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Collagen-based scaffold as a delivery system for a niacinamide dominated formulation without loss of resistance against enzymatic degradation

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Collagen-based scaffold as a delivery system for a niacinamide dominated formulation without loss of resistance against enzymatic degradation. / Wessels, Quenton Bester.

In: International Journal of Biomedical Engineering and Technology, Vol. 20, No. 4, 2016, p. 330-343.

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Wessels, Quenton Bester. / Collagen-based scaffold as a delivery system for a niacinamide dominated formulation without loss of resistance against enzymatic degradation. In: International Journal of Biomedical Engineering and Technology. 2016 ; Vol. 20, No. 4. pp. 330-343.

Bibtex

@article{d6dcfd95a8ca4085be24e265ae04af3b,
title = "Collagen-based scaffold as a delivery system for a niacinamide dominated formulation without loss of resistance against enzymatic degradation",
abstract = "Exogenous factors aimed at promoting fibroblast activity might hold the key to improving the clinical outcome of chronic wounds. The current study explores the feasibility to use a collagen-based scaffold as a delivery system for a niacinamide dominated formulation in vivo. The combined use of niacinamide, L-carnosine, hesperidin and a HSP70 homologue is known to promote fibroblast activity in vitro. Scaffold mediated wound healing was assessed in 16 female Sprague-Dawley rats that received both a control scaffold and an enhanced scaffold. The test scaffolds presented with a higher fibroblast count (60.49 ± 9.90% of the total cell infiltrate) on day 7 compared that of the control scaffolds (42.62 ± 13.60%) but was found to be statistically insignificant. However, the addition of these active components did not compromise the in vivo resistance against enzymatic degradation nor alter the scaffold microenvironment deleteriously.",
keywords = "collagen scaffold, niacinamide, L-carnosine, hesperidin, HSP70 homologue, enzymatic degradation, delivery systems, fibroblast activity, chronic wounds, wound healing",
author = "Wessels, {Quenton Bester}",
year = "2016",
doi = "10.1504/IJBET.2016.076607",
language = "English",
volume = "20",
pages = "330--343",
journal = "International Journal of Biomedical Engineering and Technology",
issn = "1752-6418",
publisher = "Inderscience Enterprises Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Collagen-based scaffold as a delivery system for a niacinamide dominated formulation without loss of resistance against enzymatic degradation

AU - Wessels, Quenton Bester

PY - 2016

Y1 - 2016

N2 - Exogenous factors aimed at promoting fibroblast activity might hold the key to improving the clinical outcome of chronic wounds. The current study explores the feasibility to use a collagen-based scaffold as a delivery system for a niacinamide dominated formulation in vivo. The combined use of niacinamide, L-carnosine, hesperidin and a HSP70 homologue is known to promote fibroblast activity in vitro. Scaffold mediated wound healing was assessed in 16 female Sprague-Dawley rats that received both a control scaffold and an enhanced scaffold. The test scaffolds presented with a higher fibroblast count (60.49 ± 9.90% of the total cell infiltrate) on day 7 compared that of the control scaffolds (42.62 ± 13.60%) but was found to be statistically insignificant. However, the addition of these active components did not compromise the in vivo resistance against enzymatic degradation nor alter the scaffold microenvironment deleteriously.

AB - Exogenous factors aimed at promoting fibroblast activity might hold the key to improving the clinical outcome of chronic wounds. The current study explores the feasibility to use a collagen-based scaffold as a delivery system for a niacinamide dominated formulation in vivo. The combined use of niacinamide, L-carnosine, hesperidin and a HSP70 homologue is known to promote fibroblast activity in vitro. Scaffold mediated wound healing was assessed in 16 female Sprague-Dawley rats that received both a control scaffold and an enhanced scaffold. The test scaffolds presented with a higher fibroblast count (60.49 ± 9.90% of the total cell infiltrate) on day 7 compared that of the control scaffolds (42.62 ± 13.60%) but was found to be statistically insignificant. However, the addition of these active components did not compromise the in vivo resistance against enzymatic degradation nor alter the scaffold microenvironment deleteriously.

KW - collagen scaffold

KW - niacinamide

KW - L-carnosine

KW - hesperidin

KW - HSP70 homologue

KW - enzymatic degradation

KW - delivery systems

KW - fibroblast activity

KW - chronic wounds

KW - wound healing

U2 - 10.1504/IJBET.2016.076607

DO - 10.1504/IJBET.2016.076607

M3 - Journal article

VL - 20

SP - 330

EP - 343

JO - International Journal of Biomedical Engineering and Technology

JF - International Journal of Biomedical Engineering and Technology

SN - 1752-6418

IS - 4

ER -