Final published version
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed) › peer-review
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed) › peer-review
}
TY - CHAP
T1 - Comparative Proteogenomic Approaches for Mapping the Global Proteome of the Unsequenced Leishmania Vector Phlebotomus papatasi
AU - Patole, M.S.
AU - Sharma, J.
AU - Pawar, H.
PY - 2024/10/23
Y1 - 2024/10/23
N2 - The rapid improvements in next-generation sequencing technologies have made it possible to quickly access in-depth genome sequence data. This has resulted in a flurry of genome sequences of various organisms being published and made publicly available in the last two decades. However, not all organisms have genome sequence data available. Various factors play a role, such as the importance of the organism, either medically or economically, and the genome complexity of the organisms. Phlebotomus papatasi is the sandfly vector for the Leishmania parasite, which is the causative agent for leishmaniasis. P. papatasi is a hematophagous vector, and the female flies feed on human blood to complete their reproductive cycle. The P. papatasi genome is currently being sequenced as part of a multicentric consortium, and the genome sequence is not published to date. Hence, efforts to map its global proteome are hindered in P. papatasi. In such cases, comparative proteogenomic approaches can help map the global proteome of an unsequenced organism using homology-based methods.
AB - The rapid improvements in next-generation sequencing technologies have made it possible to quickly access in-depth genome sequence data. This has resulted in a flurry of genome sequences of various organisms being published and made publicly available in the last two decades. However, not all organisms have genome sequence data available. Various factors play a role, such as the importance of the organism, either medically or economically, and the genome complexity of the organisms. Phlebotomus papatasi is the sandfly vector for the Leishmania parasite, which is the causative agent for leishmaniasis. P. papatasi is a hematophagous vector, and the female flies feed on human blood to complete their reproductive cycle. The P. papatasi genome is currently being sequenced as part of a multicentric consortium, and the genome sequence is not published to date. Hence, efforts to map its global proteome are hindered in P. papatasi. In such cases, comparative proteogenomic approaches can help map the global proteome of an unsequenced organism using homology-based methods.
U2 - 10.1007/978-1-0716-4152-1_15
DO - 10.1007/978-1-0716-4152-1_15
M3 - Chapter (peer-reviewed)
SN - 9781071641514
T3 - Methods in Molecular Biology
SP - 265
EP - 277
BT - Protogenomics
A2 - Allmer, Jens
A2 - Kumar, Abhishek
PB - Humana Press
CY - New York
ER -