Final published version
Licence: CC BY-NC
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Comparative life cycle assessment of NAD(P)H regeneration technologies
AU - Burnett, Joseph
AU - Sun, Ziying
AU - Li, Jianwei
AU - Wang, Xiaonan
AU - Wang, Xiaodong
PY - 2021/9/21
Y1 - 2021/9/21
N2 - NAD(P)H is a key cofactor widely used in biocatalytic reductive transformations, facilitating a wide range of industrially significant reactions which ultimately result in the consumption of the costly cofactor. To make NAD(P)H dependent biotransformations sustainable and economically feasible, different catalytic routes have been investigated to regenerate NAD(P)H. Here we report a comprehensive life cycle assessment (LCA) of these catalytic regeneration methods. Midpoint characterisation and normalisation show that the synthesis of the catalyst, specifically the use of noble metals and energy consumption, dominate the environmental impacts and have the greatest contribution to all considered impact categories. This comparative LCA highlights the need for future investigation into noble metal based catalyst alternatives, to provide cleaner and more sustainable methods of regenerating the cofactor NAD(P)H.
AB - NAD(P)H is a key cofactor widely used in biocatalytic reductive transformations, facilitating a wide range of industrially significant reactions which ultimately result in the consumption of the costly cofactor. To make NAD(P)H dependent biotransformations sustainable and economically feasible, different catalytic routes have been investigated to regenerate NAD(P)H. Here we report a comprehensive life cycle assessment (LCA) of these catalytic regeneration methods. Midpoint characterisation and normalisation show that the synthesis of the catalyst, specifically the use of noble metals and energy consumption, dominate the environmental impacts and have the greatest contribution to all considered impact categories. This comparative LCA highlights the need for future investigation into noble metal based catalyst alternatives, to provide cleaner and more sustainable methods of regenerating the cofactor NAD(P)H.
U2 - 10.1039/D1GC02349G
DO - 10.1039/D1GC02349G
M3 - Journal article
VL - 23
SP - 7162
EP - 7169
JO - Green Chemistry
JF - Green Chemistry
SN - 1463-9262
IS - 18
ER -