The sixth edition of the International Conference on “Advancements in Nuclear Instrumentation Measurement Methods and their Applications” (ANIMMA) was held in Portorož, Slovenia, from June 17–21, 2019. The conference attracted almost 300 participants from 32 different countries, coming from academy, research institutes, and industry to discuss new scientific and technical prospects in all fields where nuclear instrumentation and measurements techniques play a major role. The scientific program included 25 invited talks, 125 oral presentations, and 77 poster presentations on the following topics: fundamental physics; fusion diagnostics and technology; nuclear power reactors monitoring and control; research reactors; nuclear fuel cycle; decommissioning, dismantling, and remote handling; safeguards and homeland security; severe accident monitoring; environmental and medical sciences; and education, training, and outreach.