acsami.3c01208",
language = "English",
volume = "15",
pages = "19989--19996",
journal = "ACS Applied Materials & Interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "16",

}

RIS

TY - JOUR

T1 - Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials

AU - Gaur, Nishtha

AU - Patenall, Bethany L.

AU - Ghimire, Bhagirath

AU - Thet, Naing T.

AU - Gardiner, Jordan E.

AU - Doare, Krystal E. Le

AU - Ramage, Gordon

AU - Short, Bryn

AU - Heylen, Rachel A.

AU - Williams, Craig

AU - Short, Robert D.

AU - Jenkins, Toby A.

PY - 2023/4/26

Y1 - 2023/4/26

N2 - We present the concept of a versatile drug-loaded composite hydrogel that can be activated using an argon-based cold atmospheric plasma (CAP) jet to deliver both a drug and CAP-generated molecules, concomitantly, in a tissue target. To demonstrate this concept, we utilized the antibiotic gentamicin that is encapsulated in sodium polyacrylate (PAA) particles, which are dispersed within a poly(vinyl alcohol) (PVA) hydrogel matrix. The final product is a gentamicin-PAA-PVA composite hydrogel suitable for an on-demand triggered release using CAP. We show that by activating using CAP, we can effectively release gentamicin from the hydrogel and also eradicate the bacteria effectively, both in the planktonic state and within a biofilm. Besides gentamicin, we also successfully demonstrate the applicability of the CAP-activated composite hydrogel loaded with other antimicrobial agents such as cetrimide and silver. This concept of a composite hydrogel is potentially adaptable to a range of therapeutics (such as antimicrobials, anticancer agents, and nanoparticles) and activatable using any dielectric barrier discharge CAP device.

AB - We present the concept of a versatile drug-loaded composite hydrogel that can be activated using an argon-based cold atmospheric plasma (CAP) jet to deliver both a drug and CAP-generated molecules, concomitantly, in a tissue target. To demonstrate this concept, we utilized the antibiotic gentamicin that is encapsulated in sodium polyacrylate (PAA) particles, which are dispersed within a poly(vinyl alcohol) (PVA) hydrogel matrix. The final product is a gentamicin-PAA-PVA composite hydrogel suitable for an on-demand triggered release using CAP. We show that by activating using CAP, we can effectively release gentamicin from the hydrogel and also eradicate the bacteria effectively, both in the planktonic state and within a biofilm. Besides gentamicin, we also successfully demonstrate the applicability of the CAP-activated composite hydrogel loaded with other antimicrobial agents such as cetrimide and silver. This concept of a composite hydrogel is potentially adaptable to a range of therapeutics (such as antimicrobials, anticancer agents, and nanoparticles) and activatable using any dielectric barrier discharge CAP device.

KW - cold atmospheric plasma

KW - plasma jet

KW - composite hydrogels

KW - drug delivery

KW - reactive oxygen and nitrogen species

KW - antimicrobial

KW - biofilms

KW - gentamicin

U2 - 10.1021/acsami.3c01208

DO - 10.1021/acsami.3c01208

M3 - Journal article

C2 - 37040527

VL - 15

SP - 19989

EP - 19996

JO - ACS Applied Materials & Interfaces

JF - ACS Applied Materials & Interfaces

SN - 1944-8244

IS - 16

ER -